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Cited by 87 publications
(53 citation statements)
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References 18 publications
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“…This is also in line with the iTACTIC protocol [167]. In severe traumatic hemorrhage, fixed-ratio RBC and plasma transfusion is not effective to treat ATC and to reduce mortality [12][13][14][15][16][17]171]. Innerhofer et al compared in their RCT the efficacy of ROTEM-guided administration of coagulation factor concentrates (fibrinogen, factor XIII, and four-factor PCC) versus plasma transfusion to treat ACT and to stop bleeding [172,173].…”
Section: In Trauma and Orthopedic Surgerymentioning
confidence: 78%
See 1 more Smart Citation
“…This is also in line with the iTACTIC protocol [167]. In severe traumatic hemorrhage, fixed-ratio RBC and plasma transfusion is not effective to treat ATC and to reduce mortality [12][13][14][15][16][17]171]. Innerhofer et al compared in their RCT the efficacy of ROTEM-guided administration of coagulation factor concentrates (fibrinogen, factor XIII, and four-factor PCC) versus plasma transfusion to treat ACT and to stop bleeding [172,173].…”
Section: In Trauma and Orthopedic Surgerymentioning
confidence: 78%
“…Ratio-based transfusion concepts do not correct coagulopathy and do not reduce mortality in patients with severe hemorrhage [13][14][15][16][17]. Ratio-based concepts do not stop bleeding.…”
Section: Introductionmentioning
confidence: 99%
“…23 Conversely, a separate systematic review concluded that there was insufficient evidence to administer a high ratio of platelets and plasma to bleeding trauma patients, given the limited observed clinical benefits. 24 In summary, there are conflicting conclusions, reflecting a lack of high-quality, randomized trial data on the isolated effect of platelet transfusions on outcomes in bleeding trauma patients.…”
Section: Introductionmentioning
confidence: 99%
“…In a systematic review of optimal dose, timing and ratio of blood products for MT, McQuilten et al . () identified six completed RCTs and concluded that, for adult patients with critical bleeding from any cause, there is insufficient evidence to recommend a 1 : 1 : 1 plasma to RBC ratio over a 1 : 1 : 2 ratio or standard care. Of the six studies, five were performed in an adult trauma population and found no evidence of a mortality or morbidity benefit of using higher ratios.…”
Section: Blood Component and Coagulation Factor Supportmentioning
confidence: 99%
“…Prior to 2006, formalised MTPs were uncommon but have been widely adopted in the last decade (Callum et al, ). Many guidelines have been released, but these are often limited in their ability to make recommendations because of uncertainty surrounding which patient populations benefit from MTs and how best to approach therapy for different settings as trials are difficult to conduct, and there are fewer data from prospective studies (McQuilten et al, ). MTPs have now been developed for most critically bleeding patient populations (National Blood Authority, , ) even though the most studied population is trauma, and the benefit of some aspects of these guidelines to other non‐trauma patient populations is less certain.…”
mentioning
confidence: 99%