Perceived stress during pregnancy and the catechol-O-methyltransferase (COMT) rs165599 polymorphism impacts on childhood IQ

Lamb, Yvette N.; Thompson, John M. D.; Murphy, Rinki; Wall, Clare; Kirk, Ian J.; Morgan, Angharad R.; Ferguson, Lynnette R.; Mitchell, Edwin A.; Waldie, Karen E.

doi:10.1016/j.cognition.2014.05.009

Cited by 15 publications

(12 citation statements)

References 62 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The results of a study by Entringer et al [18] showed that women who report a negative effect of pregnancy on jobs also undergo more stress during pregnancy [19]. In a prospective longitudinal study, children who are exposed to pregnancy stress received lower scores on IQ tests at the ages of 7 and 11, compared to the control group [20].…”

Section: Introductionmentioning

confidence: 98%

The Role of Perceived Stress and Social Support among Predicting Anxiety in Pregnant Women

Basharpoor

Heydarirad

Daryadel

et al. 2017

J Holist Nurs Midwifery

View full text Add to dashboard Cite

Introduction: Pregnancy anxiety is a common disorder occurred due to various factors. It has significant impact on the outcome of pregnancy. Objective: This study aimed at determining the role of perceived stress and social support to tame anxiety among pregnant women. Materials and Methods: This is a descriptive-analytical study with correlational design. The study's population included all pregnant women who were referred to Ardabil health centers in the second half of 2013 to receive prenatal care. A total of 110 subjects were selected using random sampling method and responded to demographic, perceived stress and social support questionnaires. The data collected was analyzed using Pearson's correlation coefficient and multiple regression analysis. Results: The results showed that anxiety during pregnancy had a negative correlation with negative perception of stress (r=0.56; P<0.001) and positive correlation with positive perception of stress (r=-0.36; P<0.001). It also has support of friends (r=0.42; P<0.001) and family (r=-0.52; P<0.001) and total score of social protection (r=0.52; P<0.001). Results of regression analysis also revealed that 37% of the total variance of pregnancy anxiety is justified by perceived stress and social support. Conclusion: The results showed that the perception of stress and social support received by pregnant women play a role in anxiety during pregnancy.

show abstract

Section: Introductionmentioning

confidence: 98%

The Role of Perceived Stress and Social Support among Predicting Anxiety in Pregnant Women

Basharpoor

Heydarirad

Daryadel

et al. 2017

J Holist Nurs Midwifery

View full text Add to dashboard Cite

show abstract

“…Developmental exposures to lead (Pb) and to prenatal stress (PS) remain significant risk factors for subsequent adverse behavioral outcomes in children (Bock et al 2015;Canfield et al 2003Canfield et al , 2004Jusko et al 2008;Nigg et al 2008;Pallarés and Antonelli 2017), including cognitive dysfunction, reduced IQ, and attention deficits (Canfield et al 2004;Geier et al 2018;Gutteling et al 2006;Ji et al 2018;Lamb et al 2014;Lanphear et al 2005;Zhu et al 2015). These consequences can even persist across the life span (Needleman et al 1990;Schwabe et al 2012).…”

Section: Introductionmentioning

confidence: 99%

Lineage- and Sex-Dependent Behavioral and Biochemical Transgenerational Consequences of Developmental Exposure to Lead, Prenatal Stress, and Combined Lead and Prenatal Stress in Mice

Sobolewski

Abston

Conrad

et al. 2020

Environ Health Perspect

View full text Add to dashboard Cite

BACKGROUND: Lead (Pb) exposure and prenatal stress (PS) during development are co-occurring risk factors with shared biological substrates. PS has been associated with transgenerational passage of altered behavioral phenotypes, whereas the transgenerational behavioral or biochemical consequences of Pb exposure, and modification of any such effects by PS, is unknown. OBJECTIVES: The present study sought to determine whether Pb, PS, or combined Pb and PS exposures produced adverse transgenerational consequences on brain and behavior. METHODS: Maternal Pb and PS exposures were carried out in F0 mice. Outside breeders were used at each subsequent breeding, producing four F1-F2 lineages: [F1 female-F2 female (FF), FM (male), MF, and MM]. F3 offspring were generated from each of these lineages and examined for outcomes previously found to be altered by Pb, PS, or combined Pb and PS in F1 offspring: behavioral performance [fixed-interval (FI) schedule of food reward, locomotor activity, and anxiety-like behavior], dopamine function [striatal expression of tyrosine hydroxylase (Th)], glucocorticoid receptor (GR) and plasma corticosterone, as well as brain-derived neurotrophic factor (BDNF) and total percent DNA methylation of Th and Bdnf genes in the frontal cortex and hippocampus. RESULTS: Maternal F0 Pb exposure produced runting in F3 offspring. Considered across lineages, F3 females exhibited Pb-related alterations in behavior, striatal BDNF levels, frontal cortical Th total percentage DNA methylation levels and serum corticosterone levels, whereas F3 males showed Pb-and PS-related alterations in behavior and total percent DNA methylation of hippocampal Bdnf. However, numerous lineage-specific effects were observed, most of greater magnitude than those observed across lineages, with outcomes differing by F3 sex. DISCUSSION: These findings support the possibility that exposures of previous generations to Pb or PS may influence the brain and behavior of future generations. Observed changes were sex-dependent, with F3 females showing multiple changes through Pb-exposed lineages. Lineage effects may occur through maternal responses to pregnancy, altered maternal behavior, epigenetic modifications, or a combination of mechanisms, but they have significant public health ramifications regardless of mechanism. https://doi.

show abstract

“…A growing body of research has revealed an association between antenatal maternal stress and impaired cognitive development from infancy to adolescence (Huizink et al ., ; Lamb et al ., ; Laplante et al ., , ; Li et al ., ; Niederhofer & Reiter, ). In addition, genetic studies suggest cognitive abilities such as reading possess a strong genetic component (Cope et al ., ; Francks et al ., ; Lind et al ., ; Meng et al ., ; Paracchini et al ., , 2011; Scerri et al ., ).…”

Section: Discussionmentioning

confidence: 99%

“…The resulting composite scores range from 0 to 40, with higher scores signalling greater perceived stress. A median split of the data was used to categorize higher and lower stress scores (Lamb et al ., ).…”

Section: Methodsmentioning

confidence: 97%

“…Further cognitive deficits associated with stress during pregnancy include delayed development in memory, learning, and problem‐solving skills (Huizink, Robles de Medina, Mulder, Visser, & Buitelaar, ), lower intelligence quotient (IQ) (Lamb et al ., ), poorer academic performance in literacy and numeracy (Li et al ., ; Niederhofer & Reiter, ), and impaired cognitive regulation (Van den Bergh, Mennes, et al ., ). A potential mechanism governing these outcomes is foetal programming (Van den Bergh, Mulder, Mennes, & Glover, ).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Associations Between the KIAA0319 Dyslexia Susceptibility Gene Variants, Antenatal Maternal Stress, and Reading Ability in a Longitudinal Birth Cohort

et al. 2016

Self Cite

View full text Add to dashboard Cite

Maternal stress during pregnancy has been associated with detrimental cognitive developmental outcomes in offspring. This study investigated whether antenatal maternal perceived stress and variants of the rs12193738 and rs2179515 polymorphisms on the KIAA0319 gene interact to affect reading ability and full-scale IQ (FSIQ) in members of the longitudinal Auckland Birthweight Collaborative study. Antenatal maternal stress was measured at birth, and reading ability was assessed at ages 7 and 16. Reading data were available for 500 participants at age 7 and 479 participants at age 16. FSIQ was measured at ages 7 and 11. At age 11, DNA samples were collected. Analyses of covariance revealed that individuals with the TT genotype of the rs12193738 polymorphism exposed to high maternal stress during pregnancy possessed significantly poorer reading ability (as measured by Woodcock-Johnson Word Identification standard scores) during adolescence compared with TT carriers exposed to low maternal stress. TT carriers of the rs12193738 SNP also obtained lower IQ scores at age 7 than C allele carriers. These findings suggest that the KIAA0319 gene is associated with both reading ability and general cognition, but in different ways. The effect on IQ appears to occur earlier in development and is transient, whereas the effect of reading ability occurs later and is moderated by antenatal maternal stress. Copyright © 2016 John Wiley & Sons, Ltd.

show abstract

Perceived stress during pregnancy and the catechol-O-methyltransferase (COMT) rs165599 polymorphism impacts on childhood IQ

Cited by 15 publications

References 62 publications

The Role of Perceived Stress and Social Support among Predicting Anxiety in Pregnant Women

The Role of Perceived Stress and Social Support among Predicting Anxiety in Pregnant Women

Lineage- and Sex-Dependent Behavioral and Biochemical Transgenerational Consequences of Developmental Exposure to Lead, Prenatal Stress, and Combined Lead and Prenatal Stress in Mice

Associations Between the KIAA0319 Dyslexia Susceptibility Gene Variants, Antenatal Maternal Stress, and Reading Ability in a Longitudinal Birth Cohort

Contact Info

Product

Resources

About