3.033 THE AGGREGATED WT-α-SYNUCLEIN AND A53T PROMOTE INFLAMMATION THROUGH ACTIVATION OF NADPH OXIDASE COMPLEX IN BV-2 AND PRIMARY MICROGLIA

Kang, Wenyan; Liu, J.; Chen, S.

doi:10.1016/s1353-8020(11)70769-6

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“…The regulation of cytokine by cytokine–cytokine receptor interaction could trigger neuroactive ligand–receptor interaction and NF‐kappa B signaling pathway (Chen et al ., ; Jobin et al ., ). From the descriptions above, we could speculate that α‐synuclein‐mediated activation of inflammation in neurodegeneration (Kang et al ., ) may be correlated with its dysregulation on these three pathways. Besides these significantly dysregulated pathways above, we can observe that α‐synuclein overexpression could also affect some other important pathways to a certain extent (Fig.…”

Section: Discussionmentioning

confidence: 99%

Microarray Expression Analysis for the Paradoxical Roles ofAcanthopanax senticosusHarms in Treating α-Synucleinopathies

Zhang

Lü

et al. 2015

Phytother. Res.

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α-Synuclein is a key player in the pathogenesis of neurodegenerative disorders with Lewy bodies. Our previous studies have also showed that Acanthopanax senticosus harms (AS) could significantly suppress α-synuclein overexpression and toxicity. Identifying the RNAs related to α-synucleinopathies may facilitate understanding the pathogenesis of the diseases and the safe application of AS in the clinic. Microarray expression profiling of long non-coding RNAs (lncRNAs) and mRNAs was undertaken in control non-transgenic and human α-synuclein transgenic mice. The effects of AS on central nervous system (CNS) in pathology and physiology were investigated based on the lncRNA/mRNA targets analysis. In total, 341 lncRNAs and 279 mRNAs were differentially expressed by α-synuclein stimulus, among which 29 lncRNAs and 25 mRNAs were involved in the anti-α-synucleinopathies mechanism of AS. However, the levels of 19/29 lncRNAs and 12/25 mRNAs in AS group were similar to those in α-synuclein group, which may cause potential neurotoxicity analogous to α-synuclein. This study demonstrated that some of lncRNAs/mRNAs were involved in α-synuclein related pathophysiology, and AS produced the bidirectional effects on CNS under pathological and physiological conditions.

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Section: Discussionmentioning

confidence: 99%