2017
DOI: 10.1111/jth.13575
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Abstract: Background Hemorrhage during transurethral resection of the prostate (TUR-P) has always been a concern. Several studies have shown preoperative administration of fibrinogen concentrate to have promising results in reducing hemorrhage in cardiac surgery. Objectives To investigate the hemostatic effect of fibrinogen concentrate administration on reducing the amount of bleeding during TUR-P in patients with benign prostatic hyperplasia. Methods Sixty men with benign prostatic hyperplasia, who were chosen to under… Show more

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Cited by 17 publications
(7 citation statements)
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“…Small uncontrolled studies evaluating FCs for perioperative use have yielded conflicting results, but most have been negative . When compared with placebo in seven randomized double‐blind studies, FCs failed to reduce bleeding or the need for allogeneic transfusion in cardiac surgery , urologic surgery , obstetric procedures , orthotopic liver transplantation and trauma . Conversely, two single‐center, randomized trials showed results that were at least partly positive.…”
Section: Fibrinogen Concentratesmentioning
confidence: 99%
“…Small uncontrolled studies evaluating FCs for perioperative use have yielded conflicting results, but most have been negative . When compared with placebo in seven randomized double‐blind studies, FCs failed to reduce bleeding or the need for allogeneic transfusion in cardiac surgery , urologic surgery , obstetric procedures , orthotopic liver transplantation and trauma . Conversely, two single‐center, randomized trials showed results that were at least partly positive.…”
Section: Fibrinogen Concentratesmentioning
confidence: 99%
“…21 As high fibrinogen concentration enhances clot firmness, restoration of depleted reserves has been introduced in clinical practice as a cost effective treatment able to decrease postoperative bleeding and transfusion. In a meta-analysis of 13 RCTs, Ng et al 22 observed that fibrinogen concentrate supplementation in adult surgical patients minimises postoperative bleeding in cardiac surgery, 23,24 urology, 25 liver transplantation, 26 and orthopaedics. 27 Notably, no patients undergoing open TAAA repair were included in the metaanalysis, albeit this surgery can be considered an archetype when analysing factors and therapies related to perioperative haemorrhage.…”
Section: Discussionmentioning
confidence: 99%
“…We found that the postoperative increase in fibrinogen concentration after intra-operative transfusion was inversely correlated with bleeding, consistent with the previously observed association. Fibrinogen has been tested in other operations, including cardiac [17][18][19][20][21], urological [22] and gynaecological [23], as well as after postpartum haemorrhage [24]. Some of these trials reported that fibrinogen reduced bleeding or transfusion [19][20][21].…”
Section: Discussionmentioning
confidence: 99%