The impact of 2015 neuromyelitis optica spectrum disorders criteria on diagnostic rates

Hamid, Shahd; Elsone, Liene; Mutch, Kerry; Solomon, Tom; Jacob, Anu

doi:10.1177/1352458516663853

Cited by 55 publications

(40 citation statements)

References 17 publications

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“…criteria, despite use of AQP4-IgG serologic status (17). Hamid et al (18) reported an increase in NMOSD diagnosis of 76% compared with use of the 2006 criteria.…”

Section: Introductionmentioning

confidence: 99%

Neuromyelitis Optica Spectrum Disorders: Spectrum of MR Imaging Findings and Their Differential Diagnosis

et al. 2018

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Neuromyelitis optica (NMO) is an autoimmune demyelinating disorder for which the aquaporin-4 (AQP4) water channels are the major target antigens. Advances in the understanding of NMO have clarified several points of its pathogenesis, clinical manifestations, and imaging patterns. A major advance was the discovery of the AQP4 antibody, which is highly specific for this disorder. Descriptions of new clinical and radiologic features in seropositive patients have expanded the spectrum of NMO, and the term NMO spectrum disorder (NMOSD) has been adopted. NMOSD is now included in a widening list of differential diagnoses. Acknowledgment of NMOSD imaging patterns and their mimicry of disorders has been crucial in supporting early NMOSD diagnosis, especially for unusual clinical manifestations of this demyelinating disease. This pictorial review summarizes the wide imaging spectrum of NMOSD and its differential diagnosis, as well as its historical evolution, pathophysiology, and clinical manifestations. RSNA, 2018.

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“…criteria, despite use of AQP4-IgG serologic status (17). Hamid et al (18) reported an increase in NMOSD diagnosis of 76% compared with use of the 2006 criteria.…”

Section: Introductionmentioning

confidence: 99%

Neuromyelitis Optica Spectrum Disorders: Spectrum of MR Imaging Findings and Their Differential Diagnosis

et al. 2018

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“…Based on the criteria of the 2015 International Panel for NMO Diagnosis guidelines, approximately 73–90% of patients with NMOSD express AQP4‐IgG . Therefore, the remaining 10–27% of patients diagnosed with one of the groups of demyelinating disorders are classified as having AQP4‐IgG‐seronegative NMOSD.…”

Section: Aqp4‐igg‐seronegative Nmosdmentioning

confidence: 99%

Review: Recent advances in the understanding of the pathophysiology of neuromyelitis optica spectrum disorder

Chang

2019

Neuropathology Appl Neurobio

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Review: Recent advances in the understanding of the pathophysiology of neuromyelitis optica spectrum disorderNeuromyelitis optica is an autoimmune inflammatory disorder of the central nervous system that preferentially targets the spinal cord and optic nerve. Following the discovery of circulating antibodies against the astrocytic aquaporin 4 (AQP4) water channel protein, recent studies have expanded our knowledge of the unique complexities of the pathogenesis of neuromyelitis optica and its relationship with the immune response. This review describes and summarizes the recent advances in our understanding of the molecular mechanisms underlying neuromyelitis optica disease pathology and examines their potential as therapeutic targets. Additionally, we update the most recent research by proposing major unanswered questions regarding how peripheral AQP4 antibodies are produced and their entry into the central nervous system, the causes of AQP4-IgG-seronegative disease, why peripheral AQP4-expressing organs are spared from damage, and the impact of this disease on pregnancy.

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“…In 2015, IPND unified the term NMO and NMOSD, and developed the new diagnostic criteria of NMOSD, based on the occurrence of core clinical characteristics with or without detection of AQP4 antibody. 9 The core clinical characteristics include the following:…”

Section: Discussionmentioning

confidence: 99%

“…14 The AQP4 serum autoantibody, also known as NMOIgG, has a sensitivity of 91% and specificity of 100% for NMO, and is positive in up to 80% of patients. 9 The AQP4 is a water channel in the brain, which is highly localized in astrocytes. These antibodies may be responsible for a variety of immune events which includes immunoglobulin deposition, demyelination, and complement-mediated cytotoxicity.…”

Section: Discussionmentioning

confidence: 99%

Neuropathic pruritus: an early indicator of neuromyelitis optica spectrum disorders

et al. 2018

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Neuromyelitis optica is a relapsing, inflammatory astrocytopathic disorder, affecting predominantly the optic nerves and spinal cord. It is associated with antiaquaporin-4 immunoglobulin G (AQP4-IgG) in up to 70% of patients. Spinal cord involvement typically presents as a longitudinally-extensive transverse myelitis, with associated sensorimotor and sphincter dysfunction. Sensory symptoms such as numbness, dysaesthesia, pain and tonic spasms are common. Here, we present a case of a 25years old female who came to the medicine OPD, with the chief complaints of intense itching over face and forehead, which was later on progressed to quadriparesis after 3 weeks. This case highlights neuropathic pruritus as an under-recognised early feature of neuromyelitis optica.

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The impact of 2015 neuromyelitis optica spectrum disorders criteria on diagnostic rates

Abstract: Application of the 2015 criteria led to a rise in diagnosis of NMOSD by 76%. The rise in the AQP4 IgG +ve group contributed 62% and the seronegative group contributed 14%.

Cited by 55 publications

References 17 publications

Neuromyelitis Optica Spectrum Disorders: Spectrum of MR Imaging Findings and Their Differential Diagnosis

Neuromyelitis Optica Spectrum Disorders: Spectrum of MR Imaging Findings and Their Differential Diagnosis

Review: Recent advances in the understanding of the pathophysiology of neuromyelitis optica spectrum disorder

Neuropathic pruritus: an early indicator of neuromyelitis optica spectrum disorders

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