Food Exclusion Based on IgG Antibodies Alleviates Symptoms in Ulcerative Colitis: A Prospective Study

Liu, Jian; He, Anbang; Liu, Gang; Litian, Wang; Xu, Yiting; Wang, Mengdi; Liu, Tong

doi:10.1093/ibd/izy110

Cited by 23 publications

(19 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…This study demonstrated that the positive rate of food-specific IgG in the blood of APEP was up to 52.3%, generally with mild to moderate elevation of antibody titer, which was lower than that of ulcerative colitis (57.5%-70.1%), Crohn disease (90.72%) [4,16,23]and food-specific IgGs associated with clinically allergic symptoms [24]. Such differences indicate that food-specific IgG with a higher positive rate and a greater titer may be associated with some morbid states, but it is not clear whether the disease results in an increase of IgG positive rate or food-specific IgG induces the morbid state.…”

Section: Discussionmentioning

confidence: 69%

“…At present, the role of food-specific IgG in the health of human body remains controversial. Numerous studies have suggested that food-specific IgG is involved in the development and progression of some diseases, such as inflammatory bowel disease [1][2][3][4]， irritable bowel syndrome [5], migraine [6,7]and mental disease [8][9][10][11], of which the symptoms can be relieved by food-specific IgG-based diet recommendations [12][13][14][15][16][17]. IgG antibody can form an immune complex with allergens in foods and thus induce the body's mild inflammatory reactions [18] that are manifested as various system symptoms and diseases.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Effects of Food-Specific IgG on Health Outcomes of Asymptomatic Physical Examination Population

Wang

Sun

et al. 2021

Preprint

View full text Add to dashboard Cite

Background: Although food-specific IgG is associated with the development and progression of some diseases as shown by many studies, it is also present in the population without clinical symptoms. However, the damage of the immune response it evokes to the health of such population has not been studied yet.Methods: The asymptomatic physical examination population (APEP) was selected according to the inclusion and exclusion criteria, and the physical examination data were collected. The subjects were divided into IgG-positive group (IgG-po group) and IgG-negative group (IgG-neg group). The hematologic and imaging examination results were compared between the two groups, and their odds ratios (OR) and 95% confidence interval (95%CI) were calculated using binary logistic regression to determine the relationship between food-specific IgG and different health outcomes. Results: The data of 28,292 subjects were included in the analysis of the study. The overall IgG positive rate was up to 52.3%, with mild to moderate IgG positive predominantly. Compared with IgG negative group, IgG positive group was associated with a decrease in the risks of hypertriglyceridemia, abnormal fasting blood glucose and overweight(OR=0.87,95%:CI:0.83-0.92; OR=0.93,95%CI:0.87-0.99; OR=0.92,95%CI:0.87-0.96) and with an increase in the incidence rate of thyroid nodule (OR=1.09,95%CI:1.04-1.15).Conclusion: Food-specific IgG is generally present in APEP and has an unique distribution profile, which plays a positive role in maintaining normal body weight and metabolic indicators(triglyceride(TG) and fasting blood glucose(FBG)), without influencing the nutritional status. The physiological mechanism is worth further study.

show abstract

Section: Discussionmentioning

confidence: 69%

Section: Introductionmentioning

confidence: 99%

Effects of Food-Specific IgG on Health Outcomes of Asymptomatic Physical Examination Population

Wang

Sun

et al. 2021

Preprint

View full text Add to dashboard Cite

show abstract

“…After title and abstract screening, nine studies were selected for full-text review. Following the full-text review, seven randomized controlled trials that met the inclusion and exclusion criteria were selected for this review [35,36,37,38,39,40,41]. The general characteristics of the included studies are summarized in Table 1.…”

Section: Resultsmentioning

confidence: 99%

“…In a recent open-label, stratified study, Jian et al [41] randomly allocated 97 UC patients who were in remission or had mild to moderate disease activity to a food exclusion group versus a sham diet group. At baseline, the presence of blood IgG antibodies specific to egg, wheat, milk, corn, tomato, crab, rice, soybean, cod, shrimp, mushrooms, beef, chicken, and pork antigens were tested.…”

Section: Resultsmentioning

confidence: 99%

“…In this review, we also included three other studies that recruited patients with active disease and UC remission concurrently. They reported the effectiveness of comprehensive dietary advices [38], low FODMAP [40] or IgG-guided exclusion diets [41] in reduction of disease activity in UC patients. Although these findings are encouraging, one of the major limitations of these studies is that they did not report their findings for patients with active disease versus patients in UC remission separately to allow meaningful interpretations [45].…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Diet in the Pathogenesis and Management of Ulcerative Colitis; A Review of Randomized Controlled Dietary Interventions

2019

View full text Add to dashboard Cite

Epidemiological and experimental studies have suggested that diet is one of the environmental factors that contributes to the onset and pathophysiology of ulcerative colitis. Although many patients suffering from ulcerative colitis attribute their symptoms or disease relapse to dietary factors, only a few well-designed randomized controlled trials have been done to investigate the role of diet in the management of ulcerative colitis. Here, we review the potential mechanisms of the relationship between diet and pathogenesis of ulcerative colitis and summarize randomized controlled dietary interventions that have been conducted in ulcerative colitis patients.

show abstract

Precision nutrition in pediatric IBD: A position paper from the ESPGHAN special interest group for basic science and translational research, the IBD Porto group, and allied health professionals

Gerasimidis,

Russell,

Giachero

et al. 2023

J. pediatr. gastroenterol. nutr.

View full text Add to dashboard Cite

Stratified and precision nutrition refers to disease management or prevention of disease onset, based on dietary interventions tailored to a person's characteristics, biology, gut microbiome, and environmental exposures. Such treatment models may lead to more effective management of inflammatory bowel disease (IBD) and reduce risk of disease development. This societal position paper aimed to report advances made in stratified and precision nutritional therapy in IBD. Following a structured literature search, limited to human studies, we identified four relevant themes: (a) nutritional epidemiology for risk prediction of IBD development, (b) food‐based dietary interventions in IBD, (c) exclusive enteral nutrition (EEN) for Crohn's disease (CD) management, and (d) pre‐ and probiotics for IBD management. There is scarce literature upon which we can make recommendations for precision or stratified dietary therapy for IBD, both for risk of disease development and disease management. Certain single‐nucleotide polymorphisms related to polyunsaturated fatty acid (PUFA) metabolism may modify the effect dietary PUFA have in increasing the risk of IBD development. Non‐colonic CD, mild‐to‐moderate CD, and high microbiota richness may predict success of EEN and may be used both for prediction of treatment continuation, but also for early cessation in nonresponders. There is currently insufficient evidence to make recommendations for precision or stratified dietary therapy for patients with established IBD. Despite the great interest in stratified and precision nutrition, we currently lack data to support conclusive recommendations. Replication of early findings by independent research groups and within structured clinical interventions is required.

show abstract

Food Exclusion Based on IgG Antibodies Alleviates Symptoms in Ulcerative Colitis: A Prospective Study

Abstract: An IgG-guided exclusion diet ameliorated UC symptoms and improved QoL. Interactions between IgG-based food intolerance and UC warrant further study.

Cited by 23 publications

References 22 publications

Effects of Food-Specific IgG on Health Outcomes of Asymptomatic Physical Examination Population

Effects of Food-Specific IgG on Health Outcomes of Asymptomatic Physical Examination Population

Diet in the Pathogenesis and Management of Ulcerative Colitis; A Review of Randomized Controlled Dietary Interventions

Precision nutrition in pediatric IBD: A position paper from the ESPGHAN special interest group for basic science and translational research, the IBD Porto group, and allied health professionals

Contact Info

Product

Resources

About