Estimated cognitive decline in patients with schizophrenia: A multicenter study

Fujino, Haruo; Sumiyoshi, Chika; Yasuda, Yuka; Yamamori, Hidenaga; Fujimoto, Michiko; Fukunaga, Masaki; Miura, Kenichiro; Takebayashi, Yuto; Okada, Naohiro; Isomura, Shuichi; Kawano, Naoki; Toyomaki, Atsuhito; Kuga, Hironori; Isobe, Masanori; Oya, Kazuto; Okahisa, Yuko; Takaki, Manabu; Hashimoto, Naoki; Kato, Masaki; Onitsuka, Toshiaki; Ueno, Takefumi; Ohnuma, Tohru; Kasai, Kiyoto; Ozaki, Norio; Sumiyoshi, Tomiki; Imura, Osamu; Hashimoto, Ryota; Cocoro, for

doi:10.1111/pcn.12474

Cited by 54 publications

(70 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The subjects consisted of 171 patients with schizophrenia (60 for brain connectivity analysis) and 633 HC (234 for brain connectivity analysis). Diagnostic and exclusion criteria have been described previously . Written informed consent was obtained from all subjects after the procedures had been fully explained.…”

Section: Methodsmentioning

confidence: 99%

Brain morphological and functional features in cognitive subgroups of schizophrenia

Yasuda

Okada

Nemoto

et al. 2019

Psychiatry Clin Neurosci

Self Cite

View full text Add to dashboard Cite

Aim Previous studies have reported different brain morphologies in different cognitive subgroups of patients with schizophrenia. We aimed to examine the brain structures and functional connectivity in these cognitive subgroups of schizophrenia. Methods We compared brain structures among healthy controls and cognitively deteriorated and preserved subgroups of patients with schizophrenia according to the decline in IQ. Connectivity analyses between subcortical regions and other brain areas were performed using resting‐state functional magnetic resonance imaging among the groups. Results Whole brain and total cortical gray matter, right fusiform gyrus, left pars orbitalis gyrus, right pars triangularis, left superior temporal gyrus and left insula volumes, and bilateral cortical thickness were decreased in the deteriorated group compared to the control and preserved groups. Both schizophrenia subgroups had increased left lateral ventricle, right putamen and left pallidum, and decreased bilateral hippocampus, left precentral gyrus, right rostral middle frontal gyrus, and bilateral superior frontal gyrus volumes compared with controls. Hyperconnectivity between the thalamus and a broad range of brain regions was observed in the deteriorated group compared to connectivity in the control group, and this hyperconnectivity was less evident in the preserved group. We also found hyperconnectivity between the accumbens and the superior and middle frontal gyri in the preserved group compared with connectivity in the deteriorated group. Conclusion These findings provide evidence of prominent structural and functional brain abnormalities in deteriorated patients with schizophrenia, suggesting that cognitive subgroups in schizophrenia might be useful biotypes to elucidate brain pathophysiology for new diagnostic and treatment strategies.

show abstract

Section: Methodsmentioning

confidence: 99%

Brain morphological and functional features in cognitive subgroups of schizophrenia

Yasuda

Okada

Nemoto

et al. 2019

Psychiatry Clin Neurosci

Self Cite

View full text Add to dashboard Cite

show abstract

“…Multiple centers are cooperating by standardizing data acquisition methods, training inspection methods, and uniformly managing data quality. In addition to eye movements, we have also acquired multimodality data ranging from clinical indicators and cognitive function evaluation scales to neuroimaging data . We expect further research developments in the near future.…”

Section: Current Problems and The Establishment Of Large‐scale Multicmentioning

confidence: 99%

Eye movement characteristics in schizophrenia: A recent update with clinical implications

Morita

Miura

Kasai

et al. 2019

Neuropsychopharm Rep

Self Cite

View full text Add to dashboard Cite

Eye movements are indispensable for the collection of visual information in everyday life. Many findings regarding the neural basis of eye movements have been accumulated from neurophysiological and psychophysical studies. In the field of psychiatry, studies on eye movement characteristics in mental illnesses have been conducted since the early 1900s. Participants with schizophrenia are known to have characteristic eye movements during smooth pursuit, saccade control, and visual search. Recently, studies evaluating eye movement characteristics as biomarkers for schizophrenia have attracted considerable attention. In this article, we review the neurophysiological basis of eye movement control and eye movement characteristics in schizophrenia. Furthermore, we discuss the prospects for eye movements as biomarkers for mental illnesses.

show abstract

“…Discovery of disease‐specific biomarkers or behavioral indicators with sufficient sensitivity is an important issue to improve the clinical diagnosis of mental illness. Magnetic resonance images, near‐infrared spectroscopy, genetic markers, cognitive functions, and eye movements are candidates . Of them, eye movement is representative of sensorimotor functions of the brain, and eye movement abnormalities have been reported in subjects with schizophrenia .…”

Section: Introductionmentioning

confidence: 99%

Comparison of eye movements in schizophrenia and autism spectrum disorder

Shiino

Miura

Fujimoto

et al. 2019

Neuropsychopharm Rep

Self Cite

View full text Add to dashboard Cite

Aim Eye movement abnormalities are often associated with psychiatric illness. Subjects with either schizophrenia or autism spectrum disorder (ASD) have been reported to show eye movement abnormalities. However, it is still unclear whether eye movement abnormalities in schizophrenia and in ASD have common features. This study aimed to understand the similarities/differences in eye movement abnormalities of subjects with schizophrenia and those with ASD. Methods We analyzed 75 eye movement characteristics of 83 subjects with schizophrenia, 17 subjects with ASD and 255 healthy controls that were collected during fixation, smooth pursuit and free viewing tasks using analysis of covariance with the covariates age and sex. Results We found significant effects across groups on 21 eye movement characteristics, of which 4 characteristics had large effect sizes. Post hoc multiple comparisons indicated significant differences between the subjects with schizophrenia and healthy controls across all 21 characteristics. On the other hand, no significant difference between the ASD group and healthy control group was found. Instead, the subjects with ASD showed significant differences from the subjects with schizophrenia in 5 eye movement characteristics during the free viewing and smooth pursuit eye movements. Conclusions The present results suggest that eye movement abnormalities in the subjects with ASD are different from those with schizophrenia and that the tasks in this study are suitable to detect eye movement abnormality in schizophrenia. Thus, the eye movement examinations used here may distinguish subjects with schizophrenia from those with ASD.

show abstract

Estimated cognitive decline in patients with schizophrenia: A multicenter study

Abstract: These results show the distribution of difference score in patients with schizophrenia. These findings may contribute to assessing the severity of estimated cognitive decline and identifying patients with schizophrenia who suffer from cognitive decline.

Cited by 54 publications

References 37 publications

Brain morphological and functional features in cognitive subgroups of schizophrenia

Brain morphological and functional features in cognitive subgroups of schizophrenia

Eye movement characteristics in schizophrenia: A recent update with clinical implications

Comparison of eye movements in schizophrenia and autism spectrum disorder

Contact Info

Product

Resources

About