2017
DOI: 10.1182/blood-2017-01-759258
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Abstract: The effect of variation in platelet function in platelet donors on patient outcome following platelet transfusion is unknown. This trial assessed the hypothesis that platelets collected from donors with highly responsive platelets to agonists in vitro assessed by flow cytometry (high-responder donors) are cleared more quickly from the circulation than those from low-responder donors, resulting in lower platelet count increments following transfusion. This parallel group, semirandomized double-blinded trial was… Show more

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Cited by 22 publications
(19 citation statements)
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“…28 The differences in these findings may be related to heterogeneity among the recipients or the PLT donors. 29 Fewer studies have been published that explore a similar association in children. Given the differences in physiology and etiologies of critical illness that exist between children and adults, pediatric patients may have different clinical outcomes associated with the storage age of the PLT concentrates.…”
Section: Discussionmentioning
confidence: 99%
“…28 The differences in these findings may be related to heterogeneity among the recipients or the PLT donors. 29 Fewer studies have been published that explore a similar association in children. Given the differences in physiology and etiologies of critical illness that exist between children and adults, pediatric patients may have different clinical outcomes associated with the storage age of the PLT concentrates.…”
Section: Discussionmentioning
confidence: 99%
“…[32, 38, 39] Moreover, recent work by Kelly et al ., showed that the ability of platelet apheresis units to increase platelet count in non-bleeding cancer patients with thrombocytopenia was independent of the degree of platelet function as measured by aggregometry, P-selectin expression and fibrinogen binding. [40] Thus, perhaps as long as patients have a threshold concentration of functional platelets in circulation, the transfusion of additional platelets, even though they may exhibit reduced absolute activity, may be sufficient to stop bleeding. In this setting, the reactivity of the platelets within platelet apheresis units may be secondary to the ability to rapidly transport platelet apheresis units to patients at risk of hemorrhage.…”
Section: Discussionmentioning
confidence: 99%
“…Unfortunately, no model accurately predicts the interplay between donor and patient platelets or the hemostatic effects of transfused platelets [50,51]. A recent study found that transfused platelets are not cleared from the bloodstream dependent on the platelet function in vitro [52]. While this area remains to be fully studied due to methodological limitations of platelet aggregation tests during thrombocytopenia, it would be very relevant for the interpretation of recent studies of bleeding in thrombocytopenia.…”
Section: Why Do Patients With Hematological Disease Have Impaired Plamentioning
confidence: 99%