Ultrasound backscatter measurements of intact human proximal femurs—Relationships of ultrasound parameters with tissue structure and mineral density

Malo, Markus; Töyräs, Juha; Karjalainen, Janne; Isaksson, Hanna; Riekkinen, Ossi; Jurvelin, Jukka S.

doi:10.1016/j.bone.2014.04.014

Cited by 30 publications

(29 citation statements)

References 35 publications

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“…Such development could be of particular interest in the context of spine surgery because (i) pins are used and (ii) bone quality is of interest for the surgical protocol (particularly with respect to the insertion of pedicle screws and the prediction of the biomechanical stability of disc prostheses). Note that some methods have been developed using the backscattering echographic response of bone microstructure (Hoffmeister et al 2012;Jiang et al 2014;Malo et al 2014), but are difficult to use in vivo. The present approach is different because it uses a substitution method through the echo of the pin.…”

Section: Discussionmentioning

confidence: 99%

Ultrasound Speed of Sound Measurements in Trabecular Bone Using the Echographic Response of a Metallic Pin

Guipieri

Nagatani

Bosc

et al. 2015

Ultrasound in Medicine & Biology

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Section: Discussionmentioning

confidence: 99%

Ultrasound Speed of Sound Measurements in Trabecular Bone Using the Echographic Response of a Metallic Pin

Guipieri

Nagatani

Bosc

et al. 2015

Ultrasound in Medicine & Biology

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“…However, the results of the present study for nMBD demonstrate good agreement with results from previous studies that used different measurement systems. 12,16 …”

Section: Discussionmentioning

confidence: 99%

Backscatter-difference Measurements of Cancellous Bone Using an Ultrasonic Imaging System

et al. 2015

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Backscatter difference measurements may be used to detect changes in bone caused by osteoporosis. The backscatter difference technique measures the power difference between two portions of an ultrasonic backscatter signal. The goal of this study is to evaluate the feasibility of using an ultrasonic imaging system to perform backscatter difference measurements of bone. Ultrasonic images and backscatter signals were acquired from 24 specimens of human cancellous bone. The signals were analyzed in the frequency domain to determine the normalized mean backscatter difference (nMBD) and in the time domain to determine the normalized backscatter amplitude ratio (nBAR). The images were analyzed to determine the normalized pixel value difference (nPVD), which measures the difference in average pixel brightness between regions of interest placed at two different depths in the image. All three parameters were found to increase with bone mineral density. The signal-based parameters, nMBD and nBAR, correlated well with bone mineral density, yielding linear correlation coefficients that ranged from 0.74 to 0.87. The image based parameter, nPVD, performed somewhat less well, yielding correlation coefficients that ranged from 0.42 to 0.81. These results suggest that ultrasonic imaging systems may be used to perform backscatter difference measurements for the purpose of ultrasonic bone assessment.

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“…[10][11][12] In addition, when extracting backscatter parameters in pulse-echo (PE) measurements of trabecular bone, cortical thickness should be measured to compensate for ultrasound attenuation. [12][13][14] PE ultrasound techniques are included in the suite of compact, cheap, and nonionizing solutions to quantify fracture risk. The techniques hold much potential especially for screening at primary healthcare facilities.…”

Section: Introductionmentioning

confidence: 99%

Effect of porosity, tissue density, and mechanical properties on radial sound speed in human cortical bone

Eneh

Malo

Karjalainen³

et al. 2016

Med. Phys.

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Use of a predefined, constant value for radial SOS in cortical bone, i.e., neglecting the effect of measured variation in cortical porosity, propagated to an error of 6% in cortical thickness. This error can be critical as characteristic cortical thinning of 1.10% ± 1.06% per yr decreases bending strength of the distal radius and results in increased fragility in postmenopausal women. Provided that the cortical porosity can be estimated in vivo, the relationship between radial SOS and cortical porosity can be utilized and a porosity based radial SOS estimate could be implemented to determine cortical thickness. This would constitute a step toward individualized quantitative ultrasound diagnostics of osteoporosis.

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Ultrasound backscatter measurements of intact human proximal femurs—Relationships of ultrasound parameters with tissue structure and mineral density

Cited by 30 publications

References 35 publications

Ultrasound Speed of Sound Measurements in Trabecular Bone Using the Echographic Response of a Metallic Pin

Ultrasound Speed of Sound Measurements in Trabecular Bone Using the Echographic Response of a Metallic Pin

Backscatter-difference Measurements of Cancellous Bone Using an Ultrasonic Imaging System

Effect of porosity, tissue density, and mechanical properties on radial sound speed in human cortical bone

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