2D transition metal carbide MXene as a robust biosensing platform for enzyme immobilization and ultrasensitive detection of phenol

Wu, Lingxia; Lu, Xianbo; Dhanjai,; Wu, Zhong‐Shuai; Dong, Yanfeng; Wang, Xiaohui; Zheng, Shuilin; Chen, Jiping

doi:10.1016/j.bios.2018.02.021

Cited by 288 publications

(112 citation statements)

References 43 publications

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“…The unique 2D morphology and high biocompatibility of Ti 3 C 2 T x drive great motivation to design advanced nanohybrid systems with bioreceptors like antigen–antibody, proteins, cells, and enzymes . Ti 3 C 2 T x acts as sensitive detection interface that allows facile immobilization of biomolecules for designing highly advanced detection systems and exploiting their utilization in analytical chemistry . Nonetheless, achieving the desired signal‐to‐noise ratio and stability for such sensors, especially for in situ detection, remains highly challenging.…”

Section: Introductionmentioning

confidence: 99%

A MXene‐Based Wearable Biosensor System for High‐Performance In Vitro Perspiration Analysis

Lei

Zhao

Zhang

et al. 2019

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Wearable electrochemical biosensors for sweat analysis present a promising means for noninvasive biomarker monitoring. However, sweat‐based sensing still poses several challenges, including easy degradation of enzymes and biomaterials with repeated testing, limited detection range and sensitivity of enzyme‐based biosensors caused by oxygen deficiency in sweat, and poor shelf life of sensors using all‐in‐one working electrodes patterned by traditional techniques (e.g., electrodeposition and screen printing). Herein, a stretchable, wearable, and modular multifunctional biosensor is developed, incorporating a novel MXene/Prussian blue (Ti3C2Tx/PB) composite designed for durable and sensitive detection of biomarkers (e.g., glucose and lactate) in sweat. A unique modular design enables a simple exchange of the specific sensing electrode to target the desired analytes. Furthermore, an implemented solid–liquid–air three‐phase interface design leads to superior sensor performance and stability. Typical electrochemical sensitivities of 35.3 µA mm−1 cm−2 for glucose and 11.4 µA mm−1 cm−2 for lactate are achieved using artificial sweat. During in vitro perspiration monitoring of human subjects, the physiochemistry signals (glucose and lactate level) can be measured simultaneously with high sensitivity and good repeatability. This approach represents an important step toward the realization of ultrasensitive enzymatic wearable biosensors for personalized health monitoring.

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Section: Introductionmentioning

confidence: 99%

A MXene‐Based Wearable Biosensor System for High‐Performance In Vitro Perspiration Analysis

Lei

Zhao

Zhang

et al. 2019

Small

323

218

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“…Compared to other 2D materials, MXenes possess a unique combination of excellent electrical conductivity, hydrophilicity, potential for high density incorporation of several functional groups, ultrathin 2D sheet-like morphology as well as excellent ion intercalation behavior which are ideal for electrochemical sensing. So far, biosensors based on MXenes have been focused on the detection of nitrite, pesticides, phenol and H 2 O 2 (Liu et al 2015;Wang et al 2015a; Wang et al 2015b;Wu et al 2018;Zhou et al 2017). These biosensors used multilayered Ti 3 C 2 -MXene systems to immobilize electrochemical active proteins via physical adsorption.…”

Section: Introductionmentioning

confidence: 99%

Biofunctionalized two-dimensional Ti3C2 MXenes for ultrasensitive detection of cancer biomarker

Kumar

Lei

Alshareef

et al. 2018

Biosensors and Bioelectronics

352

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In this work, ultrathin TiC-MXene nanosheets were synthesized by minimally intensive layer delamination methods, and uniformly functionalized with aminosilane (f-TiC-MXene) to provide a covalent binding for the immobilized bio-receptor (anti-CEA) for label free, ultrasensitive detection of cancer biomarker (carcinoembryonic antigen, CEA). The effect of different redox probes on the electrochemical behavior of f-TiC-MXene was investigated and found that hexaammineruthenium ([Ru(NH)]) is the preferable redox probe for biosensing. The fabricated biofunctionalized TiC-MXene exhibits a linear detection range of 0.0001-2000 ng mL with sensitivity of 37.9 µA ng mL cm per decade. The wider linear detection range of our f-TiC-MXene is not only higher than previously reported pristine 2D nanomaterials, but is even comparable to other hybrid 2D nanomaterials. We believe that this work opens a new window for development of MXene-based highly sensitive DNA, aptamer, enzyme, antibody, and cell based biosensors, and could be further used in drug delivery application.

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“…Wu et al . explored MXene as a new matrix to immobilize the enzyme tyrosinase for fabricating a mediator‐free biosensor for ultrasensitive and rapid detection of phenol. The biosensor exhibited a wide linear range from 0.05 to 15.5 μM, with a low LOD of 12 nM and a sensitivity of 414.4 mA M −1 .…”

Section: Application Of Mxene In Biosensingmentioning

confidence: 99%

“…Alternatively amine groups of chitosan can be then applied for covalent immobilization of proteins using glutaraldehyde as a crosslinker [25]. The enzyme can be delivered on the interface directly from a mixture of the enzyme and chitosan [26] or from a mixture containing MXene, enzyme and chitosan in one step [27].…”

Section: Deposition Of Mxene On Surfacesmentioning

confidence: 99%

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2D MXenes as Perspective Immobilization Platforms for Design of Electrochemical Nanobiosensors

et al. 2019

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MXenes are a new group of 2D nanomaterials with fascinating properties including high electrical conductivity, hydrophilic nature, easily tunable structure and high surface area. This is why MXene modified interfaces are extremely promising for the preparation of sensitive electrochemical biosensors. While there are numerous reports on MXene‐based enzymatic biosensors for detection of a wide range of analytes, application of MXene for construction of affinity biosensors is in its infancy. The review article summarizes current state‐of the‐art in the field with a focus on MXene modifications needed for construction of robust and high performance MXene electrochemical biosensors.

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2D transition metal carbide MXene as a robust biosensing platform for enzyme immobilization and ultrasensitive detection of phenol

Cited by 288 publications

References 43 publications

A MXene‐Based Wearable Biosensor System for High‐Performance In Vitro Perspiration Analysis

A MXene‐Based Wearable Biosensor System for High‐Performance In Vitro Perspiration Analysis

Biofunctionalized two-dimensional Ti3C2 MXenes for ultrasensitive detection of cancer biomarker

2D MXenes as Perspective Immobilization Platforms for Design of Electrochemical Nanobiosensors

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