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Cited by 32 publications
(25 citation statements)
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“…Although numerous studies have reported the safety of using TXA with routine methods [17,23], the safety of supplemental dosages of TXA is still a matter of debate, as study has reported that there was an increased risk of DVT for higher doses of TXA or prolonged use [24]. However, currently, there is no consensus on whether the use of TXA increases the risk of postoperative lower limb DVT [4].…”
Section: Discussionmentioning
confidence: 99%
“…Although numerous studies have reported the safety of using TXA with routine methods [17,23], the safety of supplemental dosages of TXA is still a matter of debate, as study has reported that there was an increased risk of DVT for higher doses of TXA or prolonged use [24]. However, currently, there is no consensus on whether the use of TXA increases the risk of postoperative lower limb DVT [4].…”
Section: Discussionmentioning
confidence: 99%
“…The most effective result was obtained with the administration of multiple doses of the drugs to maintain active biological functions during the process of fibrinolysis, a theory that is consistent with that of some other authors. 2,40 A Cochrane review in 2011 concluded that TXA did not increase the risk of death, myocardial infarction, cerebrovascular accident, deep vein thrombosis, PE, or renal impairment. 53 In 2014, Poeran et al retrospectively analyzed outcome data for 872,416 TKA or THA patients and found no increase in thromboembolic events nor renal impairment with TXA use.…”
Section: Discussionmentioning
confidence: 99%
“…1 This significant amount of blood loss leads to swelling, hematoma formation, postoperative stiffness, and possible prolonged drainage, delaying rehabilitation, functional recovery, and hospital discharge, increasing health care costs, often leading to acute anemia and blood transfusion. 2 These features increase the risk of postoperative periprosthetic joint infection, transfusion-related acute lung injury, transfusion-associated circulatory overload, hemolytic transfusion reactions, delayed functional recovery, prolonged hospital stay, and even mortality. 3 Consequently, it is crucial to identify effective methods to minimize perioperative blood loss and reduce the rate of blood transfusion, indicating a need for a critical review of blood conservation practices to optimize operative costs and patient outcomes.…”
mentioning
confidence: 99%
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