2016
DOI: 10.1111/trf.13484
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Use of n‐of‐1 (single patient) trials to assess the effect of age of transfused blood on health‐related quality of life in transfusion‐dependent patients

Abstract: In chronically transfused patients, there were no significant differences in HRQL or Hb levels between fresh versus standard blood. While larger trials are needed, these results support current practices in hospital blood transfusion laboratories using a first-in, first-out model of blood utilization for these transfusion-dependent patients. Use of n-of-1 trials to determine the benefits of transfusions in single patients appears to be feasible.

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Cited by 6 publications
(1 citation statement)
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“…Feasibility was assessed in terms of attendance, drop out, and the challenges related to implementing the pilot, and acceptability was explored in terms of satisfaction and the appropriateness of the intervention. Changes in perceived physical and mental health at the individual level were examined using a single-subject design, which is consistent with patient-centered care [ 31 ] and allows for the evaluation of subtle changes within individuals over time [ 32 , 33 , 34 ]. Recommendations for intervention refinement were explored qualitatively.…”
Section: Methodsmentioning
confidence: 99%
“…Feasibility was assessed in terms of attendance, drop out, and the challenges related to implementing the pilot, and acceptability was explored in terms of satisfaction and the appropriateness of the intervention. Changes in perceived physical and mental health at the individual level were examined using a single-subject design, which is consistent with patient-centered care [ 31 ] and allows for the evaluation of subtle changes within individuals over time [ 32 , 33 , 34 ]. Recommendations for intervention refinement were explored qualitatively.…”
Section: Methodsmentioning
confidence: 99%