The effects of intranasal oxytocin in opioid-dependent individuals and healthy control subjects: a pilot study

Woolley, Josh; Arcuni, Peter A.; Stauffer, Christopher S.; Fulford, Daniel; Carson, Dean S.; Batki, Steve; Vinogradov, Sophia

doi:10.1007/s00213-016-4308-8

Cited by 38 publications

(19 citation statements)

References 60 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Furthermore, a single dose of intranasal oxytocin application was not successful in reducing opioid craving [38]. Our findings suggested that the interaction between oxytocin and craving is complicated, and personality traits (novelty-seeking) might play roles as mediating or modulating variables.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

The Association between the Level of Plasma Oxytocin and Craving among Former Heroin Users

et al. 2018

View full text Add to dashboard Cite

Background: Animal studies have demonstrated that oxytocin can influence addiction behaviors and might interact with the dopaminergic system, which is a key component of addiction behaviors. However, related evidence from clinical studies is scarce. The aim of our study was to explore the relationship between plasma oxytocin level and heroin craving among patients receiving methadone maintenance treatment, and to ascertain whether this relationship is moderated by novelty-seeking. Methods: The study was conducted in a methadone maintenance therapy clinic of a medical center in Taiwan. Seventy-seven patients with heroin addiction were enrolled. Plasma oxytocin was measured using an ELISA kit. Craving was assessed using an established instrument, the Chinese Craving Scale. Results: A significant negative association was found between the plasma oxytocin level and craving score, which remained robust after controlling the effects of social support and low-density lipoprotein cholesterol. An interaction between oxytocin and novelty-seeking indicated that this relationship was stronger among patients with a lower level of novelty-seeking. Conclusion: This finding may be taken into account in future studies and may provide a basis for the development of potential treatment for addiction. The effect of oxytocin for the treatment of opioid dependence might be modulated by some psychological factors.

show abstract

Section: Discussionmentioning

confidence: 99%

“…A single dose of intranasal oxytocin did not reduce cue-induced opioid craving [38]; however, a different 2-week trial indicated that intranasal oxytocin suppressed heroin craving [39]. A recent study demonstrated an unexpectedly higher level of oxytocin among abstinent heroin addicts than controls [40].…”

Section: Introductionmentioning

confidence: 99%

The Association between the Level of Plasma Oxytocin and Craving among Former Heroin Users

et al. 2018

View full text Add to dashboard Cite

show abstract

“…In a randomized, double‐blind, placebo‐controlled, crossover study, Woolley et al . () reported that intranasal OT administration (40 IU) did not improve cue‐induced craving in opioid‐dependent subjects receiving opioid replacement therapy. In contrast, in a placebo‐controlled trial of individuals undergoing methadone replacement treatment for opioid and co‐occurring cocaine use disorder, placebo‐treated patients reported an increase for heroin craving, while individuals who received intranasal OT treatment (40 IU; two times daily × 2 weeks) did not exhibit increased craving response (Stauffer et al , ), providing some promise for the treatment of this population.…”

Section: Effects Of Opioid Addiction On the Oxytocinergic Systemmentioning

confidence: 99%

“…There is currently a limited number of clinical trials investigating the efficacy of OT in the treatment of drug addiction. With regards to opioid addiction, there have been only two clinical studies to‐date that assessed the effects of intranasal OT on opioid‐dependent patients (Stauffer et al , ; Woolley et al , ). The main outcome of both studies demonstrates a safe and good tolerability profile of OT administration in opioid‐dependent individuals, even after repeated administration for 2 weeks.…”

Section: Effects Of Opioid Addiction On the Oxytocinergic Systemmentioning

confidence: 99%

Oxytocin and opioid addiction revisited: old drug, new applications

Zanos

Georgiou

Weber

et al. 2017

British J Pharmacology

View full text Add to dashboard Cite

show abstract

“…A growing number of trials are exploring intranasal oxytocin as a potential drug in the treatment of alcohol use disorder and substance abuse, yet so far with mixed results [13][14][15][16][17]. One pilot trial suggested that the anxiolytic effects of intranasal oxytocin may be favorable in reducing alcohol withdrawal symptoms [18].…”

Section: Introductionmentioning

confidence: 99%

Actigraphy assessment of motor activity and sleep in patients with alcohol withdrawal syndrome and the effects of intranasal oxytocin

et al. 2020

View full text Add to dashboard Cite

Background and aims The alcohol withdrawal syndrome increases autonomic activation and stress in patients during detoxification, leading to alterations in motor activity and sleep irregularities. Intranasal oxytocin has been proposed as a possible treatment of acute alcohol withdrawal. The aim of the present study was to explore whether actigraphy could be used as a tool to register symptoms during alcohol detoxification, whether oxytocin affected actigraphy variables related to motor activity and sleep compared to placebo during detoxification, and whether actigraphy-recorded motor function during detoxification was different from that in healthy controls. Methods This study was a part of a randomized, double blind, placebo-controlled trial in which 40 patients with alcohol use disorder admitted for acute detoxification were included. Of these, 20 received insufflations with intranasal oxytocin and 20 received placebo. Outcomes were actigraphy-recorded motor activity during 5-hour sequences following the insufflations and a full 24-hour period, as well as actigraphy-recorded sleep. Results were related to clinical variables of alcohol intake and withdrawal, including self-reported sleep. Finally, the actigraphy results were compared to those in a group of 34 healthy individuals.

show abstract

The effects of intranasal oxytocin in opioid-dependent individuals and healthy control subjects: a pilot study

Abstract: Methadone Oxytocin Option. ClinicalTrials.gov identifier: NCT01728909.

Cited by 38 publications

References 60 publications

The Association between the Level of Plasma Oxytocin and Craving among Former Heroin Users

The Association between the Level of Plasma Oxytocin and Craving among Former Heroin Users

Oxytocin and opioid addiction revisited: old drug, new applications

Actigraphy assessment of motor activity and sleep in patients with alcohol withdrawal syndrome and the effects of intranasal oxytocin

Contact Info

Product

Resources

About