2016
DOI: 10.1097/bcr.0000000000000201
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Abstract: Critical appraisal of outcomes after burn shock resuscitation with albumin has previously been restricted to small relatively old randomized trials, some with high risk of bias. Extensive recent data from nonrandomized studies assessing the use of albumin can potentially reduce bias and add precision. The objective of this meta-analysis was to determine the effect of burn shock resuscitation with albumin on mortality and morbidity in adult patients. Randomized and nonrandomized controlled clinical studies eval… Show more

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Cited by 73 publications
(10 citation statements)
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“…To the best of our knowledge, this is the first study that demonstrated the significant correlation between serum albumin level and the development of early MODS. Although a recent meta-analysis suggested that albumin supplementation can improve survival during burn shock resuscitation 30 , its clinical benefit in patients with burns remains controversial 31 . However, our findings provided a clear evidence that albumin level upon admission is a convenient marker for evaluating the severity of burn injury and identifying patients who require aggressive management to prevent the development of MODS.…”
Section: Discussionmentioning
confidence: 99%
“…To the best of our knowledge, this is the first study that demonstrated the significant correlation between serum albumin level and the development of early MODS. Although a recent meta-analysis suggested that albumin supplementation can improve survival during burn shock resuscitation 30 , its clinical benefit in patients with burns remains controversial 31 . However, our findings provided a clear evidence that albumin level upon admission is a convenient marker for evaluating the severity of burn injury and identifying patients who require aggressive management to prevent the development of MODS.…”
Section: Discussionmentioning
confidence: 99%
“…The secondary outcomes were in-hospital mortality rate and average hospital length of stay (LOS) for each fiscal year, which could be identified from baseline patient information. These outcomes were estimated as an indicator to evaluate care quality as was done in previous studies [10–12].…”
Section: Methodsmentioning
confidence: 99%
“…Clinical studies evaluating HA efficacy report no clear benefit of HA compared to alternatives, such as crystalloids or non-protein colloids, for initial resuscitation in critically ill patients, such as patients with “bleeding,” “sepsis,” and “burn injury” [4, 10–12]. As such, worldwide clinical guidelines for appropriate use of HA now specify that HA administration is not recommended for initial resuscitation in these critically ill patients, except in special circumstances [13–16].…”
Section: Introductionmentioning
confidence: 99%
“…Though volume resuscitation in burn shock primarily includes crystalloid fluid solutions such as LR, other fluids are often used as resuscitation adjuncts, primarily to "rescue" a patient who is receiving an excessive volume [70]. Of these fluids, albumin and plasma are the most frequently used in clinical practice [71][72][73][74][75][76]. Pruitt et al reported in 1971 that varying doses of colloid provided during the first 24 h postburn had no apparent effect on the rate of plasma volume loss.…”
Section: Adjuncts To Resuscitationmentioning
confidence: 99%