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“…Amalgamation of structural elements from two or more bioactive compounds into a hybrid structure is an attractive strategy in the design of functional analogues. In principle, such hybrids can expedite syntheses through simplified structures, provide mechanistic insight, and advantageously modulate properties like bioavailability, stability, and selectivity. A structure of interest in this context is the polyether ionophore salinomycin (SA, Figure ). In addition to its industrial use as an anticoccicide and growth promoter, this compound and its more active semisynthetic analogues have been shown to efficiently and selectively inhibit properties associated with breast cancer stem cells (CSC). More recently, SA has also been shown to reduce scarring during wound healing .…”
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“…Amalgamation of structural elements from two or more bioactive compounds into a hybrid structure is an attractive strategy in the design of functional analogues. In principle, such hybrids can expedite syntheses through simplified structures, provide mechanistic insight, and advantageously modulate properties like bioavailability, stability, and selectivity. A structure of interest in this context is the polyether ionophore salinomycin (SA, Figure ). In addition to its industrial use as an anticoccicide and growth promoter, this compound and its more active semisynthetic analogues have been shown to efficiently and selectively inhibit properties associated with breast cancer stem cells (CSC). More recently, SA has also been shown to reduce scarring during wound healing .…”
mentioning
“…We therefore hypothesized that the replacement of the C3 OH group in lincomycin by a dimethylamino group as in 10 would result in a stronger charge interaction with PO 4 2505, hopefully leading to a more potent antibiotic. [50] Much to our surprise, the synthetic 3-dimethylaminolincomycin hybrid structure 10 was found to display no inhibition of the growth of E. coli or S. aureus at concentrations of 10 mm. However, against the same organisms, lincomycin (1) showed MIC values of > 10 mm and 3-5 mg mL…”
Section: 12mentioning
“…Another interesting approach to hybrid antibacterial drugs has been reported by Hanessian and Kothakonda [50]. Their 3- The application of dual action drugs has also penetrated the world of algicides [52].…”
Section: Other Dual Action Prodrugsmentioning