Epidemiology, risk factors, and prognosis of capillary leak syndrome in pediatric recipients of stem cell transplants: a retrospective single‐center cohort study

Lucchini, Giovanna; Willasch, André; Daniel, Julia E.; Soerensen, Jan; Jarisch, Andrea; Bakhtiar, Shahrzad; Rettinger, Eva; Brandt, Joerg; Klingebiel, Thomas; Bader, Peter

doi:10.1111/petr.12831

Cited by 26 publications

(24 citation statements)

References 16 publications

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“…A weight increase of at least 3% during 24 h is often used as a part of the diagnostic criteria for capillary leak syndrome [46]. This definition was used in a recent study of capillary leak syndrome in elderly allotransplanted pediatric patients whereas a weight criteria alone was used for the smallest children; these authors then described an association between capillary leak syndrome and decreased survival [47].…”

Section: Discussionmentioning

confidence: 99%

“…There is no generally accepted definition for capillary leak syndrome [49], but a definition including at least 3% weight gain during 24 h may be used [46]. As an alternative we therefore analyzed the impact of the maximal weight gain, and in contrast to the definition of capillary leak syndrome our parameter could be handled as a continuous variable in the survival analyses.…”

Section: Discussionmentioning

confidence: 99%

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Pretransplant Levels of CRP and Interleukin-6 Family Cytokines; Effects on Outcome after Allogeneic Stem Cell Transplantation

Tvedt

Lie

Reikvam

et al. 2016

IJMS

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Several pretransplant factors, including CRP (C-reactive protein) levels, reflect the risk of complications after allogeneic stem cell transplantation. IL-6 induces CRP increase, and we therefore investigated the effects of pretransplant IL-6, soluble IL-6 receptors, IL-6 family cytokines and CRP serum levels on outcome for 100 consecutive allotransplant recipients. All patients had related donors, none had active infections and 99 patients were in complete remission before conditioning. The incidence of acute graft versus host disease (aGVHD) requiring treatment was 40%, survival at Day +100 82%, and overall survival 48%. Despite a significant correlation between pretransplant CRP and IL-6 levels, only CRP levels significantly influenced transplant-related mortality (TRM). However, CRP did not influence overall survival (OS). Pretransplant IL-31 influenced late TRM. Finally, there was a significant association between pretransplant IL-6 and early postconditioning weight gain (i.e., fluid retention), and this fluid retention was a risk factor for aGVHD, TRM and OS. To conclude, pretransplant CRP, IL-31 and early posttransplant fluid retention were independent risk factors for TRM and survival after allotransplantation.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Pretransplant Levels of CRP and Interleukin-6 Family Cytokines; Effects on Outcome after Allogeneic Stem Cell Transplantation

Tvedt

Lie

Reikvam

et al. 2016

IJMS

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“…Allogeneic HCT from an unrelated donor, G-CSF administration, and intensive chemo/radiotherapy have been suggested as possible risk factors for CLS development [56,57]. A recent study in pediatric patients undergoing HCT [58] confirmed historical results suggesting that severe infection is associated with CLS, independently from HCT. This association is supposed to rely upon the endothelial damage induced by the cytokine storm that occurs in severe infection, which is believed to be crucial in the development of CLS.…”

Section: Evidence On the Endothelial Origin Of Vascular Endothelial Smentioning

confidence: 80%

Endothelial Dysfunction in Hematopoietic Cell Transplantation

Palomo¹,

Díaz‐Ricart²,

Carreras³

2019

CHI

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The goal of this review is to look at the role of endothelial damage and dysfunction in the initiation and development of early complications that appear after hematopoietic cell transplantation (HCT). These early complications share overlapping clinical manifestations and the suspicion of underlying endothelial damage. Several studies using different approaches, such as animal and in vitro models, the analysis of soluble biomarkers and clinical findings have provided evidence of this endothelial dysfunction. Historically, the first complication in which the role of endothelial damage was elucidated was the veno-oclusive disease/sinusoidal obstructive syndrome. In the last two decades, increasing evidence of the implication of the endothelium in the pathophysiology of other syndromes such as capillary leak syndrome, transplant-associated microangiopathy, or even graft versus host disease has accumulated. This knowledge opens up potential pharmacologic interventions to prevent/and/or treat endothelial damage and, therefore, to improve the outcome of patients receiving HCT.

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“…The average of the Ct value was calculated after the PCRs were run in duplicate for each sample. The cel-miR-39 value from the duplicate was used as the internal control [13, 30]. The relative expression of each miR-146a after normalization to cel-miR-39 is displayed as2 -[Ct (miRNA)- Ct (cel-miR-39)] .…”

Section: Methodsmentioning

confidence: 99%

Circulating MiR-146a May be a Potential Biomarker of Coronary Heart Disease in Patients with Subclinical Hypothyroidism

Xiaohui

Zhang

et al. 2018

Cell Physiol Biochem

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Background/Aims: Subclinical hypothyroidism (SCH) plays a crucial role in the development and progression of coronary heart disease (CHD). However, any associated changes in the circulating microRNAs (miRNAs) levels and slightly elevated thyroid stimulating hormone (TSH) levels in CHD patients are unknown. miR-146a is a well known miRNA associated with inflammatory autoimmune diseases. Here, we evaluated miR-146a expression in patients, with the goal of re-evaluating the effect of SCH on CHD. Methods: A total of 192 study subjects who underwent coronary angiography for either suspected or confirmed CHD were enrolled in 3 groups: CHD with SCH, CHD alone, and healthy controls. The circulating levels of miR-146a were quantified using qRT-PCR. Results: Levels of miR-146a were positively correlated with CHD severity, as indicated by the Gensini score (r=0.354). The relative expression of miR-146a in the CHD+SCH, CHD and healthy control groups was 2.223±0.827, 1.588±0.726 and 0.632±0.309, respectively. Plasma TSH levels were positively correlated with miR-146a levels (r=0.321). According to multivariate logistic regression analyses, miR-146a levels were associated with the incidence of CHD in patients with SCH. For diagnosing CHD, the area under the ROC curve (AUC) of miR-146a and TSH was 0.779 and 0.752, respectively. When the TSH and miR-146a levels were combined to form a composite panel, the AUC of the panel was 0.858. Conclusion: Plasma miR-146a levels correlated with the severity of coronary atherosclerosis and increased with TSH slightly elevated in patients with CHD. Thus, miR-146a may have good predictive value for CHD among individuals with elevated TSH levels.

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Epidemiology, risk factors, and prognosis of capillary leak syndrome in pediatric recipients of stem cell transplants: a retrospective single‐center cohort study

Cited by 26 publications

References 16 publications

Pretransplant Levels of CRP and Interleukin-6 Family Cytokines; Effects on Outcome after Allogeneic Stem Cell Transplantation

Pretransplant Levels of CRP and Interleukin-6 Family Cytokines; Effects on Outcome after Allogeneic Stem Cell Transplantation

Endothelial Dysfunction in Hematopoietic Cell Transplantation

Circulating MiR-146a May be a Potential Biomarker of Coronary Heart Disease in Patients with Subclinical Hypothyroidism

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