Effect of tranexamic acid on gross hematuria: A pilot randomized clinical trial study

Moharamzadeh, Payman; Ojaghihaghighi, Seyedhossein; Amjadi, Mohsen; Rahmani, Farzad; Farjamnia, Arezoo

doi:10.1016/j.ajem.2017.09.012

Cited by 27 publications

(13 citation statements)

References 8 publications

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“…It found a decreased time on C.B.I. until resolution of hematuria, however no significant difference in blood loss or transfusions rates were noticed in the treatment group (Moharamzadeh, Ojaghihaghighi, Amjadi, Rahmani, & Farjamnia, 2017). While further studies may demonstrate a benefit in treatment of patients with RHC with tranexamic acid at this time there is insufficient published data to support this.…”

Section: Goucher Et Al Bpr: Radiation-induced Hemorrhagic Cystitismentioning

confidence: 87%

Canadian Urological Association Best Practice Report: Diagnosis and management of radiation-induced hemorrhagic cystitis

Goucher¹,

Saad²,

Lukka³

et al. 2018

CUAJ

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Section: Goucher Et Al Bpr: Radiation-induced Hemorrhagic Cystitismentioning

confidence: 87%

Canadian Urological Association Best Practice Report: Diagnosis and management of radiation-induced hemorrhagic cystitis

Goucher¹,

Saad²,

Lukka³

et al. 2018

CUAJ

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“…In the ED, topical TXA has primarily been used for cases of epistaxis [7]. There is a newly emerging body of ED literature that has found successful use of TXA in trials for treatment of epistaxis [8,9] and urinary tract bleeding [10].…”

Section: Discussionmentioning

confidence: 99%

Topical use of tranexamic acid for the management of post-procedural rectal bleeding

Altawil

Gendron

Schechter‐Perkins

2019

The American Journal of Emergency Medicine

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“…The authors found reduced bladder irrigate requirements (9.52 ± 4.13 L in the tranexamic group vs 12.00 ± 4.22 L in the placebo group; P = .04) and a faster time to resolution of microscopic hematuria in the TXA group (P = .026). 50…”

Section: Hematuriamentioning

confidence: 99%

The Role of Tranexamic Acid in the Management of an Acutely Hemorrhaging Patient

et al. 2020

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Background: Acute hemorrhage, both traumatic and nontraumatic, leads to significant morbidity and mortality, both in the United States and globally. Traditional treatment of acute hemorrhage is focused on hemostasis and blood product replacement. Tranexamic acid is an antifibrinolytic agent that may reduce acute hemorrhage through inhibition of plasminogen. Newer research suggests that coagulopathy, specifically fibrinolysis, may contribute significantly to the pathology of acute hemorrhage. Methods: We searched the PubMed database for relevant articles from 2000 to 2018 for the terms “tranexamic acid,” “TXA,” “antifibrinolytic,” “hyperfibrinolysis,” and “coagulopathy.” Our search was limited to studies published in the English language. Results: A total of 53 studies were included in this review. These articles suggest a potential role for tranexamic acid in the management of acute intracranial hemorrhage, epistaxis, hematuria, postpartum hemorrhage, gastrointestinal hemorrhage, and trauma-related hemorrhage. A theoretical risk of thrombotic events following tranexamic acid use exists, though large clinical trials suggest this risk remains exceedingly small. Conclusions: Recent studies suggest a mortality benefit with tranexamic acid following acute hemorrhage. First responders such as emergency medical technicians and emergency department clinicians should consider tranexamic acid as an adjunct therapy in the management of acute, severe traumatic and nontraumatic hemorrhage.

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Effect of tranexamic acid on gross hematuria: A pilot randomized clinical trial study

Cited by 27 publications

References 8 publications

Canadian Urological Association Best Practice Report: Diagnosis and management of radiation-induced hemorrhagic cystitis

Canadian Urological Association Best Practice Report: Diagnosis and management of radiation-induced hemorrhagic cystitis

Topical use of tranexamic acid for the management of post-procedural rectal bleeding

The Role of Tranexamic Acid in the Management of an Acutely Hemorrhaging Patient

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