Antibacterial and anticancer PDMS surface for mammalian cell growth using the Chinese herb extract paeonol(4-methoxy-2-hydroxyacetophenone)

Jiao, Jiajia; Sun, Lili; Guo, Zaiyu; Hou, Sen; Hołyst, Robert; Lü, Yun; Feng, Xisheng

doi:10.1038/srep38973

Cited by 27 publications

(11 citation statements)

References 32 publications

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“…At present, seven classes of compounds have been isolated from CM: phenols, monoterpenes, monoterpene glycosides, flavonoids, tannins, triterpenoids and others [9] [10] [11] [12]. Phenols and monoterpene glycosides are the predominant active ingredients [13] [14] [15] [16]. Nevertheless, the therapeutic properties of CM always correlate with its sources and geographical origins [17].…”

Section: Introductionmentioning

confidence: 99%

Study on the Multi-Component Quantitation of Cortex Moutan and Its Intestinal Absorption Characteristics

Ge¹,

Hou²,

Li³

et al. 2019

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Cortex Moutan (Paeonia suffruticosa Andr.) is a common traditional Chinese medicine and has been widely used in clinic for 2000 years in China. As sources for this crude drug are always mixed with other species, many cultivars on herbal market may lead to quality instability. Multi-component quantitative analysis is an efficient method to reflect chemical profiles of herb medicine and is always taken as the main method for quality evaluation. So, the aim of this work is to develop analytical method to quantify paeonol, paeoniflorin, gallic acid, oxypaeoniflorin, benzoylpaeoniflorin and paeonolide in Cortex Moutan (CM) to evaluate the chemical qualities of CM from different species or cultivars. Besides, we also study the intestinal absorption characteristics of paeonol and paeoniflorin for further pharmacological evaluation. In the present study, all of the standard markers were performed on an Ecosil C 18 (250 mm × 4.6 mm, 5 μM, Lubex Co., Guangzhou, China) with linear gradient elution of 0.2% formic acid water and acetonitrile. The proposed method was applied to analyze 50 batches of samples with acceptable linearity (R 2 , 0.9995-0.9999), precisions (RSD, 0.47%-2.08%), repeatability (RSD, 039%-2.63%), stability (RSD, 0.52%-2.45%), and recovery (RSD, 0.72%-3.03%) of the six compounds. Furthermore, the Hierarchical Cluster Analysis was applied to classify the 50 samples based on contents of the six compound markers. The results obtained from multi-component quantification of CM clearly indicated that CM originated from P. suffruticosa and P. ostii presented different chemical properties, and that samples from the two materials could be gathered into one branch, respectively, while CM sourced from cultivars of P. suffruticosa showed great variety on chemical quality. The results from Hierarchical Cluster Analysis implied that the established method could be used as a powerful tool for the quality evaluation of CM.

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Section: Introductionmentioning

confidence: 99%

Study on the Multi-Component Quantitation of Cortex Moutan and Its Intestinal Absorption Characteristics

Ge¹,

Hou²,

Li³

et al. 2019

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“…In our previous study, we showed that germacrone inhibits the proliferation and migration of MCF-7 breast cancer cells 5 by the inhibition of ERα signaling 24 . The expressions of the anti-apoptotic Bcl-2 and Bcl-xL protein and the pro-apoptotic TP53 and TP21 were dose-dependently regulated by germacrone as well 25 – 27 . While the research on curdione and furanodiene are limited, the results from this study provide a good starting point for further studies.…”

Section: Discussionmentioning

confidence: 96%

Predicted molecular targets and pathways for germacrone, curdione, and furanodiene in the treatment of breast cancer using a bioinformatics approach

Kong

et al. 2017

Sci Rep

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Germacrone, curdione, and furanodiene have been shown to be useful in the treatment of breast cancer but the pharmacological mechanism of action is unclear. In this paper, we explored a new method to study the molecular network and function of Traditional Chinese Medicine (TCM) herbs and their corresponding ingredients with bioinformatics tools, including PubChem Compound Database, BATMAN-TCM, SystemsDock, Coremine Medical, Gene ontology, and KEGG. Eleven targeted genes/proteins, 4 key pathways, and 10 biological processes were identified to participate in the mechanism of action in treating breast cancer with germacrone, curdione, and furanodiene. The information achieved by the bioinformatics tools was useful to interpretation the molecular mechanism for the treatment of germacrone, curdione, and furanodiene on breast cancers.

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“…It has been proved that Loquat leaf can inhibit a variety of cocci and bacillus [13] . Paeonol and the like in cortex moutan have anti-inflammatory effect [14] . The combined use of these drugs can relieve inflammation and eliminate skin lesions.…”

Section: Discussionmentioning

confidence: 99%

Study on traditional Chinese medicine medication for acne of wind-heat type in lung meridian based on data mining and network pharmacology

et al. 2021

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Acne vulgaris of wind-heat in lung meridian is a common skin disease, and there are many traditional Chinese medicine prescriptions, but the mechanism is still not clear. In this paper, the literature on the treatment of acne due to wind-heat in lung meridian and the prescriptions in the patents were collected and sorted out in the past twenty years. Excel 2019 was used for medication frequency statistics, and IBM SPSS 25.0 was used for clustering analysis to obtain the core formula. Network pharmacology was used to collect the related targets of drugs and diseases, to construct the action network, and to conduct enrichment analysis. A total of 137 prescriptions and 167 drugs were obtained. The core prescriptions were Cortex mori, Folium eriobotryae, Scutellariae radix, Glycyrrhrizae radix, Fructus gardeniae, Radix rehmanniae, and Cortex moutan. The treatment of acne due to wind-heat in lung meridian should begin with clearing heat, purging the lung, cooling blood and detoxicating. The core prescriptions mainly played a role through AKT1, IL6, TP53, TNF, VEGFA, EGF targets and Kaposi's sarcoma-related herpes virus infection, measles, toxoplasmosis, EB virus infection, IL-17, MAPK and other signaling pathways, so as to provide reference for further clinical research.

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Antibacterial and anticancer PDMS surface for mammalian cell growth using the Chinese herb extract paeonol(4-methoxy-2-hydroxyacetophenone)

Cited by 27 publications

References 32 publications

Study on the Multi-Component Quantitation of Cortex Moutan and Its Intestinal Absorption Characteristics

Study on the Multi-Component Quantitation of Cortex Moutan and Its Intestinal Absorption Characteristics

Predicted molecular targets and pathways for germacrone, curdione, and furanodiene in the treatment of breast cancer using a bioinformatics approach

Study on traditional Chinese medicine medication for acne of wind-heat type in lung meridian based on data mining and network pharmacology

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