Biochemical Pharmacology volume 78, issue 5, P469-476 2009 DOI: 10.1016/j.bcp.2009.05.008 View full text
Omar I. Vivar, Chia-Lei Lin, Gary L. Firestone, Leonard F. Bjeldanes

Abstract: 3,3′-Diindolylmethane (DIM) is a potential chemopreventive phytochemical derived from Brassica vegetables. In this study we characterized the effect of DIM on cell cycle regulation in both androgen dependent LNCaP and androgen receptor negative-p53 mutant DU145 human prostate cancer cells. DIM had an antiproliferative effect on both LNCaP and DU145 cells, as it significantly inhibited [3H]-thymidine incorporation. FACS analysis revealed a DIM mediated G1 cell cycle arrest. DIM strongly inhibited the expressio…

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