Hybrid gels by conjugation of hyaluronic acid with poly(itaconic anhydride-co-3,9-divinyl-2,4,8,10-tetraoxaspiro (5.5)undecane) copolymers

Chiriac, Aurica P.; Niţă, Loredana E.; Diaconu, Alina; Bercea, Maria; Tudorachi, Niță; Pamfil, Daniela; Mititelu-Tarțău, Liliana

doi:10.1016/j.ijbiomac.2017.01.116

Cited by 14 publications

(9 citation statements)

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“…The values of G’ are correlated with the network strength [ 35 , 36 , 37 ]. From Figure 5 and Figure 6 it can be observed that Lys content in the sample influences considerably the gel strength.…”

Section: Resultsmentioning

confidence: 99%

“…The morphological characterization of hydrogels by SEM analysis provides essential information on the size, shape and distribution of pores in their three-dimensional matrix [38]. The The values of G' are correlated with the network strength [35][36][37]. From Figures 5 and 6 it can be observed that Lys content in the sample influences considerably the gel strength.…”

Section: Sem Microscopymentioning

confidence: 99%

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New Physical Hydrogels Based on Co-Assembling of FMOC–Amino Acids

Croitoriu¹,

Niţă²,

Chiriac³

et al. 2021

Gels

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In the last years, physical hydrogels have been widely studied due to the characteristics of these structures, respectively the non-covalent interactions and the absence of other necessary components for the cross-linking processes. Low molecular weight gelators are a class of small molecules which form higher ordered structures through hydrogen bonding and π–π interactions. In this context it is known that the formation of hydrogels based on FMOC–amino acids is determined by the primary structures of amino acids and the secondary structure arrangement (alpha–helix or beta–sheet motifs). The present study aimed to obtain supramolecular gels through co-assembly phenomenon using FMOC–amino acids as low molecular weight gelators. The stability of the new structures was evaluated by the vial inversion test, while FTIR spectra put into evidence the interaction between the compounds. The gel-like structure is evidenced by viscoelastic parameters in oscillatory shear conditions. SEM microscopy was used to obtain the visual insight into the morphology of the physical hydrogel network while DLS measurements highlighted the sol-gel transition. The molecular arrangement of gels was determined by circular dichroism, fluorescence and UV-Vis spectroscopy.

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Section: Resultsmentioning

confidence: 99%

Section: Sem Microscopymentioning

confidence: 99%

New Physical Hydrogels Based on Co-Assembling of FMOC–Amino Acids

Croitoriu¹,

Niţă²,

Chiriac³

et al. 2021

Gels

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“…[53] study was reported a freeform reversible embedding of suspended hydrogels 3D bioprinting method for creating constructs populated with human neuroblastoma cells SK-N-BE ( 2 HA is a natural polysaccharide found in cartilages and connective tissues and widely used in medical applications due to its biodegradability, biocompatibility, nontoxicity, nonadhesivity, shear thinning properties, high water absorption capacity and non-immunogenicity [63,64]. It also has an important role in regulating cellular behaviours such as cell migration, angiogenesis, viability, and proliferation [65].…”

Section: Polymers and Polymer Composites Prepared For 3d (Bio)printingmentioning

confidence: 99%

Trends in 3D Printing Processes for Biomedical Field: Opportunities and Challenges

Ghilan¹,

Chiriac²,

Niţă³

et al. 2020

J Polym Environ

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119

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Additive manufacturing (AM) is considered the latest technology that creates breakthrough innovations and addresses complex medical problems. This is clearly demonstrated by the promising results obtained in regenerative medicine, diagnosis, implants, artificial tissues and organs. This paper provides a basic understanding of the fundamentals of 3D/4D printing along with bioprinting processes. We are briefly discussing about the main printing systems including stereolithography, inkjet 3D printing, extrusion, laser-assisted printing, selective laser melting and Poly-Jet printing. The basic requirements for the selection of successful inks based on polymers, polymer blends, and composites are described. Furthermore, the on-going transition from 3D to 4D printing is highlighted with emphasis on the newest applications in the medical area. Also, a glimpse into the future possibilities and benefits provided by machine learning in the additive manufacturing field is emphasized. Machine learning can improve printing efficiency by using generative design and testing in the pre-fabrication stage. Finally, important limitations and prospects are identified. Within the next few years, AM is set to become an important component in patient-specific medical technologies.

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“…In this context, it is obvious that a vast literature data concerning (nano)gels based on polysaccharide structures for biomedical applications is available . This review describes only certain common polysaccharides, namely gellan gum, heparin, chondroitin sulfate (ChS), carrageenan, guar gum, galactose, agarose structures, which represent an important part of this special class of natural polymers.…”

Section: Nanogel‐integrated Hydrogelmentioning

confidence: 99%

Advancement in the Biomedical Applications of the (Nano)gel Structures Based on Particular Polysaccharides

Chiriac¹,

Ghilan²,

Neamţu³

et al. 2019

Macromolecular Bioscience

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The ORCID identification number(s) for the author(s) of this article can be found under https://doi.org/10.1002/mabi.201900187. Nanogels (Nano)gels from macromolecular compounds-natural, synthetic, or a combination thereof, suitable crosslinkers-and conferred characteristicssuch as degradability, size, charge, amphiphilicity, responsiveness, and softness-are capable of responding to the challenges imposed by bioengineering applications. Polysaccharide-based gels have received particular attention in this field. This review addresses recent advancement in the use of (nano)gel structures prepared only from compounds based on gellan gum, heparin, chondroitin sulfate, carrageenan, guar gum, galactose, or agarose, which represent an important part of the special class of natural polymers, the polysaccharides. Also, future trends are taken into discussion regarding the (nano)gels' use in biomedical applications such as biomimetics, biosensors, artificial muscles, and chemical separations in relation with their ability to be used as a vehicle for various biomolecules due to their physicochemical properties, biocompatibility, and biodegradability.

show abstract

Hybrid gels by conjugation of hyaluronic acid with poly(itaconic anhydride-co-3,9-divinyl-2,4,8,10-tetraoxaspiro (5.5)undecane) copolymers

Cited by 14 publications

References 50 publications

New Physical Hydrogels Based on Co-Assembling of FMOC–Amino Acids

New Physical Hydrogels Based on Co-Assembling of FMOC–Amino Acids

Trends in 3D Printing Processes for Biomedical Field: Opportunities and Challenges

Advancement in the Biomedical Applications of the (Nano)gel Structures Based on Particular Polysaccharides

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