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Cited by 23 publications
(24 citation statements)
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References 93 publications
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“…There is an increasing interest in the use of protease‐modulating dressings; the activity of proteases is a known prognostic factor in wound healing . However, there is a lack of evidence of effectiveness of these biomarkers in VLU management …”
Section: Resultsmentioning
confidence: 99%
“…There is an increasing interest in the use of protease‐modulating dressings; the activity of proteases is a known prognostic factor in wound healing . However, there is a lack of evidence of effectiveness of these biomarkers in VLU management …”
Section: Resultsmentioning
confidence: 99%
“…In the past two decades, wound care has received a lot of attention from researchers. Many studies have aimed to investigate which interventions might be effective in promoting wound healing or preventing wounds (Atkinson & Cullum, ; Dumville, Owens, Crosbie, Peinemann, & Liu, ; Lavallée, Gray, Dumville, Russell, & Cullum, ; Norman et al., ; Westby, Norman, Dumville, Stubbs, & Cullum, ). However, less has been written about the basic nature of wounds and their prevalence (Cullum et al., ).…”
Section: Introductionmentioning
confidence: 99%
“…Chronic venous leg ulcers are wounds that cause substantial morbidity, disability, hospitalization, and even mortality among older adults [3,4]. New therapies are needed because prevalence rates for CVLUs are rising and standard topical therapies are often ineffective [7,8,43]. The high levels and expression of PMN-derived proteases in fluid and tissues biopsied from CVLUs [44][45][46]47], and the significantly higher levels of PMN-derived proteases found in chronic wounds compared with healing wounds [48][49][50] indicate that sustained high levels of PMNderived proteases are factors in healing delays.…”
Section: Discussionmentioning
confidence: 99%
“…However, even with compression therapy, the median time to complete healing of uncomplicated CVLUs is reported to be 12 weeks; older (> 6 months) and larger ulcers (> 20 cm 2 ) require significantly more time to heal [6]. Other data indicate that nearly 60% of CVLUs remain unhealed after 12 weeks of compression therapy and usually recur [7,8]. Thus, new therapies to augment compression bandaging and other standard topical therapies are needed to improve CVLU outcomes and help prevent recurrence [9].…”
Section: Introductionmentioning
confidence: 99%