2016
DOI: 10.1021/acs.biochem.6b00790
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Abstract: The suggested bat origin for Middle East respiratory syndrome coronavirus (MERS-CoV) has revitalized the studies of other bat-derived coronaviruses with respect to interspecies transmission potential. Bat coronavirus (BatCoV) HKU9 is an important betacoronavirus (betaCoV) that is phylogenetically affiliated with the same genus as MERS-CoV. The bat surveillance data indicated that BatCoV HKU9 has been widely spreading and circulating in bats. This highlights the necessity of characterizing the virus for its pot… Show more

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Cited by 23 publications
(27 citation statements)
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References 57 publications
(141 reference statements)
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“…The structure, solved through the molecular replacement method, contains a single molecule in the crystallographic asymmetric unit, with an R work of 0.2160 and an R free of 0.2585 (Table 1). Like the other solved CTD structures of betaCoVs (Huang et al, 2016;Kirchdoerfer et al, 2016;F. Li et al, 2005;Lu et al, 2013;Walls et al, 2016;Wang et al, 2013Wang et al, , 2014, HKU5-CTD folds into two discrete subdomains, the core and the external (Fig.…”
Section: Overall Structure Of the Hku5-ctdmentioning
confidence: 62%
See 3 more Smart Citations
“…The structure, solved through the molecular replacement method, contains a single molecule in the crystallographic asymmetric unit, with an R work of 0.2160 and an R free of 0.2585 (Table 1). Like the other solved CTD structures of betaCoVs (Huang et al, 2016;Kirchdoerfer et al, 2016;F. Li et al, 2005;Lu et al, 2013;Walls et al, 2016;Wang et al, 2013Wang et al, , 2014, HKU5-CTD folds into two discrete subdomains, the core and the external (Fig.…”
Section: Overall Structure Of the Hku5-ctdmentioning
confidence: 62%
“…To date, seven structures of CTDs covering all four lineages of betaCoVs have been solved. They are HKU1-CTD and MHV-CTD, belonging to lineage A (Kirchdoerfer et al, 2016;Walls et al, 2016), MERS-RBD/CTD Wang et al, 2013), HKU4-RBD/ CTD , and HKU5-CTD grouped in lineage C (reported here), and SARS-RBD/CTD (F. Li et al, 2005) and HKU9-CTD (Huang et al, 2016) representing lineages B and D, respectively. All seven betaCoV CTD structures display a conserved core subdomain, with five antiparallel beta strands and a conserved disulfide bond between βc2 and βc4 ( Fig.…”
Section: Conserved Core Subdomain and Variable External Subdomain Formentioning
confidence: 63%
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“…The receptor binding domain (RBD) of the coronavirus spike (S) protein recognizes host receptors to mediate virus entry and is therefore a key factor determining the viral tropism and transmission capacity. A study by Huang et al (2016) has characterized RBD to the host receptors via SPR providing structural details of RBD being composed of core and external subdomain and intersubdomain that anchors external subdomain to core subdomain. The structural insights provide crucial information on the evolutionary trajectory of betaCoV (Huang et al, 2016).…”
Section: Evolution Of Betacoronavirus Receptor Binding Motifsmentioning
confidence: 99%