2017
DOI: 10.1097/ta.0000000000001531
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Abstract: BACKGROUND ACS-TQIP Best Practices recommends initial massive transfusion (MT) cooler delivery within 15 minutes of protocol activation, with a goal of 10 minutes. The current study sought to examine the impact of timing of first cooler delivery on patient outcomes. METHODS Patients predicted to receive MT at 12 level-1 trauma centers were randomized to two separate transfusion ratios as described in the PROPPR trial. ABC score or clinician gestalt prediction of MT was used to randomize patients and call for… Show more

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Cited by 198 publications
(101 citation statements)
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“…Exsanguination is still the major cause of preventable mortality in trauma [ 6 ]. Haemorrhage control and haemostatic resuscitation are the cornerstones of in-hospital treatment, with delays in transfusion related to increased mortality [ 7 ].…”
Section: Discussionmentioning
confidence: 99%
“…Exsanguination is still the major cause of preventable mortality in trauma [ 6 ]. Haemorrhage control and haemostatic resuscitation are the cornerstones of in-hospital treatment, with delays in transfusion related to increased mortality [ 7 ].…”
Section: Discussionmentioning
confidence: 99%
“…In clinical trials that focus on emergency interventions, most patients are unresponsive or incapable of making informed consent decisions related to their treatment, and legally authorized representatives are often not immediately available to make decisions on their behalf. This has led to increasing use of exception from informed consent (EFIC) for such trials [3,4]. EFIC is a method of enrollment without consent in emergencies in which consent cannot be obtained.…”
Section: Introductionmentioning
confidence: 99%
“…Critical bleeding secondary to trauma occurs rapidly after injury [ 1 , 2 ] and remains a common cause of potentially avoidable deaths [ 3 ]. The Advanced Trauma Life Support (ATLS) class three and four shock represent life threatening conditions due to loss of 30% or more of circulating blood [ 4 ].…”
Section: Introductionmentioning
confidence: 99%
“…This approach should be considered in all patients with severe traumatic injuries who show severe hemorrhage, altered physiology, metabolic imbalance and thereby reduced physiologic reserve [ 9 ]. As a recent study demonstrated patient mortality increases by 5% for every minute that passes following MT protocol activation while awaiting initial transfusion [ 1 ].…”
Section: Introductionmentioning
confidence: 99%