2016
DOI: 10.1016/j.ctrv.2016.03.010
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Abstract: Background Most non-oncologic clinical practice guidelines recommend restrictive allogeneic blood transfusion practices; however, there is a lack of consensus regarding the best transfusion practice in oncology. We conducted a systematic review of the literature to compare the efficacy and safety of restrictive versus liberal transfusion strategies in patients with cancer. Methods A literature search using MEDLINE, PUBMED and EMBASE identified all controlled studies comparing the use of restrictive with libe… Show more

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Cited by 37 publications
(34 citation statements)
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References 43 publications
(94 reference statements)
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“…In this regard, the optimal transfusion threshold, dosing, and age of red blood cell (RBC) units have been studied. At present, a restrictive transfusion threshold is recommended for hospitalized adult patients and seems to be safe in the oncologic setting . Moreover, standard‐issue RBC units rather than fresh RBC units (storage length, <10 days) and, to initiate, 1 rather than 2 RBC units are advised .…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…In this regard, the optimal transfusion threshold, dosing, and age of red blood cell (RBC) units have been studied. At present, a restrictive transfusion threshold is recommended for hospitalized adult patients and seems to be safe in the oncologic setting . Moreover, standard‐issue RBC units rather than fresh RBC units (storage length, <10 days) and, to initiate, 1 rather than 2 RBC units are advised .…”
Section: Discussionmentioning
confidence: 99%
“…At present, a restrictive transfusion threshold is recommended for hospitalized adult patients and seems to be safe in the oncologic setting. 28,29 Moreover, standard-issue RBC units rather than fresh RBC units (storage length, <10 days) and, to initiate, 1 rather than 2 RBC units are advised. 29 Although we corrected our results for the year of treatment, the combined efforts to optimize colorectal cancer care (e.g., centralization, protocols, laparoscopy) might have contributed differently to the results.…”
Section: Discussionmentioning
confidence: 99%
“…In terms of RBC transfusion, the goal is to achieve a balance between transfusing enough blood to prevent end organ damage and overtransfusing, exposing the patient to unnecessary risks of transfusion including exposure to infectious agents, transfusion reactions, and the possibility of alloimmunization. [1][2][3]7,8 The decision to transfuse is commonly initiated or triggered by Hb or Hct thresholds that have been well-defined over the past decade and are based on evidence in support of restrictive transfusion practices. These recommendations have been formalized in the AABB guidelines and guidelines from other groups.…”
Section: Discussionmentioning
confidence: 99%
“…What are the physiologic responses, clinical consequences, and optimal use of RBC transfusions in children with anemia due to marrow failure? 30 The fate of transfused RBCs and free non-transferrin-bound iron in patients with primary or treatment-related marrow aplasia may differ from patients with "consumptive" causes including hemorrhage or inflammatory-driven anemia. Recent guidelines encourage measuring iron burden in chronically transfused oncology and transplant patients, but the effects and management of iron overload and its consequences are poorly understood in children with malignancies.…”
Section: How Can Plt Transfusions Be Optimized Including Plt Refractomentioning
confidence: 99%