Viability and biocompatibility of an adhesive system for intrarenal embedding and endoscopic removal of small residual fragments in minimally-invasive stone treatment in an in vivo pig model

Abstract

For the first time, we demonstrated the proven feasibility and safety of this novel bioadhesive system for embedding and endoscopically removing small RF in conjunction with a lack of organ toxicity in vivo.

Fibrin gel‐assisted stone extraction in retrograde intrarenal surgery

“…In this study, we propose an effective strategy of using fibrin gel to retrieve small stone fragments during RIRS lithotripsy. Similar ideas of using stone adhesives have been previously reported in open pyelolithotomy that used autologous blood as a stone adhesive [ 5 ] and in an in vivo porcine kidney RIRS model that used a patented artificially synthesised polysaccharide‐based stone adhesive that required a specific solubiliser to be cleared from the collecting system [ 6 ].…”

Physical Techniques to Remove Residual Stone Fragments in the Urinary System

“…The mean removal time in the bioadhesive group was much shorter than that in the conventional group, indicating that this new approach for eliminating RF through the adhesive is practical. Another study [27] investigated the effect of a bioadhesive in four female domestic pigs under general anesthesia and discovered that it had no major adverse effects on live pigs and could encapsulate and eradicate 80–90% of RF. A prospective study [28] in a kidney model investigated the viability of extracting RF using a biocompatible stone binder.…”

Practical considerations in the use of a porcine model (Sus scrofa domesticus) to assess prevention of postoperative peritubal adhesions

“…Although most animal studies of postsurgical adhesions have used small animals (i.e. rats and rabbits) due to practical considerations [13], some research groups have elected to use porcine models because of their known efficiency-especially under laparoscopic conditions-and the potential to test prophylactic agents in more realistic conditions [14,15,16].…”