Zika Virus and Guillain-BarrÉ Syndrome

Ma, Ellul; Cn, Soares; Solomon, Tom

doi:10.4997/jrcpe.2016.209

Cited by 5 publications

(3 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Most importantly, ZIKV infection in pregnant patients leads to microcephaly and congenital ZIKV syndrome in newborn infants [14,15,198,209,221,367]. Notably, ZIKV infection in adults results in Guillain-Barré syndrome [368,369,370,371,372,373,374,375]. Antiviral drugs for curing ZIKV are still unavailable but multiple kinds of vaccines have been initially developed and are anticipated to combat ZIKV infection [376,377,378,379,380].…”

Section: Flaviviridae Virusesmentioning

confidence: 99%

The Multifaceted Roles of Autophagy in Flavivirus-Host Interactions

2018

IJMS

View full text Add to dashboard Cite

Autophagy is an evolutionarily conserved cellular process in which intracellular components are eliminated via lysosomal degradation to supply nutrients for organelle biogenesis and metabolic homeostasis. Flavivirus infections underlie multiple human diseases and thus exert an immense burden on public health worldwide. Mounting evidence indicates that host autophagy is subverted to modulate the life cycles of flaviviruses, such as hepatitis C virus, dengue virus, Japanese encephalitis virus, West Nile virus and Zika virus. The diverse interplay between autophagy and flavivirus infection not only regulates viral growth in host cells but also counteracts host stress responses induced by viral infection. In this review, we summarize the current knowledge on the role of autophagy in the flavivirus life cycle. We also discuss the impacts of virus-induced autophagy on the pathogeneses of flavivirus-associated diseases and the potential use of autophagy as a therapeutic target for curing flavivirus infections and related human diseases.

show abstract

Section: Flaviviridae Virusesmentioning

confidence: 99%

The Multifaceted Roles of Autophagy in Flavivirus-Host Interactions

2018

IJMS

View full text Add to dashboard Cite

show abstract

“…ZIKV was first isolated nearly seventy years prior to the Brazilian outbreak of 2015 ( Dick et al, 1952 ; Zanluca et al, 2015 ), but the recent epidemic became associated with vertical transmission dynamics and congenital syndromes that were unprecedented for ZIKV or any other flavivirus ( Plourde and Bloch, 2016 ). Although infrequent neurological manifestations, including Guillain-Barre syndrome, meningitis, and meningoencephalitis, became linked to infection in adults ( Araujo et al, 2016 ; Avelino-Silva and Martin, 2016 ; Brasil et al, 2016 ; Ellul et al, 2016 ), the most severe neurological consequences were documented in infants born to mothers infected during pregnancy ( Barton and Salvadori, 2016 ; Melo et al, 2016 ). Referred to as congenital Zika syndrome (CZS) ( Moore et al, 2017 ), this collection of manifestations has provided the greatest justification to develop prophylactic and therapeutic countermeasures against the virus.…”

Section: Introductionmentioning

confidence: 99%

Zika virus infection during pregnancy protects against secondary infection in the absence of CD8+ cells

et al. 2021

View full text Add to dashboard Cite

While T cell immunity is an important component of the immune response to Zika virus (ZIKV) infection generally, the efficacy of these responses during pregnancy remains unknown. Here, we tested the capacity of CD8 lymphocytes to protect from secondary challenge in four macaques, two of which were depleted of CD8 + cells prior to rechallenge with a heterologous ZIKV isolate. The initial challenge during pregnancy produced transcriptional signatures suggesting complex patterns of immune modulation as well as neutralizing antibodies that persisted until rechallenge, which all animals efficiently controlled, demonstrating that the primary infection conferred adequate protection. The secondary challenge promoted activation of innate and adaptive immune cells, possibly suggesting a brief period of infection prior to clearance. These data confirm that ZIKV infection during pregnancy induces sufficient immunity to protect from a secondary challenge and suggest that this protection is not dependent on CD8 T cells.

show abstract

“…As many as 100 million cases of DENV infections in humans occur annually [4,5]. ZIKV not only has caused a wide-ranging pandemic in recent years but also is associated with severe diseases, such as microcephaly and other neurological symptoms of maldevelopment of the brain in neonates, and Guillain-Barré syndrome in adults [2,[6][7][8]. Most cases of infection occur in tropical and subtropical areas, where mosquitoes of the genus Aedes are the major vector for the transmission of DENV and ZIKV [9][10][11].…”

Section: Introductionmentioning

confidence: 99%

Syncytial and Congregative Effects of Dengue and Zika Viruses on the Aedes Albopictus Cell Line Differ among Viral Strains

et al. 2023

View full text Add to dashboard Cite

Objective: Dengue viruses (DENV) and Zika virus (ZIKV) are transmitted among humans, or from non-human primates to humans, through mosquito bites. The interaction of the virus with mosquito cells is a key step in the viral life cycle. Therefore, the objective of this study was to determine how DENV and ZIKV interact with mosquito cells. Methods: Immunofluorescence assays and a direct visualization system were combined to monitor the syncytial or congregative effects of DENV and ZIKV strains on C6/36 cells. We examined the cytopathic effects of the strains on C6/36 mosquito cells, a widely used laboratory model for studying infection with these viruses. Results: Our results indicated that all strains of DENV-1 and DENV-2, most DENV-4 strains, and some DENV-3 strains caused syncytial effects on C6/36 cells, whereas some DENV-3 and DENV-4 strains, and all tested ZIKV strains, caused cell congregation after infection but no cell fusion. In addition, we detected a range of environmental pH values from 6.0 to 8.0 supporting virus-induced cell fusion. The optimal pH condition was 7.5, at which viral production was also highest. Furthermore, the UV-inactivated virus did not cause cell fusion, thus suggesting that viral replication may be required for DENV’s syncytial effects on C6/36 cells. Conclusion: Syncytial and congregative effects of DENV and ZIKV on Aedes albopictus cells differ among viral strains. Syncytial effects of DENV on C6/36 are important for viral replication.

show abstract

Zika Virus and Guillain-BarrÉ Syndrome

Cited by 5 publications

References 17 publications

The Multifaceted Roles of Autophagy in Flavivirus-Host Interactions

The Multifaceted Roles of Autophagy in Flavivirus-Host Interactions

Zika virus infection during pregnancy protects against secondary infection in the absence of CD8+ cells

Syncytial and Congregative Effects of Dengue and Zika Viruses on the Aedes Albopictus Cell Line Differ among Viral Strains

Contact Info

Product

Resources

About