Multifunctional nanogels with dual temperature and pH responsiveness

Niţă, Loredana E.; Chiriac, Aurica P.; Diaconu, Alina; Tudorachi, Niță; Mititelu-Tarțău, Liliana

doi:10.1016/j.ijpharm.2016.10.017

Cited by 25 publications

(8 citation statements)

References 22 publications

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“…Fundamental and applied research on aerogels for biomedical and environmental applications should be conducted to impart aerogels application-specific properties such as hydrophilicity, lipophilicity, ultra-low density, flame retardation, tailored porosity, nanomorphology and surface chemistry [99,100]. Fundamental research includes the study of biopolymer self-assembling in solution state, coagulation after anti-solvent addition and gel formation.…”

Section: Prospects and Challenges In Aerogel Researchmentioning

confidence: 99%

An Opinion Paper on Aerogels for Biomedical and Environmental Applications

et al. 2019

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Aerogels are a special class of nanostructured materials with very high porosity and tunable physicochemical properties. Although a few types of aerogels have already reached the market in construction materials, textiles and aerospace engineering, the full potential of aerogels is still to be assessed for other technology sectors. Based on current efforts to address the material supply chain by a circular economy approach and longevity as well as quality of life with biotechnological methods, environmental and life science applications are two emerging market opportunities where the use of aerogels needs to be further explored and evaluated in a multidisciplinary approach. In this opinion paper, the relevance of the topic is put into context and the corresponding current research efforts on aerogel technology are outlined. Furthermore, key challenges to be solved in order to create materials by design, reproducible process technology and society-centered solutions specifically for the two abovementioned technology sectors are analyzed. Overall, advances in aerogel technology can yield innovative and integrated solutions for environmental and life sciences which in turn can help improve both the welfare of population and to move towards cleaner and smarter supply chain solutions.

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Section: Prospects and Challenges In Aerogel Researchmentioning

confidence: 99%

An Opinion Paper on Aerogels for Biomedical and Environmental Applications

et al. 2019

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“…Monoresponsive nanogels cannot maintain the controlled drug release effectively, so nanogels with dual-or multi-stimuli responsiveness have attracted widespread attention [50][51][52][53]. Among the multiresponsiveness combinations, pH-temperature dual-sensitivity combinations have been studied with considerable advances.…”

Section: Multistimuli-responsive Nanogelsmentioning

confidence: 99%

Nanogel: A Versatile Nano-Delivery System for Biomedical Applications

et al. 2020

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Nanogel-based nanoplatforms have become a tremendously promising system of drug delivery. Nanogels constructed by chemical crosslinking or physical self-assembly exhibit the ability to encapsulate hydrophilic or hydrophobic therapeutics, including but not limited to small-molecule compounds and proteins, DNA/RNA sequences, and even ultrasmall nanoparticles, within their 3D polymer network. The nanosized nature of the carriers endows them with a specific surface area and inner space, increasing the stability of loaded drugs and prolonging their circulation time. Reactions or the cleavage of chemical bonds in the structure of drug-loaded nanogels have been shown to trigger the controlled or sustained drug release. Through the design of specific chemical structures and different methods of production, nanogels can realize diverse responsiveness (temperature-sensitive, pH-sensitive and redox-sensitive), and enable the stimuli-responsive release of drugs in the microenvironments of various diseases. To improve therapeutic outcomes and increase the precision of therapy, nanogels can be modified by specific ligands to achieve active targeting and enhance the drug accumulation in disease sites. Moreover, the biomembrane-camouflaged nanogels exhibit additional intelligent targeted delivery features. Consequently, the targeted delivery of therapeutic agents, as well as the combinational therapy strategy, result in the improved efficacy of disease treatments, though the introduction of a multifunctional nanogel-based drug delivery system.

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“…[340] In essence, there is little difference between nanogels and microgels, except the application scenarios caused by the size effects (e.g., nanogels can easily permeate due to their extremely small size and, more specifically, can cross the blood-brain barrier) and some specific functions (e.g., nanogels have non-immunological responses, and invasion by the reticuloendothelial system is prevented) are different. [341,342] Due to the high stability, biodegradability, biocompatibility, large surface area, long circulation time in blood, tunable size, and minimal resources required to manufacture nanogels, nanogels (administered by oral, pulmonary, nasal, ocular, and topical routes) have attracted great attention for nanomedicine applications, for instance, as pharmaceutical drug carriers. [341,[343][344][345][346] Akiyoshi et al [347] focused on amphiphilic polysaccharide self-assembled nanogels (self-nanogels) and their application in immunotherapy because one of the most attractive characteristics of self-nanogels is their ability to function as molecular chaperones, which enables them to capture various protein and peptide molecules within their polymer matrix via the formation of hydrophobic interactions.…”

Section: Nanogelsmentioning

confidence: 99%

Hydrogel: Diversity of Structures and Applications in Food Science

Jia

Luo

2021

Food Reviews International

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Hydrogels are a series of soft and wet materials with three dimensions of crosslinked networks. Hydrogels have attracted great attention due to their diverse functional properties, and their wide range of applications, such as in soft robots and actuators, stretched electronic devices, tissue engineering materials, controlled-release drug delivery vehicles, biomedicine materials, food science, and (bio)sensors. In general, there are four core concerns in hydrogel science, including the polymer source, structure fabrication, gel function, and gel applications. According to the logic that the "structure determines function", it is believed that rational design of structures can effectively regulate the functions and applications of hydrogels. Hence, in the current review, "structure" as the core topic will be highly regarded, and the crosslinking mechanisms and structural diversity of hydrogels are comprehensively summarized. Additionally, hydrogels also show their great application potential in food science. Hence, the current review also pays more attention to the application of hydrogels in food nutrition and health, food engineering and processing, and food safety. It is whished that this review not only serves as a reference for improving the comprehensive understanding of the structural design of hydrogels but also provides a forward-looking idea for hydrogel applications in food science.

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Multifunctional nanogels with dual temperature and pH responsiveness

Cited by 25 publications

References 22 publications

An Opinion Paper on Aerogels for Biomedical and Environmental Applications

An Opinion Paper on Aerogels for Biomedical and Environmental Applications

Nanogel: A Versatile Nano-Delivery System for Biomedical Applications

Hydrogel: Diversity of Structures and Applications in Food Science

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