Combined use of modulated ultrasound and electric current stimulation for diabetic foot ulcers: a case series

O’Connor, Tom; Moore, Zena; Patton, Declan; Wilson, Pauline; Gillen, C.; Hughes, Michael; Reilly, Aoife

doi:10.12968/jowc.2017.26.11.632

Cited by 3 publications

(1 citation statement)

References 23 publications

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“…Electrical stimulation has also been used to treat pressure ulcer healing in spinal cord patients, [ 157 ] and combinations of ultrasound and electric current stimulation used to treat diabetic foot ulcers. [ 158 ] Neuromuscular electro‐stimulation of lower limb wounds and electro‐stimulation of chronic wounds have also been employed in an attempt to stimulate healing. [ 159 ]…”

Section: Electro‐stimulation and Tissue Repairmentioning

confidence: 99%

Electro‐Stimulation, a Promising Therapeutic Treatment Modality for Tissue Repair: Emerging Roles of Sulfated Glycosaminoglycans as Electro‐Regulatory Mediators of Intrinsic Repair Processes

Hayes

Melrose

2020

Advanced Therapeutics

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Glycosaminoglycans (GAGs) are a family of diverse biomolecules that decorate proteoglycans in the glycocalyx and extracellular matrix of all cells. They exist as linear polysaccharide chains consisting of repeating disaccharide units that can be variably sulfated and carboxylated along their GAG chain length. These ionizable carboxyl and sulfate groups on GAGs create charged interactive motifs that convey cell regulatory properties important in tissue homeostasis and the maintenance of optimal tissue function. GAGs participate in a number of essential physiological processes including coagulation‐fibrinolysis, matrix assembly and stabilization, immune regulation, and the complement system. The high fixed charge density and the counter‐ions of GAGs is central to their role in the hydration of various connective tissues within the body. Charge transfer properties of GAGs make them amenable to electro‐stimulation and offers a potential mechanism for promoting or enhancing cellular tissue repair processes. This review is undertaken to illustrate these properties and to gain a better understanding of how these processes might be manipulated through electro‐stimulation to help improve tissue repair and the recovery of normal function in traumatized tissues. Weight‐bearing and tension‐bearing, collagen‐rich, avascular tissues have intrinsically poor repair properties and represent difficult clinical challenges. Electro‐stimulation represents a novel approach with significant potential in the stimulation of repair in these most intransigent of tissues.

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Section: Electro‐stimulation and Tissue Repairmentioning

confidence: 99%

Electro‐Stimulation, a Promising Therapeutic Treatment Modality for Tissue Repair: Emerging Roles of Sulfated Glycosaminoglycans as Electro‐Regulatory Mediators of Intrinsic Repair Processes

Hayes

Melrose

2020

Advanced Therapeutics

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Piezoelectric and photothermal dual functional film for enhanced dermal wound regeneration via upregulation of Hsp90 and HIF-1α

Chen

Song

et al. 2020

Applied Materials Today

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Effectiveness of combined modulated ultrasound and electric current stimulation to treat diabetic foot ulcers

et al. 2022

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Objective: The use of combined ultrasound and electrostimulation (CUSECS) as an adjunct therapy for diabetic foot ulcers (DFUs) is a relatively new concept. This study aimed to investigate if combined ultrasound and electrostimulation is an effective adjunctive treatment for hard-to-heal DFUs when compared with standard wound care. Methods: A randomised controlled pilot study design was used. Patients with hard-to-heal DFUs from two centres were sequentially randomised. For 8 weeks, the experimental group received CUSECS and standard wound care treatment twice a week. The control group received standard wound care treatment once a week. Wound changes were documented using photography, which also facilitated wound size measurement. Self-efficacy, economic cost, quality of life and reoccurrence rates were analysed as secondary objectives. Results: The experimental group (n=6) achieved a higher rate of mean wound healing (mean difference (MD): 0.49) when compared to the control group (n=5, MD: 0.01). Two participants completed full healing in the experimental group and one in the control group. There were no statistically significant findings because of the small sample size. There were no direct adverse reactions to this therapy. Quality of life scores improved in the treatment group. There was no significant change in self-efficacy scores. Costs were higher in the experimental group; however, the healing rate was quicker, which could be extrapolated to cost reductions over time. Conclusion: Results suggest that CUSECS may be a useful adjunctive therapy for treatment of hard-to-heal DFUs. Further large-scale studies are needed to ascertain the effectiveness of CUSECS. The findings here are inconclusive but indicate that CUSECS may offer promise as a treatment.

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Combined use of modulated ultrasound and electric current stimulation for diabetic foot ulcers: a case series

Abstract: The results of this small case series indicate that combined modulated ultrasound and electric current stimulation offers promise as an adjunct therapy for DFUs. Further large scale trials are now warranted.

Cited by 3 publications

References 23 publications

Electro‐Stimulation, a Promising Therapeutic Treatment Modality for Tissue Repair: Emerging Roles of Sulfated Glycosaminoglycans as Electro‐Regulatory Mediators of Intrinsic Repair Processes

Electro‐Stimulation, a Promising Therapeutic Treatment Modality for Tissue Repair: Emerging Roles of Sulfated Glycosaminoglycans as Electro‐Regulatory Mediators of Intrinsic Repair Processes

Piezoelectric and photothermal dual functional film for enhanced dermal wound regeneration via upregulation of Hsp90 and HIF-1α

Effectiveness of combined modulated ultrasound and electric current stimulation to treat diabetic foot ulcers

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