Enhanced antibacterial effect of azlocillin in conjugation with silver nanoparticles against
            <i>Pseudomonas aeruginosa</i>

Salouti, Mojtaba; Alizadeh, Hussain; Kazemizadeh, Ali Reza; Safari, Ali Asghar; Mahmazi, Sanaz

doi:10.1049/iet-nbt.2017.0009

Cited by 13 publications

(4 citation statements)

References 17 publications

(19 reference statements)

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“…The capacity to combat bacterial infections in vivo was probed in research using azlocillin in conjugation with AgNPs against P. aeruginosa. Along with evidencing the enhanced antibacterial effect of the antibiotic − AgNPs, this study demonstrated that azlocillin − AgNPs conjugate was able to reduce the colonization of P. aeruginosa in the spleen of mouse models [69]. Similarly, Ipe et al [70] carried out a more complex study in which, in addition to evaluating the combined bactericidal capacity of antibiotics and AgNPs, they evaluated their cytotoxicity to establish biocompatible doses with human fibroblasts.…”

Section: Agnps As An Alternative To Combat Human Pathogenic Bacteriamentioning

confidence: 83%

Silver Nanoparticles and Their Antibacterial Applications

Bruna

Maldonado-Bravo

Jara

et al. 2021

IJMS

760

340

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Silver nanoparticles (AgNPs) have been imposed as an excellent antimicrobial agent being able to combat bacteria in vitro and in vivo causing infections. The antibacterial capacity of AgNPs covers Gram-negative and Gram-positive bacteria, including multidrug resistant strains. AgNPs exhibit multiple and simultaneous mechanisms of action and in combination with antibacterial agents as organic compounds or antibiotics it has shown synergistic effect against pathogens bacteria such as Escherichia coli and Staphylococcus aureus. The characteristics of silver nanoparticles make them suitable for their application in medical and healthcare products where they may treat infections or prevent them efficiently. With the urgent need for new efficient antibacterial agents, this review aims to establish factors affecting antibacterial and cytotoxic effects of silver nanoparticles, as well as to expose the advantages of using AgNPs as new antibacterial agents in combination with antibiotic, which will reduce the dosage needed and prevent secondary effects associated to both.

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Section: Agnps As An Alternative To Combat Human Pathogenic Bacteriamentioning

confidence: 83%

Silver Nanoparticles and Their Antibacterial Applications

Bruna

Maldonado-Bravo

Jara

et al. 2021

IJMS

760

340

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“…The presence of the ionic silver was also shown to enhance antibacterial properties of hydrogen peroxide against P. aeruginosa biofilms [75]. Chemically conjugated antibiotics with AgNPs enhanced the antibacterial effect of the antibiotics [76,77]. In our study, the increased sensitivity of P. aeruginosa to tobramycin, when applied in combination with Ag(PiCO)-red and Ag(BTCO), provides a potential for preventative and therapeutic treatment against P. aeruginosa biofilm infections.…”

Section: Resultsmentioning

confidence: 61%

Polymeric Composites with Silver (I) Cyanoximates Inhibit Biofilm Formation of Gram-Positive and Gram-Negative Bacteria

et al. 2019

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Biofilms are surface-associated microbial communities known for their increased resistance to antimicrobials and host factors. This resistance introduces a critical clinical challenge, particularly in cases associated with implants increasing the predisposition for bacterial infections. Preventing such infections requires the development of novel antimicrobials or compounds that enhance bactericidal effect of currently available antibiotics. We have synthesized and characterized twelve novel silver(I) cyanoximates designated as Ag(ACO), Ag(BCO), Ag(CCO), Ag(ECO), Ag(PiCO), Ag(PICO) (yellow and red polymorphs), Ag(BIHCO), Ag(BIMCO), Ag(BOCO), Ag(BTCO), Ag(MCO) and Ag(PiPCO). The compounds exhibit a remarkable resistance to high intensity visible light, UV radiation and heat and have poor solubility in water. All these compounds can be well incorporated into the light-curable acrylate polymeric composites that are currently used as dental fillers or adhesives of indwelling medical devices. A range of dry weight % from 0.5 to 5.0 of the compounds was tested in this study. To study the potential of these compounds in preventing planktonic and biofilm growth of bacteria, we selected two human pathogens (Gram-negative Pseudomonas aeruginosa and Gram-positive Staphylococcus aureus) and Gram-positive environmental isolate Bacillus aryabhattai. Both planktonic and biofilm growth was abolished completely in the presence of 0.5% to 5% of the compounds. The most efficient inhibition was shown by Ag(PiCO), Ag(BIHCO) and Ag(BTCO). The inhibition of biofilm growth by Ag(PiCO)-yellow was confirmed by scanning electron microscopy (SEM). Application of Ag(BTCO) and Ag(PiCO)-red in combination with tobramycin, the antibiotic commonly used to treat P. aeruginosa infections, showed a significant synergistic effect. Finally, the inhibitory effect lasted for at least 120 h in P. aeruginosa and 36 h in S. aureus and B. aryabhattai. Overall, several silver(I) cyanoximates complexes efficiently prevent biofilm development of both Gram-negative and Gram-positive bacteria and present a particularly significant potential for applications against P. aeruginosa infections.

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“…However, there are a few theories that explain why SNPs are antibacterial: (A) the release of Ag + ions from SNPs denaturizes proteins by interacting with sulfhydryl groups; (B) the adhesion of SNPs to bacteria and the subsequent damage to bacteria's capacity to live; (C) the attachment of SNPs to bacteria and the subsequent damage to bacteria's ability to survive (this results in high Ag + concentrations near the bacterial cell wall over time, inhibiting bacterial growth). However, a recent study has found that Ag + generated by SNPs may be antibacterial, resulting in cell damage or repercussions [47,48]. Positive silver ions interact with the negative cell membrane, causing morphological damage to the cell and subsequent cell leakage, which leads to cell death [49].…”

Section: Discussionmentioning

confidence: 99%

Application of Biosynthesized Silver Nanoparticles from Oak Fruit Exudates against Pectobacterium carotovorum subsp. carotovorum Causing Postharvest Soft Rot Disease in Vegetables

et al. 2023

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The main goal of our study was to determine whether biosynthesized silver nanoparticles (SNPs) could be used as a novel antibacterial material in order to control soft rot in vegetables. Exudates from oak fruit were used in the green synthesis of SNPs. Postharvest soft rot disease in vegetables has resulted in significant crop losses all over the globe. Because managing Pectobacterium carotovorum subsp. carotovorum (Pcc), the causal agent of soft rot disease, is difficult due to its wide host range, developing innovative disease-management methods that do not involve the use of hazardous chemicals is a top priority for maintaining sustainable agriculture. The current research has found that silver nanoparticles (SNPs) have a detrimental effect on the progression of Pcc and soft rot disease in in vitro conditions. At SNPs’ sub-MIC, the greatest levels of inhibition against tissue maceration were 22, 19.8, 21.5, and 18.5 percent in potato, zucchini, carrot, and eggplant, respectively. SNP treatment of tubers and fruits had a noteworthy suppressive impact on soft rot disease symptoms as compared to controls. SNPs may be able to replace chemical pesticides in the management and prevention of soft rot disease in vegetables in postharvest settings, according to this study.

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Enhanced antibacterial effect of azlocillin in conjugation with silver nanoparticles against Pseudomonas aeruginosa

Cited by 13 publications

References 17 publications

Silver Nanoparticles and Their Antibacterial Applications

Silver Nanoparticles and Their Antibacterial Applications

Polymeric Composites with Silver (I) Cyanoximates Inhibit Biofilm Formation of Gram-Positive and Gram-Negative Bacteria

Application of Biosynthesized Silver Nanoparticles from Oak Fruit Exudates against Pectobacterium carotovorum subsp. carotovorum Causing Postharvest Soft Rot Disease in Vegetables

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