2010
DOI: 10.1177/030089161009600532 View full text |Buy / Rent full text
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Abstract: The WHO definition of the 3 classes of well differentiated endocrine tumor, well differentiated endocrine carcinoma and poorly differentiated carcinoma, allows an efficient general classification of GEP NETs fitting European Union (EU) current clinical use. The ENETS grading and TNM staging systems are complementary tools allowing to improve patients' stratification, and their adoption is strongly recommended. However, the prognostic value of these tools is still under investigation and more data are needed to… Show more

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“…Poorly differentiated NET or G3-NEC according to the digestive WHO 2010 Classification (Rindi 2010) is a rare and aggressive disease for which urgent therapeutic intervention is required as soon as the diagnosis is confirmed by expert pathologists. G3-NEC patients enrolled in this study were reviewed to ensure that the Four-month PFS was 50%, 95% CI (30-70%) and six-month PFS was 20%, 95% CI (8-41%).…”
Section: Discussionmentioning
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“…Poorly differentiated NET or G3-NEC according to the digestive WHO 2010 Classification (Rindi 2010) is a rare and aggressive disease for which urgent therapeutic intervention is required as soon as the diagnosis is confirmed by expert pathologists. G3-NEC patients enrolled in this study were reviewed to ensure that the Four-month PFS was 50%, 95% CI (30-70%) and six-month PFS was 20%, 95% CI (8-41%).…”
Section: Discussionmentioning
“…Poorly differentiated neuroendocrine carcinomas (NECs) are characterized by a poorer outcome when compared with well-differentiated NET independently of the TNM stage or the primary location (Madeira et al 1998, Travis et al 1998, Rindi et al 1999, Lim et al 2005, Asamura et al 2006, Faggiano et al 2007, Scarpa et al 2010, Panzuto et al 2011, Strosberg et al 2011. These tumors, when located in the digestive system, are classified as WHO grade 3 NEC (G3-NEC), characterized by a poorly differentiated morphology, a mitotic count above 20/10 high-power field (10 HPF), and/or a Ki67 expression level exceeding 20% (Rindi 2010). Our group has recently reported that the grade 3 NET (G3-NET) category should also be considered, as some tumors, with a mitotic count above 20/10 HPF and/or a Ki67 expression level of over 20%, present a welldifferentiated morphology and more importantly different prognosis and behavior (Vélayoudom-Céphise et al 2013).…”
Section: Introductionmentioning
“…Tumors were classified according to the current TNM staging and grading system for NET (6)(7)(8). All tumors were well-differentiated endocrine tumors, according to histopathology, with the presence of distant metastases (TNM stage IV).…”
Section: Histopathologymentioning
“…Patients were classified according to the current TNM staging and grading system for NENs (1,2,21). All tumors were NENs with distant metastases (TNM stage IV).…”
Section: Histopathology and Tumor Gradingmentioning