2013
DOI: 10.1002/adma.201303233
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Abstract: Hydrogels are hydrophilic polymer-based materials with high water content and physical characteristics that resemble the native extracellular matrix. Because of their remarkable properties, hydrogel systems are used for a wide range of biomedical applications, such as three-dimensional (3D) matrices for tissue engineering, drug-delivery vehicles, composite biomaterials, and as injectable fillers in minimally invasive surgeries. In addition, the rational design of hydrogels with controlled physical and biologic… Show more

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Cited by 1,130 publications
(880 citation statements)
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“…Stimuli-sensitive hydrogels that generate desirable macroscopic actuation with structural or shape changes upon external stimuli, such as temperature, light, pH, and solvent, can be ideal candidates for artificial soft actuators. [138][139][140] However, these functional hydrogels usually provide simple homogeneous shape changes due to their unordered isotropic structures, which limits their further application. Hence, it is a new direction in the development of artificial soft actuators to design and fabricate stimuli-sensitive hydrogels with alignment structures that possess reversible and anisotropic responsive behavior that is controlled by external stimuli.…”
Section: Soft Actuatorsmentioning
confidence: 99%
“…Stimuli-sensitive hydrogels that generate desirable macroscopic actuation with structural or shape changes upon external stimuli, such as temperature, light, pH, and solvent, can be ideal candidates for artificial soft actuators. [138][139][140] However, these functional hydrogels usually provide simple homogeneous shape changes due to their unordered isotropic structures, which limits their further application. Hence, it is a new direction in the development of artificial soft actuators to design and fabricate stimuli-sensitive hydrogels with alignment structures that possess reversible and anisotropic responsive behavior that is controlled by external stimuli.…”
Section: Soft Actuatorsmentioning
confidence: 99%
“…T ECHNIQUES that could precisely pattern hydrogels with tunable geometric shape and size in micro/nano scale are desired for developing hydrogels' applications in drug delivery [1], cell encapsulation [2], [3], cell-environment interaction research [4], [5] and tissue engineering [6]- [8]. To date, three-dimensional micro hydrogel structures have been created by a variety of methods, including photolithography, softlithography (e.g., micro-contact printing, microfluidic patterning, and micro molding) [9]- [11].…”
Section: Introductionmentioning
confidence: 99%
“…Hydrogels have been widely used to assist the regenerative and reparative processes of many tissues [41,198,199] and several studies were performed assessing their potential as wound healing adjuvant, mainly due to their porosity, permeability, viscoelastic properties and low immunogenicity (depending on the source) [21,39,64,114]. Hydrogels are defined as crosslinked 3D network structures obtained from a range of synthetic or natural polymers that can absorb and retain large amounts of water [7,168]. They are usually classified according to the nature of the crosslinks established between the polymer chains into chemical or physical hydrogels.…”
Section: Hydrogel Bioinksmentioning
confidence: 99%