Prevalence of Obesity in the United States

Rimm, Alfred A.

doi:10.1001/jama.2014.6219

Cited by 19 publications

(2 citation statements)

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“…With more than 1.4 billion overweight or obese adults (Hall et al, 2015), obesity has become a major threat to public health in both developed and developing countries (Haslam and James, 2005). In the United States, more than 36% of adults are obese with a body mass index (BMI) greater than 30 kg/m 2 (Ogden et al, 2014). The mean BMI in Chinese adults also increased from 22.7 kg/m 2 in 2004 to 23.7 kg/m 2 in 2010 with the prevalence of obesity increased from 3.3% in 2004 to 5.2% in 2010 (Jiang Y. et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

Bacillus amyloliquefaciens SC06 Protects Mice Against High-Fat Diet-Induced Obesity and Liver Injury via Regulating Host Metabolism and Gut Microbiota

Wang

et al. 2019

Front. Microbiol.

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Obesity and the related liver diseases are prevalent around the world. Although probiotics have been shown to prevent obesity through multiple ways, only few researches investigated the lipid-lowering effects of probiotic Bacillus . Moreover, the limited results consistently suggested that Bacillus regulated genes related to lipogenesis and oxidation, but no further exploration was made. Our previous study revealed that Bacillus amyloliquefaciens SC06 has a potent antioxidant capacity in vitro . The aim of this study is to investigate the effects of SC06 on obesity and the associated liver injury of high-fat diet (HFD)-fed-mice and its underlying mechanism. By feeding normal chow (NC), NC+SC06, HFD, and HFD+SC06 to mice, we found that SC06 improved body weight gain, hepatic steatosis, and glucose metabolism of HFD-mice. Furthermore, SC06 also increased the antioxidant capacity of mice through Nrf2/Keap1 signaling pathway. High-throughput sequencing of 16S rRNA gene showed that HFD changed the gut microbiota dramatically, while HFD+SC06 decreased the ratio of Firmicutes/Bacteroidetes and increased TM7 abundance. More differences were also found in lower taxa. Altogether, SC06 is a potential probiotic that decreases HFD-related lipid accumulation and liver injury via regulating the antioxidant capacity and host gut microbiota.

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Section: Introductionmentioning

confidence: 99%

Bacillus amyloliquefaciens SC06 Protects Mice Against High-Fat Diet-Induced Obesity and Liver Injury via Regulating Host Metabolism and Gut Microbiota

Wang

et al. 2019

Front. Microbiol.

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show abstract

“…Further, in the elderly and obese populations (one-third of the population in the U.S. is classified as obese) robotic approach may have some benefits. 8 …”

Section: Introductionmentioning

confidence: 99%