2018
DOI: 10.1111/ele.12937
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Abstract: Epidemiological dynamics depend on the traits of hosts and parasites, but hosts and parasites are heterogeneous entities that exist in dynamic environments. Resource availability is a particularly dynamic and potent environmental driver of within-host infection dynamics (temporal patterns of growth, reproduction, parasite production and survival). We developed, parameterised and validated a model for resource-explicit infection dynamics by incorporating a parasitism module into dynamic energy budget theory. Th… Show more

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Cited by 43 publications
(67 citation statements)
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References 49 publications
(60 reference statements)
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“…Anthelmintic treatments increased 2‐week survival rates by 1.4% (Figure 1d; Table ), which compounds to a maximum of 2.4% after 2 months, and did not affect growth rates (Tables 1 and2; Figures 3 and 4). These small effects of parasitic worms on hosts were unexpected, given the potential costs of parasitic infections on hosts as host resources are consumed directly by parasites and additional energy is lost to immune defences and repair of tissues damaged by feeding, attachment and migration (Bonneaud et al., 2003; Civitello, Allman, Morozumi, & Rohr, 2018; Civitello, Fatima, Johnson, Nisbet, & Rohr, 2018; Cressler, Nelson, Day, & McCauley, 2014; Medzhitov, Schneider, & Soares, 2012). Frogs may have been able to compensate for energy lost to worms by increasing their food intake, as has been shown experimentally in captive Cuban treefrogs that were parasitized by A. hamatospicula (Knutie et al., 2017).…”
Section: Discussionmentioning
confidence: 99%
“…Anthelmintic treatments increased 2‐week survival rates by 1.4% (Figure 1d; Table ), which compounds to a maximum of 2.4% after 2 months, and did not affect growth rates (Tables 1 and2; Figures 3 and 4). These small effects of parasitic worms on hosts were unexpected, given the potential costs of parasitic infections on hosts as host resources are consumed directly by parasites and additional energy is lost to immune defences and repair of tissues damaged by feeding, attachment and migration (Bonneaud et al., 2003; Civitello, Allman, Morozumi, & Rohr, 2018; Civitello, Fatima, Johnson, Nisbet, & Rohr, 2018; Cressler, Nelson, Day, & McCauley, 2014; Medzhitov, Schneider, & Soares, 2012). Frogs may have been able to compensate for energy lost to worms by increasing their food intake, as has been shown experimentally in captive Cuban treefrogs that were parasitized by A. hamatospicula (Knutie et al., 2017).…”
Section: Discussionmentioning
confidence: 99%
“…Like their hosts, pathogenic organisms require energy resources to grow and reproduce. In food-restricted hosts, these resources may be reduced to levels that can limit pathogen growth (Civitello et al, 2018;Smith et al, 2005). For example, food-restricted zooplankton exposed to virulent fungal parasites died more slowly and exhibited fewer parasites than did wellfed ones (Hall et al, 2009).…”
Section: Introductionmentioning
confidence: 99%
“…which typically occurred between October and March. Beyond the problem of compensatory feedbacks, the observation of density feedbacks warrants the evaluation of the effect of reductions in snail populations in terms of transmission potential to humans as subject to non-linearities in cercarial productivity with resource availability [35,36]. Novel approaches leveraging DNA-based tools such as PCR for the identification of snail and schistosome species [3], as well as environmental-DNA (eDNA) quantification techniques recently developed for schistosomes can play in important role in investigating these issues [64].…”
Section: Discussionmentioning
confidence: 99%
“…First and foremost density feedbacks determine the strength of populations rebounds that can be expected after treatment, also called compensatory density feedbacks as highlighted for O. hupensis in different types of habitats in China [34]. In addition, the reduction of snail abundance in the presence of negative density feedback could lead in certain cases to a net increase in cercarial production by the remaining infected snails due to the resulting per capita increase in limited resources [35]. This nonlinear link between snail density and cercariogenesis could thus potentially undermine the aim of reducing transmission through snail control [36].…”
Section: Introductionmentioning
confidence: 99%