2017
DOI: 10.17116/jnevro20171179115-20
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Abstract: RBD in patients with PD is associated with the rapid progress of nocturia, higher degree of worsening of daily activities and deterioration of quality of life. The relationship between RBD and progression of nighttime urination suggests common pathophysiological mechanisms of their development, which include the structural changes in the brain stem nuclei. The diagnosis of RBD is one of the markers of spreading of neurodegenerative pathology into the brain stem that resulted in the unfavorable disease course.

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Cited by 4 publications
(1 citation statement)
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“…There are data on the variability of changes in the stages of slow-wave sleep (NREM) and the duration of the phase of paradoxical sleep (REM) [14]. It has been shown that changes in the wake-sleep cycle in PD are caused, in particular, by an imbalance of neurotransmitters in the monoaminergic and cholinergic systems of the brain due to degeneration of the brainstem nuclei and structural and functional disorders in the system of descending connections of hypothalamic neurons with dopaminergic neurons of the ventral tegmentum, as well as ascending stem-thalamo-cortical projections [15,16], which may indicate the endogenous nature of the causes of sleep disorders. Its unsatisfactory quality is one of the leading factors that worsen the quality of life of patients with early and advanced stages of PD, which in 40−50 % of cases are not diagnosed and not subjected to appropriate correction [17][18][19][20][21][22].…”
Section: Introductionmentioning
confidence: 99%
“…There are data on the variability of changes in the stages of slow-wave sleep (NREM) and the duration of the phase of paradoxical sleep (REM) [14]. It has been shown that changes in the wake-sleep cycle in PD are caused, in particular, by an imbalance of neurotransmitters in the monoaminergic and cholinergic systems of the brain due to degeneration of the brainstem nuclei and structural and functional disorders in the system of descending connections of hypothalamic neurons with dopaminergic neurons of the ventral tegmentum, as well as ascending stem-thalamo-cortical projections [15,16], which may indicate the endogenous nature of the causes of sleep disorders. Its unsatisfactory quality is one of the leading factors that worsen the quality of life of patients with early and advanced stages of PD, which in 40−50 % of cases are not diagnosed and not subjected to appropriate correction [17][18][19][20][21][22].…”
Section: Introductionmentioning
confidence: 99%