2014
DOI: 10.7326/m14-0178
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Abstract: The Hamilton Chapter of the Canadian Intensive Care Foundation and the Critical Care Medicine Residency Program and Critical Care Division Alternate Funding Plan at McMaster University.

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Cited by 232 publications
(107 citation statements)
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“…32 Studies involving healthy volunteers suggest saline may decrease renal perfusion through chloride-mediated renal vaso-constriction. 33 Observational studies involving critically ill adults have shown higher rates of acute kidney injury, 34 renal-replacement therapy, 5,10 and death 6,7,9,35 with saline than with balanced crystalloids, although results have been inconsistent. 36 Although underpowered for clinical outcomes, two recent pilot trials involving critically ill adults showed an absolute difference of 1 percentage point in mortality in favor of balanced crystalloids.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…32 Studies involving healthy volunteers suggest saline may decrease renal perfusion through chloride-mediated renal vaso-constriction. 33 Observational studies involving critically ill adults have shown higher rates of acute kidney injury, 34 renal-replacement therapy, 5,10 and death 6,7,9,35 with saline than with balanced crystalloids, although results have been inconsistent. 36 Although underpowered for clinical outcomes, two recent pilot trials involving critically ill adults showed an absolute difference of 1 percentage point in mortality in favor of balanced crystalloids.…”
Section: Discussionmentioning
confidence: 99%
“…2,3 Data suggest that intravenous saline may be associated with hyperchloremic metabolic acidosis, 4 acute kidney injury, 5 and death. 6,7 Crystalloid solutions with electrolyte compositions closer to that of plasma (balanced crystalloids, such as lactated Ringer’s solution or Plasma-Lyte A) represent an increasingly used alternative to saline. 8 Several observational studies 6,9,10 and a before-and-after trial 5 suggested that the use of balanced crystalloids is associated with lower rates of acute kidney injury, renal-replacement therapy, and death.…”
mentioning
confidence: 99%
“…И если на 28-е сутки заболевания не было выявлено достоверной меж-групповой разницы в летальности, то выживаемость больных на фоне альбумина достоверно улучшалась: 90-дневная смертность достигала 43,6 % в группе альбумина против 49,9 % в группе кристаллоидов. Метаанализ [19], включавший 14 исследований, 18 916 больных с сепсисом, показал, что жидкостная ресусцитация сбалансированными кристаллоидами или ЧСА снижает летальность при сепсисе. Это же было подтверждено в ряде других метаанализов [20,21].…”
Section: использование в клиникеunclassified
“…An observational study of adults with septic shock associated higher chloride and increased mortality 31 , with a dose-response curve for chloride that appears independent of volume of fluid received 32 . A recent meta-analysis linked balanced crystalloids to reduced mortality in sepsis 33 , although another suggested no relationship between chloride content and renal replacement therapy 34 . Ongoing randomized trials (ACTRN12613001370796, NCT02444988) comparing saline to balanced crystalloids in critically ill populations may definitively establish the impact of crystalloid choice on AKI and mortality among patients with sepsis.…”
Section: Fluid Choicementioning
confidence: 99%