2014
DOI: 10.1056/nejmoa1406617
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Abstract: Among patients with septic shock, mortality at 90 days and rates of ischemic events and use of life support were similar among those assigned to blood transfusion at a higher hemoglobin threshold and those assigned to blood transfusion at a lower threshold; the latter group received fewer transfusions. (Funded by the Danish Strategic Research Council and others; TRISS ClinicalTrials.gov number, NCT01485315.).

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Cited by 709 publications
(610 citation statements)
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“…A large high-quality confirmatory RCT showed no differences by time-and biomarker-independent blood transfusion at haemoglobin values of 7 vs. 9 g/dl on patient-centred outcomes in patients with septic shock [47,48].…”
Section: Blood Transfusion In Patients With Septic Shockmentioning
confidence: 99%
“…A large high-quality confirmatory RCT showed no differences by time-and biomarker-independent blood transfusion at haemoglobin values of 7 vs. 9 g/dl on patient-centred outcomes in patients with septic shock [47,48].…”
Section: Blood Transfusion In Patients With Septic Shockmentioning
confidence: 99%
“…Another recent RCT, the Transfusion Requirements In Septic Shock (TRISS) trial, investigated the impact of liberal versus restrictive transfusion strategies on outcome in 1005 patients with septic shock [7]: 90-day survival rates were similar between groups. Transfusion rates were very high in the liberal arm (98.8 vs. 63.9 % in the restrictive arm).…”
Section: What Is the Evidence?mentioning
confidence: 99%
“…94 In patients with septic shock, no differences in outcome were shown between patients receiving blood transfusion at a threshold of 70 g/l compared to a threshold of 90 g/l. 95 Strikingly, 50 % fewer units of blood were used in the low-threshold group. Importantly, blood transfusions have been associated with an increased morbidity 94,96 and mortality 97,98 after cardiac surgery.…”
Section: Increase Oxygen Transport Capacitymentioning
confidence: 99%