2016
DOI: 10.1111/aas.12734
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Abstract: The available evidence directly comparing fibrinogen concentrate to cryoprecipitate is sparse and with high risk of bias. Recommendation of one product over the other for fibrinogen substitution in the bleeding patient with acquired hypofibrinogenaemia is currently not possible. Future research should guide us towards evidence-based decisions of product superiority.

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Cited by 60 publications
(52 citation statements)
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“…The utility of early fibrinogen replacement using FC and/or cryoprecipitate is gaining popularity but at the current time is not supported by high quality evidence (161). In the last decade there has been a vast amount of literature published regarding traumatic coagulopathy and transfusion strategies.…”
Section: Fibrinogen Trials In Traumatic Haemorrhagementioning
confidence: 99%
“…The utility of early fibrinogen replacement using FC and/or cryoprecipitate is gaining popularity but at the current time is not supported by high quality evidence (161). In the last decade there has been a vast amount of literature published regarding traumatic coagulopathy and transfusion strategies.…”
Section: Fibrinogen Trials In Traumatic Haemorrhagementioning
confidence: 99%
“…This occurred because the design of this study was to compare clinical dosing rather than dosing matched by fibrinogen content of the products; therefore, the final concentration in the FC contained 24% and 36% more fibrinogen versus PR Cryo and Cryo, respectively. Notably, a recent systematic review did not find evidence that either cryoprecipitate or FC was superior in terms of efficacy and safety . Both FC and cryoprecipitate have been successfully used to treat acquired hypofibrinogenemia in various settings …”
Section: Discussionmentioning
confidence: 99%
“…The cost of fibrinogen concentrate is approximately four to five times more per gram of fibrinogen compared to cryoprecipitate . A systematic review of the current literature could make no overall recommendations with regard to which product is superior …”
mentioning
confidence: 99%
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“…A systematic review compared cryoprecipitate with fibrinogen concentrate in patients with bleeding. 55 There was very little available evidence directly comparing fibrinogen concentrate with cryoprecipitate (the review included one RCT and four observational studies). The included studies showed no differences in fibrinogen-level increase, bleeding, red cell transfusions, or thromboembolic complications, and all studies were at risk of bias and the authors concluded that further high-quality trials were needed.…”
mentioning
confidence: 99%