(−)-3,5-Dicaffeoyl-muco-quinic acid isolated from Aster scaber contributes to the differentiation of PC12 cells: through tyrosine kinase cascade signaling

Hur, Jin Young; Lee, Pyeongjae; Kim, Ho-Cheol; Kang, Insug; Lee, Kang Ro; Kim, Sun Yeou

doi:10.1016/j.bbrc.2003.11.178

Cited by 30 publications

(18 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This suggests that the observed potentiation of NGF by GTPP and EGCG was unlikely caused by the additional contribution to ERK activity. Previous studies have shown an induction of ERK activation by some naturally occurring compounds correlating with their ability to induce neurite outgrowth, and that the blocking of this pathway results in inhibition of neuritogenesis induced by these agents (Hur et al, 2004; Ina et al, 2007; Kano et al, 2008; Sagara et al, 2004). Some agents which potentiate NGF-induced neuritogenesis lack their own ability to induce ERK activity and yet prolong ERK activation induced by a suboptimal concentration of NGF (Qi et al, 2006).…”

Section: Discussionmentioning

confidence: 98%

Green tea polyphenols potentiate the action of nerve growth factor to induce neuritogenesis: Possible role of reactive oxygen species

Gundimeda

McNeill

Schiffman

et al. 2010

J of Neuroscience Research

View full text Add to dashboard Cite

Exogenously administered nerve growth factor (NGF) repairs injured axons, but it does not cross the blood-brain barrier. Thus, agents that could potentiate the neuritogenic ability of endogenous NGF would be of great utility in treating neurological injuries. Using the PC12 cell model, here we show that unfractionated green tea polyphenols (GTPP) at low concentrations (0.1 μg/ml) potentiate the ability of low concentrations of NGF (2 ng/ml) to induce neuritogenesis at a level comparable to that induced by optimally high concentrations of NGF (50 ng/ml) alone. In our experiments, GTPP by itself did not induce neuritogenesis or increase immunofluorescent staining for β-tubulin III; however, it increased expression of mRNA and proteins for the neuronal markers neurofilament-L and GAP-43. Among the polyphenols present in GTPP, epigallocatechin-3-gallate (EGCG) alone appreciably potentiated NGF-induced neurite outgrowth. Although other polyphenols present in GTPP, particularly epigallocatechin and epicatechin, lack this activity, they synergistically promoted this action of EGCG. GTPP also induced an activation of extracellular signal-regulated kinases (ERKs). PD98059, an inhibitor of the ERK pathway, blocked the expression of GAP-43. K252a, an inhibitor of TrkA-associated tyrosine kinase, partially blocked the expression of these genes and ERK activation. Antioxidants, catalase (cell-permeable form) and N-acetylcysteine (both L and D-forms) inhibited these events and abolished GTPP potentiation of NGF-induced neuritogenesis. Taken together, these results show for the first time that GTPP potentiates NGF-induced neuritogenesis likely through the involvement of sublethal levels of reactive oxygen species and suggest that unfractionated GTPP is more effective in this respect than its fractionated polyphenols.

show abstract

Section: Discussionmentioning

confidence: 98%

Green tea polyphenols potentiate the action of nerve growth factor to induce neuritogenesis: Possible role of reactive oxygen species

Gundimeda

McNeill

Schiffman

et al. 2010

J of Neuroscience Research

View full text Add to dashboard Cite

show abstract

“…where each monoacyl chlorogenic acid subgroup was dominated by the 5-acyl isomer. It has been reported that Aster scaber (Hur et al, 2004) synthesises chlorogenic acids derived from muco-quinic acid. Such chlorogenic acids possess an extra equatorial hydroxyl residue and elute more rapidly than the analogous derivatives of the more commonly encountered quinic acid (Haribal et al, 1998).…”

Section: Chlorogenic Acids Sought But Not Foundmentioning

confidence: 99%

“…In addition, Aster scaber has been reported to contain the 3,5dicaffeoyl ester of muco-quinic acid (in which the C3 hydroxyl is equatorial rather than axial; Fig. 1) in addition to the better known 5-caffeoylquinic acid, 3,5-dicaffeoylquinic acid and 4,5-dicaffeoylquinic acid (Kwon et al, 2000;Hur et al, 2004). The chlorogenic acids of Aster spp.…”

Section: Introductionmentioning

confidence: 99%

Profiling the chlorogenic acids of aster by HPLC–MSn

2006

View full text Add to dashboard Cite

Using HPLC-MS(n), 33 chlorogenic acids were identified in an aqueous-alcoholic extract of Aster ageratoides Turcz. flower buds. These were three isomers each of p-coumaroylquinic acid, caffeoylquinic acid, feruloylquinic acid, dicaffeoylquinic acid and diferuloylquinic acid, and six isomers each of p-coumaroyl-caffeoylquinic acid, p-coumaroyl-feruloylquinic acid and caffeoyl-feruloylquinic acid. Only the caffeoylquinic acids and dicaffeoylquinic acids have been reported previously in Asteraceae. Three of the six p-coumaroyl-feruloylquinic acids (3-feruloyl-4-p-coumaroylquinic acid, '3-feruloyl-5-p-coumaroylquinic acid and 4-feruloyl-5-p-coumaroylquinic acid) have not been observed previously in nature. Cis-5-p-coumaroylquinic acid was identified at a concentration ca 25% that of the more common trans isomer. The feruloylquinic acids and diferuloylquinic acids dominated the mono- and di-acyl chlorogenic acid fractions, respectively, making this plant material a useful source of these commercially non-available substances. These 33 chlorogenic acids were not detected in the leaves or stem of A. ageratoides Turcz., or in the flower buds of A. ageratoides Turcz. var. Gerla or A. kalimeris indica (L) Sch. Bip. Only the feruloylquinic acids were detected in the root of A. ageratoides Turcz. It was not possible to detect any 1-acyl chlorogenic acids, any chlorogenic acids with a succinic acid substituent, or any chlorogenic acids based on muco-quinic acid.

show abstract

“…1) Some triterpene glycosides and volatile compounds have been isolated from A. scaber. [1][2][3] Recently, several studies have demonstrated that A. scaber contains various pharmacologically active compounds with anti-Alzheimer's disease, 4,5) antioxidant, 6,7) and antihuman immunodeficiency virus-1 effects. 8) In vitro plant tissue culture has many potential applications for the production of biologically active phytochemicals and for genetic improvement through genetic engineering.…”

mentioning

confidence: 99%

In vitro plant regeneration of Aster scaber via somatic embryogenesis

Boo

Cao

Pamplona

et al. 2015

Bioscience, Biotechnology, and Biochemistry

View full text Add to dashboard Cite

We established an in vitro plant regeneration system via somatic embryogenesis of Aster scaber, an important source of various biologically active phytochemicals. We examined the callus induction and embryogenic capacities of three explants, including leaves, petioles, and roots, on 25 different media containing different combinations of α-naphthalene acetic acid (NAA) and 6-benzyladenine (BA). The optimum concentrations of NAA and BA for the production of embryogenic calli were 5.0 μM and 0.05 μM, respectively. Media containing higher concentrations of auxin and cytokinin (such as 25 μM NAA and 25 μM BA) were suitable for shoot regeneration, especially for leaf-derived calli, which are the most readily available calli and are highly competent. For root induction from regenerated shoots, supplemental auxin and/or cytokinin did not improve rooting, but instead caused unwanted callus induction or retarded growth of regenerated plants. Therefore, plant growth regulator-free medium was preferable for root induction. Normal plants were successfully obtained from calli under the optimized conditions described above. This is the first report of the complete process of in vitro plant regeneration of A. scaber via somatic embryogenesis.

show abstract

(−)-3,5-Dicaffeoyl-muco-quinic acid isolated from Aster scaber contributes to the differentiation of PC12 cells: through tyrosine kinase cascade signaling

Cited by 30 publications

References 20 publications

Green tea polyphenols potentiate the action of nerve growth factor to induce neuritogenesis: Possible role of reactive oxygen species

Green tea polyphenols potentiate the action of nerve growth factor to induce neuritogenesis: Possible role of reactive oxygen species

Profiling the chlorogenic acids of aster by HPLC–MSn

In vitro plant regeneration of Aster scaber via somatic embryogenesis

Contact Info

Product

Resources

About