2016
DOI: 10.1007/s11739-016-1594-4
|View full text |Cite
|
Sign up to set email alerts
|

Abstract: The impact of red blood cell transfusion on outcomes in patients with acute coronary syndrome is controversial. Pubmed, EMBASE, and Cochrane Library were searched for studies of red blood cell transfusion and acute coronary syndrome that were published in any language, from January 1, 1966, to April 1, 2016. We analyzed 17 observational studies, of 2,525,550 subjects. We conducted a systematic review with meta-analysis of studies assessing the association between blood transfusion and the risk for all-cause mo… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1
1
1
1

Citation Types

2
2
0

Year Published

2017
2017
2022
2022

Publication Types

Select...
7
2

Relationship

0
9

Authors

Journals

citations
Cited by 14 publications
(4 citation statements)
references
References 37 publications
2
2
0
Order By: Relevance
“…Several retrospective studies have reported an association between red blood cell transfusion and an excess risk of mortality and cardiovascular events (re-infarction, heart failure, stroke). These results were confirmed by a recent meta-analysis [39], in which transfusion was associated with a non-significant reduction of mortality when Hb was less than 8.0 g/dL [OR 0.52 (0.25-1.06)], but was associated with increased mortality when Hb was greater than 10.0 g/dL (OR 3.34 (2.25-4.97). However, this meta-analysis was based on retrospective studies comprising a number of confounding factors (age, comorbidities, bleeding).…”
Section: Rationalesupporting
confidence: 61%
“…Several retrospective studies have reported an association between red blood cell transfusion and an excess risk of mortality and cardiovascular events (re-infarction, heart failure, stroke). These results were confirmed by a recent meta-analysis [39], in which transfusion was associated with a non-significant reduction of mortality when Hb was less than 8.0 g/dL [OR 0.52 (0.25-1.06)], but was associated with increased mortality when Hb was greater than 10.0 g/dL (OR 3.34 (2.25-4.97). However, this meta-analysis was based on retrospective studies comprising a number of confounding factors (age, comorbidities, bleeding).…”
Section: Rationalesupporting
confidence: 61%
“…A recent meta-analysis showed that RBCT in acute coronary syndrome patients has no negative effect on mortality and other outcomes if it is performed at Hb concentration below 80 d L − 1 [23]. In our study we found that median pre-RBCT Hb concentration in this disease category was the lowest among disease categories in our study, namely 64 (IQR 51− 81) g L − 1 .…”
Section: Pre-rbct Hb Concentration In Different Primary Diagnosessupporting
confidence: 45%
“…4,13,14 Likewise, a meta-analysis involving a similar subset of patients also depicted that transfusion was beneficial at Hb levels <8 g/dL, whereas it was harmful only when performed at Hb levels >10 g/dL. 6 In cardiac surgical patients, observational studies showed somewhat permissive threshold Hb values linked to detrimental outcome than in the setting of PCI, approximately 7-8 g/dL. [15][16][17] In support of these findings, a recent large, randomized controlled trial with an additive analysis of 6-month follow-up data depicted that a Hb threshold of critical level in patients undergoing OPCAB.…”
Section: Discussionmentioning
confidence: 96%