Antitubercular activity of ZnO nanoparticles prepared by solution combustion synthesis using lemon juice as bio-fuel

Krishna, Prashanth Gopala; Ananthaswamy, Prashanth Paduvarahalli; Trivedi, Priyanka; Chaturvedi, Vinita; Mutta, Nagabhushana Bhangi; Ananda, S.; Erra, Amani; Yadavalli, Tejabhiram

doi:10.1016/j.msec.2017.02.093

Cited by 40 publications

(10 citation statements)

References 41 publications

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“…The study of Krishna et al (2016) demonstrated the high anticancer activity of ZnO nanoparticles against prostate and breast cancer cell lines. Krishna et al (2017) showed the anticancer activity of ZnO nanoparticles performed on two human cancer cell lines DU-145 (human prostate cell line) and Calu-6 (human pulmonary adenocarcinoma). Moreover, blood hemolysis studies conducted proved the bio compatibility of ZnO nanoparticles at varied concentrations.…”

Section: Resultsmentioning

confidence: 99%

Cytotoxic and antimicrobial effects of biosynthesized ZnO nanoparticles using of Chelidonium majus extract

Dobrucka

Długaszewska

Kaczmarek

2017

Biomed Microdevices

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The basic goal of this study was to synthesize zinc oxide nanoparticles using the Chelidonium majus extract and asses their cytotoxic and antimicrobial properties. The synthesized ZnO NPs were characterized by UV-Vis, Scanning Electron Microscopy (SEM) with EDS profile, Fourier Transform Infrared Spectroscopy (FTIR), X-ray diffraction (XRD), Transmission Electron Microscopy (TEM) and Atomic Force Microscopy (AFM). The aforementioned methods confirmed that the size of synthesized ZnO nanoparticles was at the range of 10 nm. The antimicrobial activity of ZnO nanoparticles synthesized using the Ch. majus extract was tested against standard strains of bacteria (Staphylococcus aureus NCTC 4163, Pseudomonas aeruginosa NCTC 6749, Escherichia coli ATCC 25922), yeast (Candida albicans ATCC 10231), filamentous fungi (molds: Aspergillus niger ATCC 16404, dermatophytes: Trichophyton rubrum ATCC 28188), clinical strains of bacteria (Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus) and yeast (Candida albicans). The study showed that zinc oxide nanoparticles were excellent antimicrobial agents. What is more, biologically synthesized ZnO nanoparticles demonstrate high efficiency in treatment of human non-small cell lung cancer A549.

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Section: Resultsmentioning

confidence: 99%

Cytotoxic and antimicrobial effects of biosynthesized ZnO nanoparticles using of Chelidonium majus extract

Dobrucka

Długaszewska

Kaczmarek

2017

Biomed Microdevices

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“…10 According to Food and Drug Administration (FDA), Zinc Oxide nanoparticles (ZnO NPs) have emerged as a promising potent development in the medical field, particularly in cancer applications, due to their minor toxicity to healthy human cells. 13,14 ZnO NPs exhibit in vivo protective activities in rats and mice, 15,16 suggesting their safety for mammalian tissues. At the same time, ZnO NPs demonstrate in vitro anticancer activities, 17 inciting cytotoxicity in a cell-specific and proliferation-dependent approach.…”

Section: Introductionmentioning

confidence: 99%

Antitumor and Radiosensitizing Effects of Zinc Oxide-Caffeic Acid Nanoparticles against Solid Ehrlich Carcinoma in Female Mice

et al. 2021

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This study aimed to evaluate the anticancer and radio-sensitizing efficacy of Zinc Oxide-Caffeic Acid Nanoparticles (ZnO-CA NPs). ZnO-CA NPs were formulated by the conjugation of Zinc Oxide nanoparticles (ZnO NPs) with caffeic acid (CA) that were characterized by Fourier Transform Infrared Spectra (FT-IR), X-ray Diffractometer (XRD), and Transmission Electron Microscopy (TEM). In vitro anticancer potential of ZnO-CA NPs was evaluated by assessing cell viability in the human breast (MCF-7) and hepatocellular (HepG2) carcinoma cell lines. In vivo anticancer and radio-sensitizing effects of ZnO-CA NPs in solid Ehrlich carcinoma-bearing mice (EC mice) were also assessed. Treatment of EC mice with ZnO-CA NPs resulted in a considerable decline in tumor size and weight, down-regulation of B-cell lymphoma 2 (BCL2) and nuclear factor kappa B (NF-κB) gene expressions, decreased vascular cell adhesion molecule 1 (VCAM-1) level, downregulation of phosphorylated-extracellular-regulated kinase 1 and 2 (p-ERK1/2) protein expression, DNA fragmentation and a recognizable peak at sub-G0/G1 indicating dead cells’ population in cancer tissues. Combined treatment of ZnO-CA NPs with γ-irradiation improved these effects. In conclusion: ZnO-CA NPs exhibit in-vitro as well as in-vivo antitumor activity, which is augmented by exposure of mice to γ-irradiation. Further explorations are warranted previous to clinical application of ZnO-CA NPs.

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“…Nanomedicines have higher stability and increased circulation time, and improve targeted cargo delivery thereby resulting in enhanced efficacy while limiting drug toxicity (1). Numerous types of nanoparticles, including alginate (2), PLGA (3, 4, 5, 6, 7, 8), silver (9, 10), silver and zinc (11, 12), polymeric (13), gallium (III) (14), chitosan (15, 16), lipid (17), and silica (18) have been reported as drug delivery vehicles for therapeutics that target infectious diseases. For example, acrylate nanoparticles increased the intracellular concentration of anti-tuberculosis chemotherapeutics to macrophages compared to free drugs (19).…”

Section: Introductionmentioning

confidence: 99%

In vitro Pharmacokinetic Cell Culture System that Simulates Physiologic Drug and Nanoparticle Exposure to Macrophages

et al. 2019

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Purpose An in vitro dynamic pharmacokinetic (PK) cell culture system was developed to more precisely simulate physiologic nanoparticle/drug exposure. Methods A dynamic PK cell culture system was developed to more closely reflect physiologic nanoparticle/drug concentrations that are changing with time. Macrophages were cultured in standard static and PK cell culture systems with rifampin (RIF; 5 μg/ml) or β-glucan, chitosan coated, poly(lactic-co-glycolic) acid (GLU-CS-PLGA) nanoparticles (RIF equivalent 5 μg/ml) for 6 h. Intracellular RIF concentrations were measured by UPLC/MS. Antimicrobial activity against M. smegmatis was tested in both PK and static systems. Results The dynamic PK cell culture system mimics a one-compartment elimination pharmacokinetic profile to properly mimic in vivo extracellular exposure. GLU-CS-PLGA nanoparticles increased intracellular RIF concentration by 37% compared to free drug in the dynamic cell culture system. GLU-CS-PLGA nanoparticles decreased M. smegmatis colony forming units compared to free drug in the dynamic cell culture system. Conclusions The PK cell culture system developed herein enables more precise simulation of human PK exposure (i.e., drug dosing and drug elimination curves) based on previously obtained PK parameters.

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Antitubercular activity of ZnO nanoparticles prepared by solution combustion synthesis using lemon juice as bio-fuel

Cited by 40 publications

References 41 publications

Cytotoxic and antimicrobial effects of biosynthesized ZnO nanoparticles using of Chelidonium majus extract

Cytotoxic and antimicrobial effects of biosynthesized ZnO nanoparticles using of Chelidonium majus extract

Antitumor and Radiosensitizing Effects of Zinc Oxide-Caffeic Acid Nanoparticles against Solid Ehrlich Carcinoma in Female Mice

In vitro Pharmacokinetic Cell Culture System that Simulates Physiologic Drug and Nanoparticle Exposure to Macrophages

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