Acquired peanut hypersensitivity following platelet transfusion

Ponnampalam, Arjuna; Growe, Gershon H.; Loftus, Pooja; Chipperfield, Kate; Bigham, Mark

doi:10.1111/tme.12148

Cited by 2 publications

(2 citation statements)

References 10 publications

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“…In another onset pattern, donors possess food allergies, and donor‐derived allergen‐specific IgE is infused into patients during blood transfusion, resulting in a state of passive IgE sensitization 41–43 . Subsequently, when the patient ingests the corresponding food, allergic symptoms develop 37,44,45 . Although analysis of donors or blood products has not been conducted in this study, it is possible that such a mechanism was involved in our study, especially in patients who had food allergies in advance.…”

Section: Discussionmentioning

confidence: 97%

“…[41][42][43] Subsequently, when the patient ingests the corresponding food, allergic symptoms develop. 37,44,45 Although analysis of donors or blood products has not been conducted in this study, it is possible that such a mechanism was involved in our study, especially in patients who had food allergies in advance. This is thought to be important when evaluating especially severe ATR, and analysis of the allergic predisposition of donors in addition to patients is necessary.…”

Section: Discussionmentioning

confidence: 98%

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Relationship between allergic transfusion reactions and allergic predisposition among pediatric patients with hematological/oncological disease

et al. 2022

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Background: Allergic transfusion reactions (ATRs) manifest frequently as transfusion reactions, and their onset may be related to a patient's allergic predisposition. Moreover, although pediatric patients with hematological/oncological disease are more susceptible to ATRs, the relationship between allergic predisposition and ATRs remains to be fully clarified. Study Design and Methods: Patients who were diagnosed with pediatric hematological/oncological disease and received transfusion at the study institutions were included. We determined patient background information related to their allergy history, measured the levels of allergen-specific immunoglobulin E (IgE) using sera obtained on diagnosis, and analyzed their associations with ATR onset.Results: Of the 363 patients analyzed, 144 developed ATRs. Multivariate analysis identified cases with high basophils in the peripheral blood, and Dermatophagoides pteronyssinus-and egg white-specific IgEs were involved in the development of ATR in all age groups. Meanwhile, a history of food allergies, and positivity for Japanese cypress-and D. pteronyssinus-specific IgEs were risk factors for developing ATRs in the <5 years age group. Moreover, patients aged 5-<10 years with a history of asthma, allergic rhinitis, pollinosis, or atopic dermatitis, and those aged ≥10 years with positivity for dog danderspecific IgE were at risk for developing ATRs. Conclusion:The allergic constitution of patients plays a role in ATR onset even in pediatric hematological/oncological diseases. Therefore, advance confirmation of a patient's allergic constitution may partly predict the onset of ATRs. However, since multiple allergic predispositions within complex mechanisms may be involved in the onset of ATRs, further verification is required.

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Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 98%

Relationship between allergic transfusion reactions and allergic predisposition among pediatric patients with hematological/oncological disease

et al. 2022

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Transfusion Reactions

Savage

2016

Hematology/Oncology Clinics of North America

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Transfusion reactions are common occurrences, and clinicians who order or transfuse blood components need to be able to recognize adverse sequelae of transfusion. The differential diagnosis of any untoward clinical event should always consider adverse sequelae of transfusion, even when transfusion occurred weeks earlier. There is no pathognomonic sign or symptom that differentiates a transfusion reaction from other potential medical problems, so vigilance is required during and after transfusion when a patient presents with a change in clinical status. This review covers the presentation, mechanisms, and management of transfusion reactions that are commonly encountered, and those that can be life-threatening.

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Acquired peanut hypersensitivity following platelet transfusion

Cited by 2 publications

References 10 publications

Relationship between allergic transfusion reactions and allergic predisposition among pediatric patients with hematological/oncological disease

Relationship between allergic transfusion reactions and allergic predisposition among pediatric patients with hematological/oncological disease

Transfusion Reactions

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