Food-specific IgGs Are Highly Increased in the Sera of Patients with Inflammatory Bowel Disease and Are Clinically Relevant to the Pathogenesis

Xiao, Ning; Li, Fenghua; Zhou, Guangxi; Sun, Mingming; Ai, Fengfu; Liu, Zhanju

doi:10.2169/internalmedicine.9377-17

Cited by 17 publications

(15 citation statements)

References 51 publications

(56 reference statements)

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“…It is reported that food allergy is involved in the UC pathogenesis [14, 15]. Thus, we investigate a possible link between the high PMN activities associating with UC relapse and the food allergy status in the colon.…”

Section: Resultsmentioning

confidence: 99%

FcγRI plays a critical role in patients with ulcerative colitis relapse

Zhang

Yang

et al. 2020

Eur J Immunol

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Ulcerative colitis (UC) is a disease that frequently relapses and affects more than 0.1% general population; the underlying mechanism is poorly understood. Published data show that polymorphonuclear neutrophils (PMN) contribute to the pathogenesis of UC. This study aims to identify antigen (Ag)‐specific PMNs and investigate their role in UC relapse. In this study, the correlation between PMN activities and UC relapse was assessed in a group of UC patients. A UC mouse model was developed to expand the findings of UC patient study. The results showed that a positive correlation was detected between the high PMN activities and the food Ag‐specific IgG amounts in colon biopsies of UC patients. UC patient‐derived Ag‐specific PMNs could be activated upon exposure to food specific Ag. The Ag/FcγRI complexes were detected on the surface of PMNs in UC patients. Re‐exposure of sensitized PMNs to specific Ag triggered PMN activation and induced UC‐like inflammation in the mouse colon. We conclude that FcγRI plays a critical role in UC relapse. Inhibition of FcγRI can efficiently inhibits experimental UC.

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Section: Resultsmentioning

confidence: 99%

FcγRI plays a critical role in patients with ulcerative colitis relapse

Zhang

Yang

et al. 2020

Eur J Immunol

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“…In further support of a link between food allergy and IBD, IgE has been associated with the pathogenesis of both disorders: Accordingly, patients with allergies have an altered response of IgE to innocuous antigens and, in IBD patients, eosinophilia has been suggested to be mediated by IgE [ 55 ]. Moreover, an increased level of food-specific IgGs in comparison with healthy subjects has been described in CD patients [ 56 ]. Importantly, at present, no clear functional data has been reported to causally link food allergies to the disease course of IBD.…”

Section: The Role Of Type 2 Immunity In Ibdmentioning

confidence: 99%

The Regulation of Intestinal Inflammation and Cancer Development by Type 2 Immune Responses

Gámez‐Belmonte

Erkert

Wirtz

et al. 2020

IJMS

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The gut is among the most complex organs of the human body. It has to exert several functions including food and water absorption while setting up an efficient barrier to the outside world. Dysfunction of the gut can be life-threatening. Diseases of the gastrointestinal tract such as inflammatory bowel disease, infections, or colorectal cancer, therefore, pose substantial challenges to clinical care. The intestinal epithelium plays an important role in intestinal disease development. It not only establishes an important barrier against the gut lumen but also constantly signals information about the gut lumen and its composition to immune cells in the bowel wall. Such signaling across the epithelial barrier also occurs in the other direction. Intestinal epithelial cells respond to cytokines and other mediators of immune cells in the lamina propria and shape the microbial community within the gut by producing various antimicrobial peptides. Thus, the epithelium can be considered as an interpreter between the microbiota and the mucosal immune system, safeguarding and moderating communication to the benefit of the host. Type 2 immune responses play important roles in immune-epithelial communication. They contribute to gut tissue homeostasis and protect the host against infections with helminths. However, they are also involved in pathogenic pathways in inflammatory bowel disease and colorectal cancer. The current review provides an overview of current concepts regarding type 2 immune responses in intestinal physiology and pathophysiology.

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“…Food antigens: Dietary antigens or allergens (substances present in food) are known to elicit immunologic reactions generally defined under the category of food hypersensitivity (FHS) [66]. Among the many types of reactions to food components, dietary cross-reactive antigen epitopes have often been associated with food allergies and food intolerances [67]. In literature, epitopes are implicitly assumed to exclusively consist of amino acids, but glycan epitopes and classical haptens are important IgE-binding epitopes [68].…”

Section: Food Glycans and Antigensmentioning

confidence: 99%

Blood Type Diets (BTD) and Aging: An Overview

Menapace¹

2019

J Aging Sci

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It has recently been proposed that glycans, being the third alphabet of life, interact intricately with endogenous biomolecules to modulate tolerance, immune and inflammatory responses. Specifically, food glycans could impact health and be a source of inflammation and age-related diseases. These special carbohydrates are present as glycoconjugates (glycoproteins or glycolipids) in and on the surface of all the cells (glycocalyx) of all organisms or are found in free form in biological fluids. Recent advances in glycobiology and glycochemistry have shown how glycans bind with naturally present human proteins (lectins), through protein-carbohydrate interactions (or PCI), but also how oligosaccharides can interact with other glycans, present throughout the human body (through carbohydrate-carbohydrate interactions, or CCI). Oligosaccharides present in food sources, which go beyond the definition of normal fibers, once ingested are then either absorbed in the bloodstream, where they are recognized by the immune system, or interact with the surface of GI epithelial cells, thus generating appropriate biochemical cascades that induce a tolerance or immune/inflammatory response. Because the ABO epitopes have been encountered on all human cells, not just erythrocytes and based on the different biotypology (A, AB, B, and O) impose morphic changes in the distribution of the glycans on the glycocalyx (lipid rafts and clustered saccharide patches), their CCI with food and microbe glycans will be different, thus, eliciting contrasting responses. This can explain the epidemiological data for blood type diets (BTD). Through continuous consumption of the wrong types of glycans, processes of chronic inflammation could be initiated and progress to accelerated aging. Four basic modes of action have been identified showing how glycans can trigger inflamm-aging. Since glycobiology is a young science, further studies with newer technologies are warranted for advancement in this field.

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Food-specific IgGs Are Highly Increased in the Sera of Patients with Inflammatory Bowel Disease and Are Clinically Relevant to the Pathogenesis

Cited by 17 publications

References 51 publications

FcγRI plays a critical role in patients with ulcerative colitis relapse

FcγRI plays a critical role in patients with ulcerative colitis relapse

The Regulation of Intestinal Inflammation and Cancer Development by Type 2 Immune Responses

Blood Type Diets (BTD) and Aging: An Overview

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