2018
DOI: 10.1016/j.jamcollsurg.2018.09.003
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Abstract: Background: Endotheliopathy of trauma is characterized by breakdown of the endothelial glycocalyx. Elevated biomarkers of endotheliopathy, such as serum syndecan-1 (Synd-1) ≥ 40 ng/mL, have been associated with increased need for transfusions, complications, and mortality. We hypothesized that severely injured trauma patients who exhibit elevated Synd-1 levels shortly after admission have an increased likelihood of developing sepsis. Study Design: We analyzed a subset of PROPPR patients that survived at leas… Show more

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Cited by 44 publications
(41 citation statements)
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“…Endothelial function HDIVC decreases circulating thrombomodulin, an endothelial membrane protein receptor for thrombin that converts thrombin to an anticoagulant capable of activating protein C [95]. Decreases plasma Syndecan-1 levels, a by-product of endothelial glycocalyx shedding [96][97][98][99][100][101][102][103][104][105][106][107][108].…”
Section: Inflammatory Mediatorsmentioning
confidence: 99%
“…Endothelial function HDIVC decreases circulating thrombomodulin, an endothelial membrane protein receptor for thrombin that converts thrombin to an anticoagulant capable of activating protein C [95]. Decreases plasma Syndecan-1 levels, a by-product of endothelial glycocalyx shedding [96][97][98][99][100][101][102][103][104][105][106][107][108].…”
Section: Inflammatory Mediatorsmentioning
confidence: 99%
“…In addition to aging and chronic disease, there are other factors such as critical illness, surgery, trauma or hypervolemia which induce ED preceding sepsis [ 77 , 78 , 79 ]. Increasing evidence supports that this previous ED could facilitate the incidence of sepsis.…”
Section: Other Factors Inducing Ed Before Sepsismentioning
confidence: 99%
“…In the same scenario (non-septic critically-ill patients), Vassiliou A.G. et al have also demonstrated that soluble endothelial protein C receptor levels at intensive care unit (ICU) admission (a protein regulates the protein C anticoagulant activity) are elevated in the subjects who will subsequently become septic [ 81 ]. In a recently published article, Wei S. et al demonstrate that a high degree of ED following traumatism (as assessed by levels of Syndecan 1 in serum) is associated with an increased risk of developing sepsis [ 79 ]. An old work from Ikegami K. et al showed that the degree of endothelial cell injury in patients suffering blunt trauma (as quantified by the soluble thrombomodulin levels) predicted the incidence of sepsis [ 82 ].…”
Section: Other Factors Inducing Ed Before Sepsismentioning
confidence: 99%
“…The dynamic patterns of immune mediator levels have been correlated with injury characteristics (10), patient demographics (19,20), and outcomes (16,21). Likewise, endothelial proteins such as syndecan-1 and thrombomodulin (TM) have been used to assess the degree of endothelial glycocalyx damage and to predict mortality following trauma (22)(23)(24). The immune system and endothelium operate in concert in the host response to injury; therefore, an impairment in one of these systems would be expected to manifest as detectable alterations in the other.…”
Section: Introductionmentioning
confidence: 99%