2017
DOI: 10.3945/an.117.015818
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Abstract: Limited evidence exists to support the withholding of feeds during packed red blood cell (PRBC) transfusion to reduce the incidence of transfusion-associated necrotizing enterocolitis (TANEC) in preterm infants. The aim of the manuscript was to systematically review studies reporting the effect of implementing a policy of withholding feeds on the incidence of TANEC in preterm infants. The following databases were searched for relevant studies published between the databases' inception and December 2016: PubMed… Show more

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Cited by 34 publications
(28 citation statements)
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“…Studies have shown that continuation of enteral feed during RBC transfusion blunts post‐prandial mesenteric hyperaemia for up to 48 h after transfusion (Marin et al , ). A 2017 systematic review of 7 non‐randomised trials ( n = 7,492) concluded that withholding feed during RBC transfusion may reduce the incidence of TA‐NEC (risk ratio 0·47, P = 0·005), leading to many centres adopting the practice of withholding feeds during RBC transfusions in high risk infants (Jasani et al , ). In stark contrast, however, a 2018 meta‐analysis of 13 observational studies ( n = 15,675) demonstrated a potentially protective effect of RBC transfusions on the subsequent development NEC (unadjusted odds ratio = 0·55, 95% CI 0·31–0·98) (Rai et al , ).…”
Section: When Do We Give Rbc Transfusions For Anaemia Of Prematurity?mentioning
confidence: 99%
“…Studies have shown that continuation of enteral feed during RBC transfusion blunts post‐prandial mesenteric hyperaemia for up to 48 h after transfusion (Marin et al , ). A 2017 systematic review of 7 non‐randomised trials ( n = 7,492) concluded that withholding feed during RBC transfusion may reduce the incidence of TA‐NEC (risk ratio 0·47, P = 0·005), leading to many centres adopting the practice of withholding feeds during RBC transfusions in high risk infants (Jasani et al , ). In stark contrast, however, a 2018 meta‐analysis of 13 observational studies ( n = 15,675) demonstrated a potentially protective effect of RBC transfusions on the subsequent development NEC (unadjusted odds ratio = 0·55, 95% CI 0·31–0·98) (Rai et al , ).…”
Section: When Do We Give Rbc Transfusions For Anaemia Of Prematurity?mentioning
confidence: 99%
“…A previous review suggested that fasting during transfusion significantly decreased the incidence of transfusion-related NEC, 16 while not transfusion, but severe anemia was reported to be associated with the increase in the risk of NEC in VLBW infants. 17 Although no consistent conclusions have been reached, our survey showed that fasting is avoided in many facilities.…”
Section: Discussionmentioning
confidence: 69%
“…Since then, many researchers have been published their studies about this issue, such as a recent meta-analysis in 7 non-randomized clinical trials (RCT), that showed withholding the nutrition in peri-transfusion periods reduces the rate of NEC. Regard to the moderate quality of this research, they suggest adequately powered RCT for better results (8).…”
Section: Introductionmentioning
confidence: 91%