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Cited by 24 publications
(26 citation statements)
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References 64 publications
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“…There are a number of studies demonstrating the antioxidant effect of MB in cell cultures exposed to exogenous H 2 O 2 or rotenone . Other studies showed that MB increased the production of H 2 O 2 in isolated brain mitochondria . In our experiments, 0.5 μ m MB increased the rate of H 2 O 2 production from 76.3 ± 16.6 to 1170 ± 20 pmol·min −1 ·mg −1 in isolated brain mitochondria oxidizing pyruvate + malate.…”
Section: Resultssupporting
confidence: 56%
“…There are a number of studies demonstrating the antioxidant effect of MB in cell cultures exposed to exogenous H 2 O 2 or rotenone . Other studies showed that MB increased the production of H 2 O 2 in isolated brain mitochondria . In our experiments, 0.5 μ m MB increased the rate of H 2 O 2 production from 76.3 ± 16.6 to 1170 ± 20 pmol·min −1 ·mg −1 in isolated brain mitochondria oxidizing pyruvate + malate.…”
Section: Resultssupporting
confidence: 56%
“…At face value, these data would seem to indicate that a fine line exists in the utilization of Methylene Blue to promote mitochondrial function and that care should be taken to generate rigorous dose-response curves for this compound. Alternatively, these data could point to other neuroprotective mechanisms being utilized by Methylene Blue, including activation of endogenous antioxidant systems such as Nrf2 by increasing mitochondrial ROS production, or perhaps by increasing mitochondrial biogenesis by reducing mitochondrial respiration [93]. Regardless, Methylene Blue offers a valid approach to reduce the effects of bioenergetics failure following TBI and may still prove to be a “magic bullet”.…”
Section: Discussionmentioning
confidence: 99%
“…Those studies are generally focusing on the photosensitizer properties of MB, which lead to singlet oxygen generation (Oliveira et al, 2011). Also, it was shown that MB in concentrations of 1 μM and during the chronic drug administration contributes to the increase in the production of H 2 O 2 in isolated brain mitochondria (Gureev et al, 2016;Tretter et al, 2014).…”
Section: Introductionmentioning
confidence: 99%
“…Pharmacokinetics of MB is somewhat different when it is administered orally since a significant portion is excreted in the urine (Peter et al, 2000). Using the 5 mg/kg/day MB does not induce any significant therapeutic effect (Gureev et al, 2016) and the optimal results for this type of administration are shown to be at concentrations ranging from 15 to 40 mg/ kg/day (Eroğlu and Cağlayan, 1997;Gureev et al, 2016;Stack et al, 2014). In any way MB is characterized by an inverted U-shaped curve typical of hormesis (Rojas et al, 2012).…”
Section: Introductionmentioning
confidence: 99%