Challenges in managing graft-versus-host disease in developing countries: a perspective

Saleem, Muhammad; Aljurf, Mahmoud; Srivastava, Alok; Shamsi, Tahir; Lu, Pei-Hua; Hamidieh, Amir Ali; Haddad, Alaa El; Hashmi, Shahrukh K.

doi:10.1038/s41409-018-0333-z

Cited by 7 publications

(3 citation statements)

References 36 publications

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“…At our centers, we started to use novel drugs for the management of cGVHD, including bortezomib, ruxolitinib, and ibrutinib. 28 However, many other drugs with reported efficacy in this setting are not readily available in Egypt, and the main challenge to the use of such novel approaches is the price, which is usually beyond the capability of many patients. Additionally, it is not yet covered by thirdparty payers.…”

Section: G Challenges Facing Gvhd Management In Egyptmentioning

confidence: 99%

Hematopoietic Stem Cell Transplantation in Egypt Challenges and Solutions

Mahmoud

Fathy²,

Elhaddad

et al. 2020

Mediterr J Hematol Infect Dis

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Hematopoietic stem cell transplantation (HSCT) is now an established treatment modality with definitive indications for many hematological disorders. However, this line of treatment requires tremendous resources, and it becomes increasingly difficult for transplanters practicing in the developing world to reconcile the difference between what is possible and what is available. On the basis of 30 years of experience and more than 4250 transplants , this article will focus on the challenges faced our HSCT program and how they were solved. The HSCT program in Egypt started in 1989 on a narrow scale and since that time we faced many challenges.In 1997, the transplant rate increased dramatically with the opening of many HSCT units distributed allover Egypt. Our team is registered in the Center for International Blood and Marrow Transplant Research ,and the number of transplants performed till December 2019 exceeded 4000 cases (60% allogeneic and 40% autologous).

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Section: G Challenges Facing Gvhd Management In Egyptmentioning

confidence: 99%

Hematopoietic Stem Cell Transplantation in Egypt Challenges and Solutions

Mahmoud

Fathy²,

Elhaddad

et al. 2020

Mediterr J Hematol Infect Dis

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“…In developing countries, the problem of GVHD is further compounded by logistic, political, social issues, and limited resources for its treatment. Also access to treatment modalities like extra-corporeal photophoresis (ECP) is very limited [20]. Hence, the treatment can be extremely challenging.…”

Section: Indian Scenariomentioning

confidence: 99%

“…Most of our patients do not have access or the resources for optimal management of cGVHD. Therefore, we need to set up a system for long-term follow-up of HSCT survivors and also have a structured approach to ensure early diagnosis and treatment for cGVHD following the NIH model [20]. To make this possible, we must generate awareness and also indicate health policy programs to achieve access and treatment for all patients with GVHD adopting a multi-speciality approach with setting up of multi-disciplinary clinics.…”

Section: Indian Scenariomentioning

confidence: 99%

Summary of the Highlights of 2019 ASTCT Meeting by iNDUS BMT Group at Chennai, India

Sharma

George

Subhash

et al. 2019

Indian J Hematol Blood Transfus

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This article summarises the main highlights of the abstracts presented at the annual meeting of American Society of Transplantation and Cellular Therapy (ASTCT). The highlights of ASTCT meeting were organised by iNDUS BMT group in Chennai, India. The purpose of the highlight meeting was to educate the students about the latest research in the field of hematopoietic stem cell transplantation and its applicability for the developing country perspective.

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Feasibility and Experiences of HCT in Resource-Constrained Settings

Srivastava,

Duarte,

Faulkner

2024

The EBMT Handbook

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Even though hematopoietic cell transplant (HCT) has been in vogue for more than six decades as a curative therapy for many hematological disorders, with increasing trends in all parts of the world (Fig. 69.1), the density of HCT services is low and access to existing services remain an unmet need in the resource-constrained settings (RCSs) of low- and middle-income countries (LMICs) (Niederwieser et al. 2022). The silver lining though is that within these limitations, there are several examples of high-quality HCT services functioning in several countries, some with full national/international accreditation showing that even in those circumstances this is possible (Damodar et al. 2021). The goal of this chapter will be to discuss how good HCT services may be established and sustained in RCSs (Pasquini et al. 2019; Faulkner et al. 2021).

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Challenges in managing graft-versus-host disease in developing countries: a perspective

Cited by 7 publications

References 36 publications

Hematopoietic Stem Cell Transplantation in Egypt Challenges and Solutions

Hematopoietic Stem Cell Transplantation in Egypt Challenges and Solutions

Summary of the Highlights of 2019 ASTCT Meeting by iNDUS BMT Group at Chennai, India

Feasibility and Experiences of HCT in Resource-Constrained Settings

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