Titrated extract of<i>Centella asiatica</i>increases hair inductive property through inhibition of STAT signaling pathway in three-dimensional spheroid cultured human dermal papilla cells

Choi, Youngkeun; An, Sungkwan; Lee, Junwoo; Lee, Jae Ho; Lee, Jae Nam; Kim, Young Sam; Ahn, Kyu Joong; An, In‐Sook; Bae, Seunghee

doi:10.1080/09168451.2017.1385383

Cited by 16 publications

(18 citation statements)

References 51 publications

(75 reference statements)

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“…(Ling et al, 2017). Lastly, C. asiatica also demonstrated a positive activation effect on dermal papilla, improved the viability of dermal papilla cells and increased the expression of characteristic genes related to hair growth in the cells, thus providing good application prospects for baldness (Choi et al, 2017).…”

Section: Effects On Skin Diseasesmentioning

confidence: 94%

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Therapeutic Potential of Centella asiatica and Its Triterpenes: A Review

Sun

et al. 2020

Front. Pharmacol.

142

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Centella asiatica (also known as Centella asiatica (L.) Urb. or Gotu kola) is a traditional Chinese medicine with extensive medicinal value, which is commonly used in Southeast Asian countries. This study aimed to summarize the effects of C. asiatica and its main components on neurological diseases, endocrine diseases, skin diseases, cardiovascular diseases, gastrointestinal diseases, immune diseases, and gynecological diseases, as well as potential molecular mechanisms, to study the pathological mechanism of these diseases based on the changes at the molecular level. The results showed that C. asiatica and its triterpenoids had extensive beneficial effects on neurological and skin diseases, which were confirmed through clinical studies. They exhibited anti-inflammatory, antioxidative stress, anti-apoptotic effects, and improvement in mitochondrial function. However, further clinical studies are urgently required due to the low level of evidence and lack of patients.

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Section: Effects On Skin Diseasesmentioning

confidence: 94%

“…The C. asiatica extract and its triterpenoids had certain therapeutic and relieving effects on acne, baldness, vitiligo, atopic dermatitis, and wounds (Sawatdee et al, 2016;Choi et al, 2017;Ling et al, 2017;Ju Ho et al, 2018;Shen et al, 2019) (Table 4).…”

Section: Effects On Skin Diseasesmentioning

confidence: 99%

Therapeutic Potential of Centella asiatica and Its Triterpenes: A Review

Sun

et al. 2020

Front. Pharmacol.

142

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“…The research on herbs and active constituents as hair growth promoters has been driven by their less toxicity, easy availability, low‐cost, patient compliance and more than one mode of biochemical action . Specific effects of herbal extracts, polyherbal formulations, flavonoids and natural compounds on DPCs have been examined . In vivo hair growth promoting effects as proof of concept are also mentioned.…”

Section: Hair Growth Promoting Effectmentioning

confidence: 99%

Review of Hair Follicle Dermal Papilla cells as in vitro screening model for hair growth

Madaan

Verma

Singh

et al. 2018

Intern J of Cosmetic Sci

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Hair disorders such as hair loss (alopecia) and androgen dependent, excessive hair growth (hirsutism, hypertrichosis) may impact the social and psychological well-being of an individual. Recent advances in understanding the biology of hair have accelerated the research and development of novel therapeutic and cosmetic hair growth agents. Preclinical models aid in dermocosmetic efficacy testing and claim substantiation of hair growth modulators. The in vitro models to investigate hair growth utilize the hair follicle Dermal Papilla cells (DPCs), specialized mesenchymal cells located at the base of hair follicle that play essential roles in hair follicular morphogenesis and postnatal hair growth cycles. In this review, we have compiled and discussed the extensively reported literature citing DPCs as in vitro model to study hair growth promoting and inhibitory effects. A variety of agents such as herbal and natural extracts, growth factors and cytokines, platelet-rich plasma, placental extract, stem cells and conditioned medium, peptides, hormones, lipid-nanocarrier, light, electrical and electromagnetic field stimulation, androgens and their analogs, stress-serum and chemotherapeutic agents etc. have been examined for their hair growth modulating effects in DPCs. Effects on DPCs' activity were determined from untreated (basal) or stress induced levels. Cell proliferation, apoptosis and secretion of growth factors were included as primary end-point markers. Effects on a wide range of biomolecules and mechanistic pathways that play key role in the biology of hair growth were also investigated. This consolidated and comprehensive review summarizes the up-to-date information and understanding regarding DPCs based screening models for hair growth and may be helpful for researchers to select the appropriate assay system and biomarkers. This review highlights the pivotal role of DPCs in the forefront of hair research as screening platforms by providing insights into mechanistic action at cellular level, which may further direct the development of novel hair growth modulators.

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“…We observed that DPS-1 increased the viability and spheroid formation of 3D cultured HDP. Indeed, recent studies have shown that hair inductivity of HDP cells are markedly improved in 3D spheroid formation rather than 2D culture (Choi et al 2017). Therefore, promoting HDP inductivity by DPS-1 may contribute to establish protocol for HF generation in vitro.…”

Section: Discussionmentioning

confidence: 99%

“…Previous studies showed that WNT/β-catenin and TGFβ family interact to regulate the transcription of a number of genes, which is related with HF formation. Furthermore, there are synergistic effects between WNT/β-catenin and TGFβ signaling pathway in various cellular functions including tumorigenesis and stem cell differentiation (Choi et al 2017). Because TGFβ family is crucial for HF morphogenesis as well as hair cycle, we developed synthetic peptides which are structurally similar to endogenous human TGFβ family but possess unique sequences, which we named, dermal papilla stem cell activator-1 (DPS-1).…”

Section: Introductionmentioning

confidence: 99%

TGFβ family mimetic peptide promotes proliferation of human hair follicle dermal papilla cells and hair growth in C57BL/6 mice

Choi¹,

Choi²,

Kim³

et al. 2018

biomed dermatol

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Background: Hair follicle morphogenesis is orchestrated by bidirectional ectodermal-mesenchymal signaling. In particular, TGFβ (transforming growth factor-beta) family is an important regulator of hair follicle formation and cycling. In this study, we investigated the effect of TGFβ family mimetic peptide (dermal papilla stem cell activator-1, DPS-1) on activation of hair follicle formation. Methods: Cell viability, cell cycle, and mRNA expression of human dermal papilla (HDP) cells after DPS-1 or vehicle treatment were determined, and histological analysis of hair cycle was performed from the mouse dorsal back skin after DPS-1 or vehicle administration. Results: DPS-1 promotes proliferation from 3D sphered HDP cells, but not from 2D cultured HDP cells. DPS-1 induces mRNA expression of genes, which are responsible for hair growth from HDP cells. Moreover, topical administrated DPS-1 stimulates hair growth in mice. Subsequently, histological analysis showed that the diameter and depth of hair follicles were remarkably higher in mice that were administered with DPS-1 compared to vehicle control. Conclusions: DPS-1 promotes proliferation of HDP cells as well as hair growth partly via activation of WNT/β-catenin signaling.

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Titrated extract ofCentella asiaticaincreases hair inductive property through inhibition of STAT signaling pathway in three-dimensional spheroid cultured human dermal papilla cells

Cited by 16 publications

References 51 publications

Therapeutic Potential of Centella asiatica and Its Triterpenes: A Review

Therapeutic Potential of Centella asiatica and Its Triterpenes: A Review

Review of Hair Follicle Dermal Papilla cells as in vitro screening model for hair growth

TGFβ family mimetic peptide promotes proliferation of human hair follicle dermal papilla cells and hair growth in C57BL/6 mice

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