Red blood cell membrane-camouflaged melanin nanoparticles for enhanced photothermal therapy

Designing Bioinspired 2D MoSe2 Nanosheet for Efficient Photothermal‐Triggered Cancer Immunotherapy with Reprogramming Tumor‐Associated Macrophages

“…Interestingly, the tumor volume from CS–MoSe 2 nanosheet with NIR group kept around 0.1 cm 3 at the first ten days, however, starting from day 12, the tumor volume increased sharply, which may be due to the capture of CS–MoSe 2 nanosheet by macrophages, leading to curative effect decline during the NIR treatment. Moreover, as shown in Figure E and Figure S10 in the Supporting Information, it could be noticed obviously that group of RBC–MoSe 2 combined with laser exhibited the most effective photothermal therapy with the lowest relative tumor growth ratio (4.74%), and compared to the PTT efficacy of RBC decorated melanin nanoparticles or other RBC decorated nanoparticles with high dosage, RBC–MoSe 2 exhibited better PTT efficacy owing to its higher photothermal conversion efficiency with dosage only at 1.25 mg kg −1 , which is a curial parameter to evaluate the side effects and toxicity of nanomaterials to human bodies . After PTT treatment for 21 days, MRI was used to analyze the physiological condition of nude mice treated with PTT profoundly, as shown in Figure F and Figure S11 in the Supporting Information, the tumor volume from group of RBC–MoSe 2 with laser was the smallest since the gray signal decreased intensively.…”

Biomimetic Synthesis of Ag2Se Quantum Dots with Enhanced Photothermal Properties and as “Gatekeepers” to Cap Mesoporous Silica Nanoparticles for Chemo–Photothermal Therapy

“…[9] However, most PTT agentsa re difficult to be degraded in the body, which makes them hard to be authorized by FDA( U.S. Food and Drug Administration). [10] In another way,m any efforts have been devoted to research the toxicity of Ag 2 Se QDs in vivo. [11] The results showedt hat the Ag 2 Se QDs exhibited lowt oxicity even if the injection amount of Ag 2 Se QDs in mice was as high as 8 mmol kg À1 ,b ecause the Ag 2 Se QDs were significantly converted to Ag and Se and could be rapidlye liminated from the blood.…”

A Yolk–Shell Nanoplatform for Gene‐Silencing‐Enhanced Photolytic Ablation of Cancer

“…Insufficient enrichment of nanoparticles at tumor region will greatly decrease the therapeutic effects of nanoagents . Hence, the PEG chains and Tf molecules are conjugated on the surface of PPy@mSiO 2 following procedures we previously published, to endow the particles with long term circulation time and specific cancer targeting ability .…”