Multi‐omics analysis points to altered platelet functions in severe food‐associated respiratory allergy

Obeso, David; Mera-Berriatua, Leticia; Rodríguez-Coira, Juan; Rosace, Domenico; Fernández, Paloma; Martín-Antoniano, Isabel Adoración; Santaolalla, M; Martín, G.; Chivato, T.; Fernández‐Rivas, Montserrat; Ramos, Tania; Blanco, Carlos; Alvarado, María; Domı́nguez, Carmen; Angulo, Santiago; Barbas, Coral; Barber, Domingo; Villaseñor, Alma; Escribese, María M.

doi:10.1111/all.13563

Cited by 67 publications

(112 citation statements)

References 67 publications

Supporting

Mentioning

102

Contrasting

Unclassified

Order By: Relevance

“…38 Changes in plasma sphingolipids have been reported in association with severe allergic respiratory responses. 39 In a recent report higher levels of stool sphingolipids were detected in foodsensitized children compared with patients with clinical FA or control subjects. 15 iNKT cells recognize lipid ligands presented by the atypical MHC class I molecule CD1d, including Bacteroides species-derived sphingolipids.…”

Section: Discussionmentioning

confidence: 94%

Untargeted metabolomic profiling identifies disease-specific signatures in food allergy and asthma

Crestani

Harb

Charbonnier

et al. 2020

Journal of Allergy and Clinical Immunology

101

128

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 94%

Untargeted metabolomic profiling identifies disease-specific signatures in food allergy and asthma

Crestani

Harb

Charbonnier

et al. 2020

Journal of Allergy and Clinical Immunology

101

128

View full text Add to dashboard Cite

show abstract

“…This allows longitudinal immunoprofiling of relevant cell subsets in individuals before and during AIT. Better dissection of mechanisms underlying allergic diseases informs better tailoring of therapies Unmet needs in precision medicine Consensus on endotypes and clinically applicable biomarkers for distinct allergic disorders Accurate targeted activity; even, widespread or specific as needed Increased availability of oral formulations: solid or liquid More favorable dosing intervals Minimization of adverse side effects (especially anaphylactic/allergic reactions, antibody induction, complement activation) Economic feasibility enhancement Determination of long‐term effects “Large dataset” protection and interpretation, including ethical considerations Development of a precision medicine‐specific nomenclature Development of treatment and diagnostic algorithms Development of precision medicine–focused guidelines …”

Section: Diagnostic Challenges and Regulatory Considerationsmentioning

confidence: 99%

“…Better dissection of mechanisms underlying allergic diseases informs better tailoring of therapies. 115,116,[119][120][121][122]124,125…”

Section: Precision Medicine and Immune Monitoring Of Allergic Diseasesmentioning

confidence: 99%

Future research trends in understanding the mechanisms underlying allergic diseases for improved patient care

Breiteneder

Diamant

Eiwegger

et al. 2019

Allergy

View full text Add to dashboard Cite

This is an open access article under the terms of the Creat ive Commo ns Attri bution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. AbstractThe specialties of allergy and clinical immunology have entered the era of precision medicine with the stratification of diseases into distinct disease subsets, specific diagnoses, and targeted treatment options, including biologicals and small molecules.This article reviews recent developments in research and patient care and future trends in the discipline. The section on basic mechanisms of allergic diseases summarizes the current status and defines research needs in structural biology, type 2 inflammation, immune tolerance, neuroimmune mechanisms, role of the microbiome and diet, environmental factors, and respiratory viral infections. In the section on diagnostic challenges, clinical trials, precision medicine and immune monitoring Zuzana Diamanthttps://orcid.org/0000-0003-0133-0100Thomas Eiwegger https://orcid.org/0000-0002-2914-7829Wytske J. Fokkens https://orcid.org/0000-0003-4852-229X

show abstract

“…Lipid metabolites are a new target for monitoring of AIT. 76,77 Specifically, release by immune cells of 15-hydroxyeicosatetraenoic acid and lipoxin A4 is upregulated following AIT, and potentially, these products can be measured in serum. 78,79…”

Section: Cytokines Chemokines and Other Soluble Moleculesmentioning

confidence: 99%

Recent developments and highlights in immune monitoring of allergen immunotherapy

Zelm

McKenzie

Varese

et al. 2019

Allergy

View full text Add to dashboard Cite

Allergic diseases are the most common chronic immune-mediated disorders and can manifest with an enormous diversity in clinical severity and symptoms. Underlying mechanisms for the adverse immune response to allergens and its downregulation by treatment are still being revealed. As a result, there have been, and still are, major challenges in diagnosis, prediction of disease progression/evolution and treatment.Currently, the only corrective treatment available is allergen immunotherapy (AIT).AIT modifies the immune response through long-term repeated exposure to defined doses of allergen. However, as the treatment usually needs to be continued for several years to be effective, and can be accompanied by adverse reactions, many patients face difficulties completing their schedule. Long-term therapy also potentially incurs high costs. Therefore, there is a great need for objective markers to predict or to monitor individual patient's beneficial changes in immune response during therapy so that efficacy can be identified as early as possible. In this review, we specifically address recent technical developments that have generated new insights into allergic disease pathogenesis, and how these could potentially be translated into routine laboratory assays for disease monitoring during AIT that are relatively inexpensive, robust and scalable. K E Y W O R D Sallergen immunotherapy, allergy, biomarker, immune monitoring | 2343 ZELM Et aL.

show abstract

Multi‐omics analysis points to altered platelet functions in severe food‐associated respiratory allergy

Abstract: We have found evidence that points to the association of severe allergic inflammation with platelet functions alteration, together with reduced protein synthesis, and switch of immune cells to aerobic glycolysis.

Cited by 67 publications

References 67 publications

Untargeted metabolomic profiling identifies disease-specific signatures in food allergy and asthma

Untargeted metabolomic profiling identifies disease-specific signatures in food allergy and asthma

Future research trends in understanding the mechanisms underlying allergic diseases for improved patient care

Recent developments and highlights in immune monitoring of allergen immunotherapy

Contact Info

Product

Resources

About