2016
DOI: 10.18097/pbmc20166204369
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Abstract: Систематизированы данные по химическому составу веществ тритерпеновой и стероидной природы, выделенных из чаги, как выращенной в условиях искусственной культуры, так и произрастающей в природе. Приведены сведения по биологической активности экстрактов из чаги и этих соединений в отношении различных линий клеток рака in vitro и in vivо. Проведённый анализ позволил выявить определенные закономерности в эффективности подавления роста различных линий клеток. Установлено, что наибольшей активностью обладают тритерп… Show more

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Cited by 12 publications
(8 citation statements)
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“…The results showed that [BMIM] Br exerted the best extraction effect (Figure 2A). Under the same extraction conditions, the amounts of total triterpenoids obtained after performing ultrasonic-assisted extraction (UAE) were as follows: 9 2A). These data show that when anions are the same, the total triterpenoid content first increases and then decreases with increasing carbon chain length regardless of using UAE or HAE.…”
Section: Differences In Total Triterpenoid Content Extracted Using Seven Il Typesmentioning
confidence: 99%
See 1 more Smart Citation
“…The results showed that [BMIM] Br exerted the best extraction effect (Figure 2A). Under the same extraction conditions, the amounts of total triterpenoids obtained after performing ultrasonic-assisted extraction (UAE) were as follows: 9 2A). These data show that when anions are the same, the total triterpenoid content first increases and then decreases with increasing carbon chain length regardless of using UAE or HAE.…”
Section: Differences In Total Triterpenoid Content Extracted Using Seven Il Typesmentioning
confidence: 99%
“…Triterpenoids are substances with several (generally six) condensed isoprene formed by hydroxyl removal and are essential products of isoprene metabolism [ 9 ]. Although most of these are composed of 30 carbon atoms, some have only 27 carbon atoms.…”
Section: Introductionmentioning
confidence: 99%
“…Nikitina S.A., Khabibrakhmanova V.R., Sysoeva M.A. (2016) summarized data on the chemical composition of triterpene and steroid compounds isolated from chaga mushroom grown in natural conditions or in synthetic culture [25]. Particular attention was paid to the biological activity of chaga mushroom extracts and these specific compounds against various cancer cell lines in vitro and in vivo.…”
Section: R E S E a R C H R E S U L T Smentioning
confidence: 99%
“…This analysis demonstrated some common features in the inhibition of growth of various cell lines by components of the chaga fungus. In this context, triterpene compounds containing an OH group at C22 and a side chain unsaturated bond are the most active [25]. Zhang P., Cao X., Li C., et al (2016) studied the role of the squalene synthase gene isolated from Inonotus obliquus in triterpene synthesis by detecting squalene in vitro in a reaction mixture of particles using high-performance liquid chromatographic analysis [34].…”
Section: R E S E a R C H R E S U L T Smentioning
confidence: 99%
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